ID U2KEV0_9FIRM Unreviewed; 433 AA.
AC U2KEV0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Hexokinase {ECO:0000313|EMBL:ERJ90620.1};
GN ORFNames=HMPREF1992_01557 {ECO:0000313|EMBL:ERJ90620.1};
OS Selenomonas sp. oral taxon 892 str. F0426.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Selenomonadaceae;
OC Selenomonas.
OX NCBI_TaxID=1321786 {ECO:0000313|EMBL:ERJ90620.1, ECO:0000313|Proteomes:UP000016604};
RN [1] {ECO:0000313|EMBL:ERJ90620.1, ECO:0000313|Proteomes:UP000016604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0426 {ECO:0000313|EMBL:ERJ90620.1,
RC ECO:0000313|Proteomes:UP000016604};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC -!- PATHWAY: Carbohydrate degradation. {ECO:0000256|ARBA:ARBA00004921}.
CC -!- PATHWAY: Carbohydrate metabolism. {ECO:0000256|ARBA:ARBA00005007}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERJ90620.1}.
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DR EMBL; AWVG01000085; ERJ90620.1; -; Genomic_DNA.
DR RefSeq; WP_021684461.1; NZ_KI260533.1.
DR AlphaFoldDB; U2KEV0; -.
DR STRING; 1321786.HMPREF1992_01557; -.
DR PATRIC; fig|1321786.3.peg.1407; -.
DR eggNOG; COG5026; Bacteria.
DR HOGENOM; CLU_014393_5_3_9; -.
DR OrthoDB; 6383434at2; -.
DR UniPathway; UPA00109; UER00180.
DR Proteomes; UP000016604; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ERJ90620.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..205
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 212..425
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 433 AA; 47013 MW; 47D8BD9BAACAB86E CRC64;
MGFDREKFDE IKAAFTIDDD ALRKIADDFR ADMCAGLAGK EGATLRMLRS YADLPSGKET
GSFLALDFGG TNVRALRILL KGGGEYEVLS KVAKPLTLPG VYDYVSADAT AEEMFDFLAE
IIDEAIEGNR TTKYLLGHTF SFPSQQTDLY NAKLIVWTKE FATQGVEGKV VNDLLKEALA
RRGMTNVEPV AVINDTVAVL LAAAYKHEHT YIGSIYATGQ NTCYYEEFAD GSEPPTVINM
ESGGFGKLPF SKYDEILDRE SEQPGAQRLE KMVSGRYLGS LYGAALADLL GTDGVYPFSS
IELSEIIADA YLDRHSAGAV IEAKTGMTFT AAERALLQEL ATAVIVRSAR IVAATYVAII
QHRMGENALE NQFVAVDGSV YEKVPLVAHH LRGALDTLLL DEAVNVKIIL ENTGSALGAA
LAAAMTERNE RIK
//
