ID U2E1N4_9GAMM Unreviewed; 1157 AA.
AC U2E1N4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Potassium efflux system KefA protein {ECO:0000313|EMBL:ERJ17826.1};
DE EC=2.1.2.11 {ECO:0000313|EMBL:ERJ17826.1};
GN Name=kefA {ECO:0000313|EMBL:ERJ17826.1};
GN ORFNames=SSPSH_003308 {ECO:0000313|EMBL:ERJ17826.1};
OS Salinisphaera shabanensis E1L3A.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Salinisphaerales;
OC Salinisphaeraceae; Salinisphaera.
OX NCBI_TaxID=1033802 {ECO:0000313|EMBL:ERJ17826.1, ECO:0000313|Proteomes:UP000006242};
RN [1] {ECO:0000313|EMBL:ERJ17826.1, ECO:0000313|Proteomes:UP000006242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E1L3A {ECO:0000313|EMBL:ERJ17826.1,
RC ECO:0000313|Proteomes:UP000006242};
RX PubMed=21705588; DOI=10.1128/JB.05459-11;
RA Antunes A., Alam I., Bajic V.B., Stingl U.;
RT "Genome sequence of Salinisphaera shabanensis, a gammaproteobacterium from
RT the harsh, variable environment of the brine-seawater interface of the
RT Shaban Deep in the Red Sea.";
RL J. Bacteriol. 193:4555-4556(2011).
RN [2] {ECO:0000313|EMBL:ERJ17826.1, ECO:0000313|Proteomes:UP000006242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E1L3A {ECO:0000313|EMBL:ERJ17826.1,
RC ECO:0000313|Proteomes:UP000006242};
RX PubMed=24324765;
RA Alam I., Antunes A., Kamau A.A., Ba Alawi W., Kalkatawi M., Stingl U.,
RA Bajic V.B.;
RT "INDIGO - INtegrated Data Warehouse of MIcrobial GenOmes with Examples from
RT the Red Sea Extremophiles.";
RL PLoS ONE 8:E82210-E82210(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERJ17826.1}.
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DR EMBL; AFNV02000027; ERJ17826.1; -; Genomic_DNA.
DR AlphaFoldDB; U2E1N4; -.
DR STRING; 1033802.SSPSH_003308; -.
DR eggNOG; COG3264; Bacteria.
DR Proteomes; UP000006242; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003864; F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF1; MINICONDUCTANCE MECHANOSENSITIVE CHANNEL MSCM; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006242};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:ERJ17826.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..1157
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004626446"
FT TRANSMEM 515..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 820..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 869..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 911..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 940..970
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..266
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 515..854
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 958..1023
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 1033..1112
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 120..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 144..243
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 377..407
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1157 AA; 128640 MW; D3EF2F1CE1B38E13 CRC64;
MAVPVFTRRC MAIRLFQLLL CVIAMHLSLT PAVAQVGSQR ESLDERIADL RSRADAVPAP
ENMDSALREQ VVSTYRQAIS SLETARNARE DTRKLRTQAN EAPALIRELT DELQQIEAAP
SSESLGGLPA STLSSRVDAT SSRMADNQAR LTDLRDQLNH MAQRPDAARA ALADARESLR
SLDSESSVAE RDQPSLLVEA KNAALSARRE ALTAEIERLQ QELNSQDARQ RELEARRALA
EARQARDTEL LASLQMALGQ SQNQTAIELR SASENKLSEL RTAAEPISDT AQRNVELADQ
LTRITAQTES LANEQVRQHT RVDDLQRRLS LVQRQLEIGG SSVALGDVLR AQRRDLARPG
LLSTRSRSTS DTAQPEIASA ELQRFQLQQQ RTDLEDIDRR VAEIVAESPE LDDGQKSSLA
GLLRHRRKVL DLLISAEGRY IEIGRDLIRL STEYKQTVDS FNRLLDERLF WLPSFGTMGF
DWFARTAQHL PWAFNWSSWT RALERLVDGA RSRPFVTAVG LAFIAVLLLV RRPLRGRLRR
LAEPVGKVQH DTFWVTLRAA LVTVLLFIPP VATLLLAGYL VRTPAGADVF TNAVSAVFIQ
AAILVLFLEP FAQVCRKYGL AESHFQWPEE ARHGLYRMLR WLLAMLVIPT VLVTFTEAFD
DDSKRETIGR GAFMLSLLFI AVFSWRLLHP TRGELAGVIN PEEGSAWRLG YLWLPIAVGV
PLLLFGLAGM GYYYTALQLQ SRFFYSAGLL GGGFVLYALI VRWLTVAERR LALTRALRKR
EEAREARATR DAAAAAGEST PENLDTLEID LVQISEQTRG LVKVVIALLS VAGLWVIWSD
TLPALQLLDN VTLWQYANEV DGRTQLTQVT LGALLLAMAL GVVTALAGRN LPGFLEITVL
RRFSMDAGSR YAMATLFQYA IVIMGMLGAV ALIGFRWSSI QWLVAAVGVG LGFGLQEIFA
NFVSGIVILF ERPVRVGDTV TVGTLTGTVS RIRIRATTVT DWDNKEVVIP NKTFITETVI
NWTLTDDITR LILRVHLALD TDTELAEKLI MDVIKDDPVA LEQPAPTVFF VGYDASALIY
EARIFYHDLY NLLPLQHAIY KGMHAAFRAN DVVVSFPQQD LHLRSVDNSF AKVFRGSPGQ
DEATRSDDDS APTPAGR
//