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Database: UniProt
Entry: U2J595_9SPHI
LinkDB: U2J595_9SPHI
Original site: U2J595_9SPHI 
ID   U2J595_9SPHI            Unreviewed;       475 AA.
AC   U2J595;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=M472_15095 {ECO:0000313|EMBL:ERJ60089.1};
OS   Sphingobacterium paucimobilis HER1398.
OC   Bacteria; Bacteroidetes; Sphingobacteriia; Sphingobacteriales;
OC   Sphingobacteriaceae; Sphingobacterium.
OX   NCBI_TaxID=1346330 {ECO:0000313|EMBL:ERJ60089.1, ECO:0000313|Proteomes:UP000016584};
RN   [1] {ECO:0000313|EMBL:ERJ60089.1, ECO:0000313|Proteomes:UP000016584}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HER1398 {ECO:0000313|EMBL:ERJ60089.1,
RC   ECO:0000313|Proteomes:UP000016584};
RX   PubMed=23929486;
RA   White R.A.III., Suttle C.A.;
RT   "The Draft Genome Sequence of Sphingomonas paucimobilis Strain HER1398
RT   (Proteobacteria), Host to the Giant PAU Phage, Indicates That It Is a
RT   Member of the Genus Sphingobacterium (Bacteroidetes).";
RL   Genome Announc. 1:e00598-13(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ERJ60089.1}.
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DR   EMBL; ATDL01000010; ERJ60089.1; -; Genomic_DNA.
DR   RefSeq; WP_021069589.1; NZ_ATDL01000010.1.
DR   EnsemblBacteria; ERJ60089; ERJ60089; M472_15095.
DR   PATRIC; fig|1346330.5.peg.1408; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000016584; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016584};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016584}.
FT   DOMAIN      171    307       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      382    451       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     179    186       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   475 AA;  54132 MW;  0D2EA78633C59E9D CRC64;
     MEKTYTGVWN NCLQVIKDNI PAQSFKTWFE PVKAIRLEGN VLTIQVPSLF FYEWLEEHYV
     GILRKTVKKF LGEQGRLEYN IVVEKSSTNI PYTTNLPSNG NGAEAKRQSI PVPVALNKNI
     KNPFVIPGLK KLQVDPQLNQ NYTFENFVEG ECNRLARSAG YAVANKPGGT SFNPLMLYGD
     VGLGKTHLAQ AIGNEIKKNL PDKLVIYVSC EKFCQQFVDS LKNNTINDFV NFYQAMDVII
     MDDVHNFAGK EKTQDIFFHV FNHLHQSGKQ IILTSDKPPK DLSGLEERLL SRFKWGLSAD
     IQIPDLETRM AILKKKMYSD GIELPENVVE YVATQIDNSV RELEGAMVSL LAQSTLNKKE
     IDLNLAKSML KNFVKNTHKE ISMEYIQKLV CEYFEVPVEM VKSKVRKREI VQARQISMYL
     AKNHTKSSLK SIGSFFGGRD HSTVIYACQT VEDLIETDKK FKTYVQDIQK KLKTS
//
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