ID U1QMD3_9ACTO Unreviewed; 1125 AA.
AC U1QMD3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE Flags: Fragment;
GN ORFNames=HMPREF1979_02106 {ECO:0000313|EMBL:ERH22894.1};
OS Actinomyces johnsonii F0542.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=1321818 {ECO:0000313|EMBL:ERH22894.1, ECO:0000313|Proteomes:UP000016536};
RN [1] {ECO:0000313|EMBL:ERH22894.1, ECO:0000313|Proteomes:UP000016536}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0542 {ECO:0000313|EMBL:ERH22894.1,
RC ECO:0000313|Proteomes:UP000016536};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERH22894.1}.
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DR EMBL; AWSE01000120; ERH22894.1; -; Genomic_DNA.
DR RefSeq; WP_021608696.1; NZ_KE951902.1.
DR AlphaFoldDB; U1QMD3; -.
DR PATRIC; fig|1321818.3.peg.1771; -.
DR HOGENOM; CLU_279735_0_0_11; -.
DR Proteomes; UP000016536; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 265..602
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 420..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1065
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ERH22894.1"
SQ SEQUENCE 1125 AA; 119617 MW; 4A4050A869FBB221 CRC64;
GRAAHLLREG HGDGVVRVRT PAALALTILT TSLTRRPDPL PPPVLLAGAE EDSVLASMIS
AISWPGLPAE ATGSRAFRSE LRNLLARAGE LGITADELAD LGRRLDVPIW GPAAQLLRTW
DAQGRPSADR RAQTRKMDTA RLQDRAVESL RTWGSDGVTA PRPVPDLVIV DDYQDCTAAT
ARLLTALATP DPDGHRAQIV VVGDPDVAVE TFRGGTPSLL IAAEDNSGLG ATRLRLSTCY
RGDPVIAMAV ADQSARVPVT GTAAHRRTTL APRTPVSRIL QAPDEDRAAA PAGVEAILAS
ISWQERAHVA RVLRLEHVHH GTPWSQMAVI VRSANEAEAL ARDLRRRGVP LASRTPAVLL
RAEPAAAALL DIVRAGLRDQ LGDGGEPPQR EAAINLLTSP LVGLTTMDLR RLRRRLRQDH
DAAQLATSTG EAEASGGTDT RAGADAALLA LLTDADRAGA LARSLEGESL GIQAGRLLTA
SRIIEALRTA MRDTVTDAPR DVEALLWAAW DASGRAEAWR ATALRPSGDS ARSVLSEAAE
HDLDVVTTLF KRAEVWAERH PGQDASGFLA ELDAEVLPSD SVAPQGRRPE GVAVMTPARC
AGQEWEFVVV TGLERDRWPD LRLRDSLTRT GLLVDAVTDR LPVGVDVAGT ADDNGDDGAI
AAARAQVRAD ERRMLIMALS RASRRLLLTA TADAEHAPSP FLMEIARATG IQLADDDGAP
IVTPDTGDLT LRGLVGELRR AAVVGSLETA APAERRLGRA AAAMLAELAD QNVPGADPAT
WIGAGGPTST TPLITEGQRI RVSPSDVEGL SACPLKWFLS RNGGSAPAGD AQTLGSLVHA
VAEKAEREHL RGPALQELFE ERLGDLGYAD TWQGGLAADR ARAMIERLDA YLRDCDALGI
RADVEQPVRA HLDIPLEVLS PEVRSRVEER VPASGPRILP VTISGRIDRL EHIGEAPQDG
PDGDEEDDVV RVMDLKTGRR VPRAAHRHPQ LAAYQLALSS QGLDVIGGAL VLLGKEPTRR
SADGYVLAPV GAALDPNPYV LRLPSDDLDT DLVDPELEDE SGGGAADDAE APAKFRQDYW
TEDLVASAAV AGMGPLIEAR TGEQCRTCMV KDSCPVQVEG RRVVS
//
