ID U2NX56_ENTFC Unreviewed; 206 AA.
AC U2NX56;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Probable DNA-directed RNA polymerase subunit delta {ECO:0000256|HAMAP-Rule:MF_00357};
DE AltName: Full=RNAP delta factor {ECO:0000256|HAMAP-Rule:MF_00357};
GN Name=rpoE {ECO:0000256|HAMAP-Rule:MF_00357};
GN ORFNames=I131_06335 {ECO:0000313|EMBL:ERK33668.1};
OS Enterococcus faecium CRL1879.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1295527 {ECO:0000313|EMBL:ERK33668.1, ECO:0000313|Proteomes:UP000016582};
RN [1] {ECO:0000313|EMBL:ERK33668.1, ECO:0000313|Proteomes:UP000016582}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CRL1879 {ECO:0000313|EMBL:ERK33668.1,
RC ECO:0000313|Proteomes:UP000016582};
RX PubMed=23868133;
RA Suarez N.E., Saavedra L., Slozilova I., Bonacina J., Demnerova K.,
RA Sesma F.;
RT "Draft Genome Sequence of Enterococcus faecium Strain CRL 1879, Isolated
RT from a Northwestern Argentinian Artisanal Cheese.";
RL Genome Announc. 1:E00514-13(2013).
CC -!- FUNCTION: Participates in both the initiation and recycling phases of
CC transcription. In the presence of the delta subunit, RNAP displays an
CC increased specificity of transcription, a decreased affinity for
CC nucleic acids, and an increased efficiency of RNA synthesis because of
CC enhanced recycling. {ECO:0000256|HAMAP-Rule:MF_00357}.
CC -!- SUBUNIT: RNAP is composed of a core of 2 alpha, a beta and a beta'
CC subunits. The core is associated with a delta subunit and one of
CC several sigma factors. {ECO:0000256|HAMAP-Rule:MF_00357}.
CC -!- SIMILARITY: Belongs to the RpoE family. {ECO:0000256|ARBA:ARBA00009828,
CC ECO:0000256|HAMAP-Rule:MF_00357}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERK33668.1}.
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DR EMBL; AOUK01000053; ERK33668.1; -; Genomic_DNA.
DR AlphaFoldDB; U2NX56; -.
DR Proteomes; UP000016582; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.1250; RNA polymerase, subunit delta, N-terminal domain; 1.
DR HAMAP; MF_00357; RNApol_bact_RpoE; 1.
DR InterPro; IPR007759; Asxl_HARE-HTH.
DR InterPro; IPR038087; RNAP_delta_N_dom_sf.
DR InterPro; IPR029757; RpoE.
DR NCBIfam; TIGR04567; RNAP_delt_lowGC; 1.
DR Pfam; PF05066; HARE-HTH; 1.
DR PROSITE; PS51913; HTH_HARE; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|HAMAP-Rule:MF_00357};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_00357};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00357};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00357}.
FT DOMAIN 14..81
FT /note="HTH HARE-type"
FT /evidence="ECO:0000259|PROSITE:PS51913"
FT REGION 93..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..156
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..206
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 206 AA; 23683 MW; 51B44DB643FF189A CRC64;
MEISVFEGAN KSELSMIEVA HAILEQRGDV MDFSDLANQI QNYLGKSDSE IRDSLAQFYT
DLNIDGSFIS LGDNRWGLRS WYAIDSIDEE VNHGMDEEDE DTPRRRKRKK VNAFINDDED
AIDYNDDDPE DTDLTEEDDD DLFDDDDDED EEIAAYNSDL QEIGADDPTD DEEDLPGNIE
EDLSIIDEDD DDEDYEEEEF SDSEKE
//
