ID U1QZX8_9EURY Unreviewed; 899 AA.
AC U1QZX8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
DE Flags: Fragment;
GN ORFNames=J07HB67_00605 {ECO:0000313|EMBL:ERH11597.1};
OS halophilic archaeon J07HB67.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales.
OX NCBI_TaxID=1085029 {ECO:0000313|EMBL:ERH11597.1};
RN [1] {ECO:0000313|EMBL:ERH11597.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23637883;
RA Podell S., Ugalde J.A., Narasingarao P., Banfield J.F., Heidelberg K.B.,
RA Allen E.E.;
RT "Assembly-driven community genomics of a hypersaline microbial ecosystem.";
RL PLoS ONE 8:E61692-E61692(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE356582; ERH11597.1; -; Genomic_DNA.
DR AlphaFoldDB; U1QZX8; -.
DR STRING; 1085029.J07HB67_00605; -.
DR HOGENOM; CLU_322003_0_0_2; -.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000313|EMBL:ERH11597.1};
KW Hydrolase {ECO:0000313|EMBL:ERH11597.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nuclease {ECO:0000313|EMBL:ERH11597.1};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 119..190
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 343..479
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
FT REGION 826..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ERH11597.1"
SQ SEQUENCE 899 AA; 101680 MW; 50BF836F039C0FCA CRC64;
TDVDRQDVYL SDEALEDAIT SVIGDYNFTV TEQTAYDIDI DVDPTMLGKI YESLIARANR
GDSGIFYTGR QEVDLICRKA VLEQLRRRAD DADPGGEELI EFVFRDPESG ASEELQETVE
PWLDELSIVD PACGSGAFLT GLFQVLTELY EKLGVQLSYE DRLQIINNSI YGVDIKDWAV
RVAEFRLWLG LIEPETNVPS QTPVLPNFSF NVQSGDSLIQ QVGDQRLSVQ ALERSPSDEV
QRELREVEDL KRRYFDGAFE LESEIERRQT ELLRAHISGL IDRLDSGEQQ TLGGGVTQSS
EDRRKELAIE RLESVRDNLD ASGSERSFIW ELNFSEVMLN GGFDAVVGNP PYVSTEFITD
PWYSQDQLDE MSSARVSEIQ DQYKSQLSEY VREYHGLDPD GQSDYYAFFF YKGMELLREG
GTLSYISSDK WLDRDYGTDL QRHFLKETRL ESIIANRNKR SFEQAEITTA ITTLTRDSSN
REDAAPRFVS CHRPYESIYT PETVSELFYG GSFDSAAYKS EEIGVLDSSV AKVVRVDTPV
LWKLGGGSVS ERGSGGRPRL GGTYSGAVWG SVYLRTPTPV FEILDRTNGD DVRRLREFDI
QSYLNARGAK GFFVVEEVEV LEDSSIRIEN TDHGEQFEIE GQFLEPFVGS PSNVESVRID
EDDTDDERIV VVPEDTDTDS YDVGNYIEFG ESVDYDMASG NSSKDTWYQP PARAEEAAPI
VLPRTHNTNH RAFYNPDEIV TGRFYRARFE DESPEEVEFA SLVLNSTLGS LFMEIYGDTR
GQGALDLYTD DYERLPVVLP DSVNTTELDD RAYELLDRSP GTVFEELGVE RPDESDSGDT
NSEGIDSEDI DFESIEADRR ALDQFVMETV FELTEEEQRE VYAGLLKLVD ERLNKANSV
//
