ID U2HFJ6_9BURK Unreviewed; 765 AA.
AC U2HFJ6;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Tyrosine-protein kinase Wzc {ECO:0000313|EMBL:ERJ36968.1};
GN ORFNames=L810_8749 {ECO:0000313|EMBL:ERJ36968.1};
OS Burkholderia sp. AU4i.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=1335308 {ECO:0000313|EMBL:ERJ36968.1, ECO:0000313|Proteomes:UP000016616};
RN [1] {ECO:0000313|EMBL:ERJ36968.1, ECO:0000313|Proteomes:UP000016616}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AU4i {ECO:0000313|EMBL:ERJ36968.1,
RC ECO:0000313|Proteomes:UP000016616};
RA Devi U., Khatri I., Kumar N., Kumar L., Singh D., Sharma D.,
RA Subramanian S., Saini A.K.;
RT "Genome Assembly of Burkholderia vietnamiensis AU4i.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERJ36968.1}.
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DR EMBL; ASSI01000096; ERJ36968.1; -; Genomic_DNA.
DR RefSeq; WP_021160552.1; NZ_ASSI01000096.1.
DR AlphaFoldDB; U2HFJ6; -.
DR PATRIC; fig|1335308.3.peg.4650; -.
DR Proteomes; UP000016616; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR005700; EPS_ExoP-like.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR NCBIfam; TIGR01005; eps_transp_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ERJ36968.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..109
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 388..468
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 555..673
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 290..354
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 765 AA; 82643 MW; 15EE1B273EAE07E6 CRC64;
MTSTPSHEHA HDRDAELDLA GAIDVLVSRR WLIAAVTAAC MGAGTLYAFL APRQYQADIM
VQVEDSGDTS AAKSALGDVS SLFDIKSSAA AEAQILASRL VVTRAVDELR SYIVVQPKRF
PVIGEFVSRF NTGIARPGLL GIGGYAWGTE SATLARFDVP KALEGERFEL SLLDSWRYRL
TGAALPKPVT GTFGHPESFA TAYGPIAIEV TRIDALPDTR FTLMRESRAG TIDALRRGLD
VQEKIKQSGV IVATLRGADP QRVQAQLQAL ASHYVRQHIE RKSADAAQSL AFLNAQLPVL
KKQLQDAEQR YTDMRNANGA IDLDEEAKLI LQQSADAKTR RLELEQKRDA MNARFAPGHP
DMIALDAQIA TLAREQQSFE RQVGRLPDLQ QNAVRLMLDV KVDTDLYTAL LANAQQLELV
KAGKTGSVRL VDTPIAPEDP VRPNRPVVIA AAALLGFALG VALAFVRDYL FGGVRSADEI
ERPLGIDVYA TVPASSGQRQ VARRSAQRLP GPHLLSVLQP HDPAVESLRS LRTALRFAMQ
RAPNNVLLLT GPVPGAGKSF VASNFAALLA ANGERVLLVD GDLRRGYLHD ALGVGREAGF
AELLSGTTTP DAAIRRDVIP NLDFIPTGAI PAHPAELLVD ERVGTLLDTL SARYDRVVID
AAPILAVTDA VVLGRHAGTV LLAARAASTR VAELGEAIRR LAHNGVDASG VLLNGVDPRS
GRYGSRYGAY RYTEYCYTPP RRGLTLSIGR SLRSLVARFR RGAPR
//
