ID U2KHE5_9STRE Unreviewed; 1179 AA.
AC U2KHE5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN ORFNames=HMPREF1557_00881 {ECO:0000313|EMBL:ERJ76569.1};
OS Streptococcus sobrinus W1703.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1227275 {ECO:0000313|EMBL:ERJ76569.1, ECO:0000313|Proteomes:UP000016617};
RN [1] {ECO:0000313|EMBL:ERJ76569.1, ECO:0000313|Proteomes:UP000016617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W1703 {ECO:0000313|EMBL:ERJ76569.1,
RC ECO:0000313|Proteomes:UP000016617};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Warren W., Mitreva M., Mardis E.R.,
RA Wilson R.K.;
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERJ76569.1}.
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DR EMBL; AWVA01000053; ERJ76569.1; -; Genomic_DNA.
DR RefSeq; WP_021673271.1; NZ_KI259658.1.
DR AlphaFoldDB; U2KHE5; -.
DR PATRIC; fig|1227275.3.peg.779; -.
DR HOGENOM; CLU_001042_2_2_9; -.
DR OrthoDB; 9808768at2; -.
DR Proteomes; UP000016617; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd03278; ABC_SMC_barmotin; 2.
DR Gene3D; 1.10.287.1490; -; 2.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01894}; Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01894}.
FT DOMAIN 518..637
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 174..489
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 677..728
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 773..1008
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1179 AA; 132352 MW; 16DFAD162D1D024B CRC64;
MFLKEIEMQG FKSFVDKTRI EFDRGVTAVV GPNGSGKSNI TESLRWALGE SSAKSLRGGK
MPDVIFAGTQ DRSPLNFAQV TVVLDNSDNF IKDSGQEIRV ERHIYRNGDS DYLIDGRKVR
LRDIHDLFMD TGLGRDSFSI ISQGRVEAIF NSRPEERRAI FEEAAGVLKY KTRKKETQGK
LDKTQDNLDR LEDIIYELEG QIKPLEKQAT TAKQFLVLDQ ERKSLNLNIL VQDIKAYRAD
LDKSNEQIQL TKNDLKDYYA QRNRLESDNQ RLKERRQNLS QTMDRQQDDL LEVTRLIADY
QRQIEVISLE SSQKAEKKAD AQGRLADLEN QKQDLEASLA QKQEQQAQLA DKLANLRQEI
ADLEKEQSRF STNPDQIIES LREEFVGLMQ KEADLSNRLT ALQADIEQEK SAQEEQSAER
QQVEEDLAQA KEVAQAALAE FQAAQAQVKA LLEDYQAQSQ ELNQTESNYR QEQSQMFALL
DQIKEKEARQ RSLEAIQKNH SNFYAGVKAV LQEADRLGGI IGAVSEHLTF EQDYQTALEI
ALGGSSQNII VEDEAAAKRG IAFLRQNRSG RATFLPLTTI KPRQVAAHNL AKIEAAPGFL
GLASDLVTYD AKLANIFQNL LGVTAIFDDI DHANQAACDV RYQVRMVTLD GTELRPGGSF
SGGANRNRNT TFIKPEMDSL TAEISDLKEK LNQQESVVAK LKTARTQAQE ELTNLKEAGE
NARLAEQKAD LAYQNQADRL ADLNQIKAGF SAHAQGKTDA DLLAEKVKVE SGLTQIQEQK
AHVQEQLDQI KDDKDTITAQ VTKLNEELAQ ARLSERELSG EERFAKNESN RLELELADLE
RNISNLTQVL SSQASDLSQE ELPKLAKQLE EAESKKSDLK TSLIRLRFEV EDCDGQLEDI
EELVQAAGKR NEELIRRQAQ LEAEIDNLSD KLRGFARQLT EDYQMSFDQA KEQAQALEDL
PAARQDLTQL NRQIKALGPI NLDAIDQYDE VNQRLEFLNS QRSDLVEAKN LLLGTINDMD
DEVKSRFKTT FEAIRESFKE TFVQMFGGGS ADLILTEGDL LTAGVEISVQ PPGKKIQSLN
LMSGGEKALS ALALLFSIIR VKTIPFVILD EVEAALDEAN VKRFGDYLNR FDKASQFIVV
THRKGTMAAA DSIYGVTMQE SGVSKIVSVK LKDAQELVG
//
