ID U2C4A3_CLOSY Unreviewed; 193 AA.
AC U2C4A3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=HTH domain protein {ECO:0000313|EMBL:ERI78878.1};
GN ORFNames=CLOSYM_01268 {ECO:0000313|EMBL:ERI78878.1};
OS [Clostridium] symbiosum ATCC 14940.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=411472 {ECO:0000313|EMBL:ERI78878.1, ECO:0000313|Proteomes:UP000016491};
RN [1] {ECO:0000313|EMBL:ERI78878.1, ECO:0000313|Proteomes:UP000016491}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14940 {ECO:0000313|EMBL:ERI78878.1,
RC ECO:0000313|Proteomes:UP000016491};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERI78878.1}.
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DR EMBL; AWSU01000105; ERI78878.1; -; Genomic_DNA.
DR AlphaFoldDB; U2C4A3; -.
DR PATRIC; fig|411472.5.peg.1181; -.
DR HOGENOM; CLU_108798_0_0_9; -.
DR Proteomes; UP000016491; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR Gene3D; 3.30.1340.20; 3H domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR035922; 3H_dom_sf.
DR InterPro; IPR004173; 3H_domain.
DR InterPro; IPR013196; HTH_11.
DR InterPro; IPR026043; NadR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR40068; TRANSCRIPTION REPRESSOR NIAR-RELATED; 1.
DR PANTHER; PTHR40068:SF1; TRANSCRIPTION REPRESSOR NIAR-RELATED; 1.
DR Pfam; PF02829; 3H; 1.
DR Pfam; PF08279; HTH_11; 1.
DR PIRSF; PIRSF037847; NiaR; 1.
DR SUPFAM; SSF75500; Putative transcriptional regulator TM1602, C-terminal domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PIRSR:PIRSR037847-1};
KW Nickel {ECO:0000256|PIRSR:PIRSR037847-1}.
FT DOMAIN 24..77
FT /note="Helix-turn-helix type 11"
FT /evidence="ECO:0000259|Pfam:PF08279"
FT DOMAIN 88..184
FT /note="3H"
FT /evidence="ECO:0000259|Pfam:PF02829"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 92
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT BINDING 100
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT BINDING 159
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
FT BINDING 161
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR037847-1"
SQ SEQUENCE 193 AA; 21644 MW; CA1425E86E51E743 CRC64;
MGMRLNNNEE SAAGTESALT GTQRRKKILA LMRQTSHPLS GGALGRETGV SRQVVVQDIA
LLRTEGYPIV ATARGYILNE ASQAVRLFKV CHNNDETEDE LKTIVDLGGC VLDVMINHRV
YGKVTAPLNI KNRRDIQIFM NDIESGKSAP LMNVTSGYHF HRVSAEQEEI LDEIEEALRE
KHYLTELMPY EEM
//
