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Database: UniProt
Entry: U1SIJ5_9BIFI
LinkDB: U1SIJ5_9BIFI
Original site: U1SIJ5_9BIFI 
ID   U1SIJ5_9BIFI            Unreviewed;       526 AA.
AC   U1SIJ5;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   25-OCT-2017, entry version 32.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF9244_00205 {ECO:0000313|EMBL:ERH31768.1};
OS   Alloscardovia omnicolens F0580.
OC   Bacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae;
OC   Alloscardovia.
OX   NCBI_TaxID=1321816 {ECO:0000313|EMBL:ERH31768.1, ECO:0000313|Proteomes:UP000016519};
RN   [1] {ECO:0000313|EMBL:ERH31768.1, ECO:0000313|Proteomes:UP000016519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0580 {ECO:0000313|EMBL:ERH31768.1,
RC   ECO:0000313|Proteomes:UP000016519};
RA   Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R.,
RA   Fronick C., O'Laughlin M., Godfrey J., Miner T., Herter B.,
RA   Appelbaum E., Cordes M., Lek S., Wollam A., Pepin K.H., Palsikar V.B.,
RA   Mitreva M., Wilson R.K.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ERH31768.1}.
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DR   EMBL; AWSI01000009; ERH31768.1; -; Genomic_DNA.
DR   RefSeq; WP_021617358.1; NZ_KE952640.1.
DR   EnsemblBacteria; ERH31768; ERH31768; HMPREF9244_00205.
DR   PATRIC; fig|1321816.3.peg.170; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000016519; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016519};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016519}.
FT   DOMAIN      212    349       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      428    497       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     220    227       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   526 AA;  57829 MW;  85862D3A7487CB57 CRC64;
     MADMMDAAEV WNQSYQLLLD QPLELTLREM ACLSDIHATN IFGTMIVLTV SSESTRTVVE
     KKLHKALTSI FSQVTGQPMT YVVQIDPHIL EQNEATPASP AAHTSPVNNT VTAPPVTKPV
     TPSAAPERTA PVHHEQVSQH SSVPTPVADE SPVPAAVQPD IVSSAMMDTP ANTRDAVTHL
     NKNAIFDNFV PGESNQFAKS IAFATAERPG MEYNPLFIYG GSGLGKTHLL NAIGNQALLI
     NPNLKVRYTN SEEFTNELVI ALGNNASSRR AEMVEFNRRY RGVDILLVDD VQFIAGRDTT
     VEAFFNTFNE LYEQGKQIVL ASDVPPKNLK GLPDRLISRF SQGLPVSIDP PSHELRVAIL
     RMKAKAQHID IPMDVLNLIA EKVTENVRVL EGALTRISAM ASLSNQTITK SLAEQTLKDF
     TNSTVEITPT NIISFVAQYY KLTFEDIVGS SRTKNVAAAR QMAMYLSREL TSMSLVDIGA
     TFGGRDHSTV MHACRKISSE MQEQQETYTA VTKLTNQLKQ NRTFAE
//
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