ID   U2J521_9FIRM            Unreviewed;       443 AA.
AC   U2J521;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Putative permease {ECO:0000313|EMBL:ERJ81331.1};
GN   ORFNames=HMPREF1987_01770 {ECO:0000313|EMBL:ERJ81331.1};
OS   Peptostreptococcaceae bacterium oral taxon 113 str. W5053.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae.
OX   NCBI_TaxID=1321784 {ECO:0000313|EMBL:ERJ81331.1, ECO:0000313|Proteomes:UP000016618};
RN   [1] {ECO:0000313|EMBL:ERJ81331.1, ECO:0000313|Proteomes:UP000016618}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W5053 {ECO:0000313|EMBL:ERJ81331.1,
RC   ECO:0000313|Proteomes:UP000016618};
RA   Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA   O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA   Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR005353};
CC       Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR005353}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697,
CC       ECO:0000256|PIRNR:PIRNR005353}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ERJ81331.1}.
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DR   EMBL; AWVB01000112; ERJ81331.1; -; Genomic_DNA.
DR   AlphaFoldDB; U2J521; -.
DR   STRING; 1321784.HMPREF1987_01770; -.
DR   PATRIC; fig|1321784.3.peg.1659; -.
DR   eggNOG; COG2252; Bacteria.
DR   HOGENOM; CLU_024508_0_1_9; -.
DR   OrthoDB; 9808458at2; -.
DR   Proteomes; UP000016618; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR   InterPro; IPR045018; Azg-like.
DR   InterPro; IPR026033; Azg-like_bact_archaea.
DR   InterPro; IPR006043; NCS2.
DR   PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR   PANTHER; PTHR43337:SF1; XANTHINE_URACIL PERMEASE C887.17-RELATED; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PIRSF; PIRSF005353; PbuG; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR005353};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005353};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016618};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|PIRNR:PIRNR005353};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|PIRNR:PIRNR005353};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005353}.
FT   TRANSMEM        27..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        56..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        145..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        175..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        250..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        326..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        382..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        423..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   443 AA;  47521 MW;  E11F5CD9793E10FF CRC64;
     MTELSKGGFF ERRFRLSERK TDVKTEFLAG LTTFMTMSYI LAVNPNMLAQ TGMDKGGVFT
     ATIVASVFAM LVMGFYANLP FALAPGMGLN AFFTYTVVLD RGHSWQFALT AVFIEGIIFI
     LMSFFNVREA IFNAIPMSLK KAVSVGIGLF IALIGFVNAG VISSGAGTIL SLGNLLTPGV
     LVTFVGLLVM ALLMAKKVKG ALLYGIIIST VLALILGVTH APENGWIQAP PSLSGVAFKL
     EWKQIFTWDM FAITFTFLFV DLFDTVGTLV GVASKADLLN EKGELPKAGP ALFADSVGTT
     VGALLGTSTV TTFVESASGV TDGGRTGLTS LSVAFFFLIS LFLFPLFSIV PAQATAPALI
     MVGLFMMTPI KDIPFEDYTE SVPAFLTIVM MPFAYSIAEG IAFGMMSYVL IKVISGKHKD
     VSLLMYILAF IFLARIIAPV FGM
//