ID U2GR28_9CORY Unreviewed; 938 AA.
AC U2GR28;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Cation:proton antiporter {ECO:0000313|EMBL:ERJ45787.1};
GN ORFNames=N579_04945 {ECO:0000313|EMBL:ERJ45787.1};
OS Corynebacterium pseudodiphtheriticum 090104.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1381111 {ECO:0000313|EMBL:ERJ45787.1, ECO:0000313|Proteomes:UP000016653};
RN [1] {ECO:0000313|EMBL:ERJ45787.1, ECO:0000313|Proteomes:UP000016653}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=090104 {ECO:0000313|EMBL:ERJ45787.1,
RC ECO:0000313|Proteomes:UP000016653};
RX PubMed=24201200;
RA Karlyshev A.V., Melnikov V.G.;
RT "Draft Genome Sequence of Corynebacterium pseudodiphtheriticum Strain
RT 090104 'Sokolov'.";
RL Genome Announc. 1:e00921-13(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERJ45787.1}.
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DR EMBL; AVFF01000019; ERJ45787.1; -; Genomic_DNA.
DR AlphaFoldDB; U2GR28; -.
DR PATRIC; fig|1381111.3.peg.982; -.
DR Proteomes; UP000016653; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR001516; Proton_antipo_N.
DR PANTHER; PTHR43373:SF1; ANTIPORTER SUBUNIT MNHA2-RELATED; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 70..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 592..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 618..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 675..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..759
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 808..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..103
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 119..410
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 601..664
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 678..757
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 782..897
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
FT REGION 913..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 938 AA; 100087 MW; 8AF6BC0FC3566E9E CRC64;
MIFSLLALLG VTVASAPLLS RLLGRNAGWV LALPLIVATI MGVAVYDGIH TESVPWIPSL
GVDFNVRLDG LSFVFLLLVL VIGAGVLMYS TRYLHHEDSA FYFFITGFAA AMALLVTTDN
LFVFYVAWEM TTLCSFFLIG NSGEKGQQPA IRTLLVTVLG GLLLLTATII MSVSTATLQL
SEVIASDYWA DNPGTLTVVA MLIAGAAFTK SAQFPFQAWL PDSMVAIAPV SAYLHAAAMV
KAGIYLILRY SPLFGEVAIW NILLIVCGLF TAGFGAMTAV TRDDLKELLA YSTMSQLGLL
VATVGIGTDA ALTAAIVHTI AHACFKAALF MSVGIVEHES GTRLYSELHY VRTKMPVTKT
LVVIAATSMA GIPLLFGFVS KEGLIEAALD APFGDNMNVL ITAGVVVTSM FTFVYSFKYI
IGVFGARGSV AETDVNKTVP EAAFTFWVIP ALLALLTLAL GLYPGAVDNL VDDAALAVTG
ADQHVHLAIW HGFNMALGMS VLIVLVGIVL VLNRDQLFRA MSVFGAPLTG LYVVEFLRQG
IINTGGKYFT AATGTTSMRR HLVLPLLGVI TLAVIGIFTL NDLPEVVGER AWAIDWIFVL
LVAMGCMATV MAKSRLTVVV VVSIAGFGMT LWFYVLGAAD VANTQLTVEI LTVCVLVLIL
HRLPDHFTPD TRRSHFWSIV LSVAVGISTM LAVLALTGRR EISDVSEYFL RETEELTGGS
NIVNVILVEF RAFDTLGELT VLGVAGIAIA VLLSNNRLLA VHDTHMDKHS PLIDARANSV
FLRSTSKLVG PIIVALSILL FFRGHNEAGG GFVAALIASA GFALVYLAAP SNAEAKIRLP
YMALIGGGIT VAVATGLLGF VEGSFLRPLD THIFGLHLST ALLFDLGVYL AVIGMILAAF
NLLGMPRLNS DEADAREPGA DADLADRSLE AEPQAERN
//
