ID U1R8X3_9ACTO Unreviewed; 856 AA.
AC U1R8X3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=ATP-dependent helicase HrpB {ECO:0000313|EMBL:ERH14957.1};
GN ORFNames=HMPREF1978_01340 {ECO:0000313|EMBL:ERH14957.1};
OS Actinomyces graevenitzii F0530.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=1321817 {ECO:0000313|EMBL:ERH14957.1, ECO:0000313|Proteomes:UP000016481};
RN [1] {ECO:0000313|EMBL:ERH14957.1, ECO:0000313|Proteomes:UP000016481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0530 {ECO:0000313|EMBL:ERH14957.1,
RC ECO:0000313|Proteomes:UP000016481};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERH14957.1}.
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DR EMBL; AWSC01000057; ERH14957.1; -; Genomic_DNA.
DR RefSeq; WP_021603485.1; NZ_KE951488.1.
DR AlphaFoldDB; U1R8X3; -.
DR PATRIC; fig|1321817.3.peg.1176; -.
DR HOGENOM; CLU_001832_5_6_11; -.
DR Proteomes; UP000016481; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17990; DEXHc_HrpB; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010225; HrpB.
DR InterPro; IPR049614; HrpB_DEXH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013689; RNA_helicase_ATP-dep_HrpB_C.
DR NCBIfam; TIGR01970; DEAH_box_HrpB; 1.
DR PANTHER; PTHR43519; ATP-DEPENDENT RNA HELICASE HRPB; 1.
DR PANTHER; PTHR43519:SF1; ATP-DEPENDENT RNA HELICASE HRPB; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF08482; HrpB_C; 1.
DR PIRSF; PIRSF005496; ATP_hel_hrpB; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ERH14957.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 22..187
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 227..394
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 834..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 92293 MW; B25BFF53CAE9A9CD CRC64;
MLEQLIAAPP PLPVAESLEA LTALATPGNC ALITAPAGSG KTTLLSPAIA VALGGLENRR
VLVTQPRRVA VRAAARRIAS LLGQEVGQEV GYSVRGDRRV SEATRIEMLT PGVLLRRIQN
DPELPGVGAV VLDEFHERDL DTDLALAFCL DVRASLREDL FLAITSATLD ANPVAGLLNK
ATDSTCITTE IPTPIHPLDI VYKPTSQAAL TPNSQGRMGV NPKFLAHCSQ VVAAEASQTN
DDILVFLPGV GEIERVRQLL SPQVGDDVEI LSLHGQLSGP EQDRIFSPSA KQRIILATAI
AESSLTVPRV RTVVDAALAR EPRLDVRRGI GQLVTLPASR ARLAQRAGRA ARLGPGRAIR
LMDKVDYARR PAHSQPQIAT SQLTNMRLQA AVWGAKNPTD LYLLDPPPSG AWSQAGQQLR
ALGAINDDGA ATKVGRKLAK LPLEPALARA LWQGSALMGI RDAAQCVATL AQDLRVSDTD
LARLANKILF QGAPQGSNAY QSSEAGQIRR EAKRLEAIAK TEFGNQAPEK ILEKRSFQDC
LALISALAYP QLLACKRPDS DTYLLANGVG AQLESHSPLI GQQWLAVSGI DRAPTSRQAR
ILAAVPISED EALAAGQALV NERDQIIIEN GQVSGIKQQR LGQIVLRTSA TNPSPEQALE
AVKQYLYKQG LQVLNWSKEA INLRQRMGAL HLGLGSPWPD VSDQALLASQ DSWLAPYAQL
LTHRSISQIS MLEVMQSMLP WPQAAQLDEL APVNMLIPSG ISKAIDWSSG RPVLTLRVQQ
AFGWTSSPRL IGGEVALLLH LTDPAGRQVA ITDDLASFWA GPYQQVRSQL RGRYTKHPWP
QDPLNATPTN RAKPRK
//
