ID U2BS34_CLOSY Unreviewed; 332 AA.
AC U2BS34;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=prolyl aminopeptidase {ECO:0000256|ARBA:ARBA00012568};
DE EC=3.4.11.5 {ECO:0000256|ARBA:ARBA00012568};
DE AltName: Full=Prolyl aminopeptidase {ECO:0000256|ARBA:ARBA00029605};
GN ORFNames=CLOSYM_03471 {ECO:0000313|EMBL:ERI75035.1};
OS [Clostridium] symbiosum ATCC 14940.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=411472 {ECO:0000313|EMBL:ERI75035.1, ECO:0000313|Proteomes:UP000016491};
RN [1] {ECO:0000313|EMBL:ERI75035.1, ECO:0000313|Proteomes:UP000016491}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14940 {ECO:0000313|EMBL:ERI75035.1,
RC ECO:0000313|Proteomes:UP000016491};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of N-terminal proline from a peptide.; EC=3.4.11.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001585};
CC -!- SIMILARITY: Belongs to the peptidase S33 family.
CC {ECO:0000256|ARBA:ARBA00010088}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERI75035.1}.
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DR EMBL; AWSU01000272; ERI75035.1; -; Genomic_DNA.
DR RefSeq; WP_021640656.1; NZ_KE992799.1.
DR AlphaFoldDB; U2BS34; -.
DR PATRIC; fig|411472.5.peg.3254; -.
DR HOGENOM; CLU_049285_0_0_9; -.
DR Proteomes; UP000016491; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR022742; Hydrolase_4.
DR InterPro; IPR002410; Peptidase_S33.
DR InterPro; IPR005944; Pro_iminopeptidase.
DR PANTHER; PTHR43722; PROLINE IMINOPEPTIDASE; 1.
DR PANTHER; PTHR43722:SF1; PROLINE IMINOPEPTIDASE; 1.
DR Pfam; PF12146; Hydrolase_4; 1.
DR PRINTS; PR00793; PROAMNOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ERI75035.1}.
FT DOMAIN 67..310
FT /note="Serine aminopeptidase S33"
FT /evidence="ECO:0000259|Pfam:PF12146"
SQ SEQUENCE 332 AA; 37711 MW; A31DB00EB9013688 CRC64;
MDTGRKAGMM NRQLDEKIFI EVNGIRQGMF LQSENTENPV LLYLHGGPGS PEIAFTQDYP
TGLEQLFTVC WWEQRGSGIS YSRKVTKETM TIGQMIEDAT AVTNYLRRRF GKEKIYVLGH
SWGSVLGVLT VQKSPELFHG YIGIGQVVCQ SKSECLAYSF MVNEFTAAGD RKMLRRLEKF
PIDRGGEVSF QYLAVRSVGM MKLGIVIMHH LDSMSDCIKI VLRYKGYTLK DKLHFVMGSG
LALKCLWDFV MQTDFVKQVP RLEIPVYIFQ GRFDYQVSYS LAKEFADTVK APVKGFYTFE
NSAHSPCFEE PKKMCHIIRE DVLQGKCGLA DG
//
