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Database: UniProt
Entry: U2F1C0_CLOS4
LinkDB: U2F1C0_CLOS4
Original site: U2F1C0_CLOS4 
ID   U2F1C0_CLOS4            Unreviewed;       445 AA.
AC   U2F1C0;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   05-JUL-2017, entry version 31.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF0262_00355 {ECO:0000313|EMBL:ERJ00913.1};
OS   Clostridium sp. (strain ATCC 29733 / VPI C48-50).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1507 {ECO:0000313|EMBL:ERJ00913.1, ECO:0000313|Proteomes:UP000016486};
RN   [1] {ECO:0000313|EMBL:ERJ00913.1, ECO:0000313|Proteomes:UP000016486}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29733 {ECO:0000313|EMBL:ERJ00913.1,
RC   ECO:0000313|Proteomes:UP000016486};
RA   Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R.,
RA   Fronick C., O'Laughlin M., Godfrey J., Miner T., Herter B.,
RA   Appelbaum E., Cordes M., Lek S., Wollam A., Pepin K.H., Palsikar V.B.,
RA   Mitreva M., Wilson R.K.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ERJ00913.1}.
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DR   EMBL; AWTA01000010; ERJ00913.1; -; Genomic_DNA.
DR   RefSeq; WP_021660071.1; NZ_KE993596.1.
DR   EnsemblBacteria; ERJ00913; ERJ00913; HMPREF0262_00355.
DR   PATRIC; fig|1507.3.peg.306; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000016486; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016486};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016486}.
FT   DOMAIN      141    270       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      353    422       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     149    156       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      422    445       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   445 AA;  49982 MW;  8C075811A4AC69F8 CRC64;
     MDSFSDVWEL VAHHCKTQLS DMVYDLWIKC IEPVKLENDT ALLYVRSKFQ QDLINEKYLE
     IIKQGFESVL GFPVAVQITC DAMVKGDGAA AKEENKQPEE ALNQVGIGGD YDYTFASFIV
     GSSNNFAHAA AMAVAANPSN VYNPLFIYGD SGLGKTHLLF AICNEVKKNN PQANIVYVKG
     EEFTNEMISA IGSGTTMEFR NKYRVADVLL IDDIQFIGGK ISTQEEFFHT FETLFQSHKQ
     IVLSSDRPPK EIKTLEDRLR SRFESGLLAD IQPPDFETRI AIIRRKAELL GLDLPSDVTE
     FIANRIKNNI RQLEGAVKKI NAYKMLEGIS PTVAVAHAAI KDILNDNQPI PVTVERIISE
     VSRTFNVSPQ DIKSKKKSAD VSQARQVAIY VIREVTQMPM KNIGEELGGR DHSTIVYSLN
     EMKSKLKKNQ RLQETINDII KNIKK
//
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