ID U2NKJ3_9CLOT Unreviewed; 399 AA.
AC U2NKJ3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Mandelate racemase/muconate lactonizing protein {ECO:0000313|EMBL:ERK29391.1};
GN ORFNames=CINTURNW_3399 {ECO:0000313|EMBL:ERK29391.1};
OS Clostridium intestinale URNW.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1294142 {ECO:0000313|EMBL:ERK29391.1, ECO:0000313|Proteomes:UP000016721};
RN [1] {ECO:0000313|EMBL:ERK29391.1, ECO:0000313|Proteomes:UP000016721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=URNW {ECO:0000313|EMBL:ERK29391.1,
RC ECO:0000313|Proteomes:UP000016721};
RX PubMed=24136853;
RA Lal S., Ramachandran U., Zhang X., Sparling R., Levin D.B.;
RT "Draft Genome Sequence of the Hydrogen- and Ethanol-Producing Bacterium
RT Clostridium intestinale Strain URNW.";
RL Genome Announc. 1:e00871-13(2013).
CC -!- FUNCTION: Has no detectable activity with D-mannonate and with a panel
CC of 70 other acid sugars (in vitro), in spite of the conservation of the
CC residues that are expected to be important for catalytic activity and
CC cofactor binding. May have evolved a divergent function.
CC {ECO:0000256|ARBA:ARBA00003553}.
CC -!- SIMILARITY: Belongs to the mandelate racemase/muconate lactonizing
CC enzyme family. GalD subfamily. {ECO:0000256|ARBA:ARBA00010339}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERK29391.1}.
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DR EMBL; APJA01000019; ERK29391.1; -; Genomic_DNA.
DR RefSeq; WP_021803357.1; NZ_KI273145.1.
DR AlphaFoldDB; U2NKJ3; -.
DR STRING; 1294142.CINTURNW_3399; -.
DR PATRIC; fig|1294142.3.peg.3544; -.
DR eggNOG; COG4948; Bacteria.
DR HOGENOM; CLU_030273_6_1_9; -.
DR OrthoDB; 9775391at2; -.
DR Proteomes; UP000016721; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0009063; P:amino acid catabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR034589; D-mannonate_dehydratase-like.
DR InterPro; IPR034593; DgoD-like.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR018110; Mandel_Rmase/mucon_lact_enz_CS.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR PANTHER; PTHR48080; D-GALACTONATE DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR48080:SF6; STARVATION-SENSING PROTEIN RSPA; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SFLD; SFLDG00033; mannonate_dehydratase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
DR PROSITE; PS00908; MR_MLE_1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000016721}.
FT DOMAIN 132..252
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 399 AA; 45222 MW; DF6995B47BEB1388 CRC64;
MTPTIIANVE CFTLKPDRHN LVVVKVTTDK GITGYGCATF QQRPKVVKLM VEEYLRPILI
GKDANNIEDL WHMMMVNSYW RNGPVTNNAV SGVDMALWDI KGKLANMPLY QLFGGKSRDA
IPAYTHAVAD NIDDLYKEVD SILAEGYKHI RCQLGFYGGN PTNLHCPENP TPGSYYDQDD
YIDTTLNMFS LLREKYGNKF HILHDIHERL FPNQAVQFAK DVEKFKPYFI EDILAPDQNE
WLGQIRAQTS TPIASGELFN NPMEWKHLIA ERKIDFLRCH VSQIGGITPA LKLGALCESF
GIRIAWHTPS DITPIGIAVN THLNIHLYSA AIQENIPINP NTRSVFSNIV EARNGYIYPI
EAPGIGVDFN EEKALEFPIE YRMHEWTQAR IPDGSIMTP
//
