ID U1SDP7_9BIFI Unreviewed; 914 AA.
AC U1SDP7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=FtsK/SpoIIIE family protein {ECO:0000313|EMBL:ERH30068.1};
GN ORFNames=HMPREF9244_01357 {ECO:0000313|EMBL:ERH30068.1};
OS Alloscardovia omnicolens F0580.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Alloscardovia.
OX NCBI_TaxID=1321816 {ECO:0000313|EMBL:ERH30068.1, ECO:0000313|Proteomes:UP000016519};
RN [1] {ECO:0000313|EMBL:ERH30068.1, ECO:0000313|Proteomes:UP000016519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0580 {ECO:0000313|EMBL:ERH30068.1,
RC ECO:0000313|Proteomes:UP000016519};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination.
CC {ECO:0000256|ARBA:ARBA00024986}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERH30068.1}.
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DR EMBL; AWSI01000037; ERH30068.1; -; Genomic_DNA.
DR RefSeq; WP_021618476.1; NZ_KE952645.1.
DR AlphaFoldDB; U1SDP7; -.
DR STRING; 419015.HMPREF3214_01340; -.
DR PATRIC; fig|1321816.3.peg.1197; -.
DR HOGENOM; CLU_001981_2_2_11; -.
DR Proteomes; UP000016519; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000016519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 525..725
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 263..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 542..549
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 914 AA; 98698 MW; 81894F829342290F CRC64;
MKVLLFIPRV FAQLIRDIFG SSSENSDSRL DASCFLLIIF SVLLIASEWF RVDGVLGRYL
HILAAGAFGI MSVILPIVFL FIAFRLIRNS NLEAENTRVL SGWFLLVWSI SSVLDVLMVA
GEPHFSWSAL RSAGGLFGHV LGTPLALGLS KPFAVVIFVF IAAFALLMIT GLHIAEIPRL
LGMTTADNSA SDDDQFPEDV RVGDETLAFA QGVPAHDGTD EAEQSVRQPW WKKLFNRMRH
EETDTNLDEY EGDTAFQNPM RVQDDSQTNR QNVRSAQSGR FEPDFGEDET RAIGREAGAN
APEFSGAAQA AAGRIAGHVP ATSSPQDIAE TMAVAGAGAV GAVAGEVGST RAVPTHSSAV
APEQSPSQED NESQSGGFEQ LPAPSDNGQT YQKPSLDLLV AGKPHAVRTE ANERVIHALR
ATFQEFGVDA DVVGFLRGPS VTQYEVELGP GVKVEKVTNL QRNIAYAVAS SDVRILSPIP
GKSAIGIEIP NIDREIVHLG DVLRSPEALN DNNPMTVGLG KDVEGNFVTA NLTAMPHLLV
AGATGSGKSS FINSMLTSIV MRATPEQVRL IMVDPKRVEL TAYAGIPHLL TPIITDPKRA
AQALEWVVKE MDARYDDLQY FGFRHVKDFN EAVLAGKVHA PAGSNRKVAP YPYLLVVVDE
MADLMMVAKN DVESSIQRIT QLARAAGIHL VLATQRPSVD VVTGLIKSNV PSRLAFATSS
ATDSRVILDS VGAEALIGQG DALFLPMGKP KPTRVQGAWV SESEIRSAVD FVKTQRKPQY
RQDIEQMAAQ QDTKQAIDEE IGNDMDDLLQ AAELVVGAQF GSTSMLQRKL RIGFAKAGRL
MDLLESRGVV GPSEGSKARE VLVQPSQLQE VLGFIRGDAP SIDAAAQAQV EEHHNENSSY
PSDYDGADTY DNEG
//
