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Database: UniProt
Entry: U2TID4_9ACTN
LinkDB: U2TID4_9ACTN
Original site: U2TID4_9ACTN 
ID   U2TID4_9ACTN            Unreviewed;       495 AA.
AC   U2TID4;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   05-JUL-2017, entry version 29.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   ORFNames=HMPREF1316_0803 {ECO:0000313|EMBL:ERL05978.1};
OS   Olsenella profusa F0195.
OC   Bacteria; Actinobacteria; Coriobacteriia; Coriobacteriales;
OC   Atopobiaceae; Olsenella.
OX   NCBI_TaxID=1125712 {ECO:0000313|EMBL:ERL05978.1, ECO:0000313|Proteomes:UP000016638};
RN   [1] {ECO:0000313|EMBL:ERL05978.1, ECO:0000313|Proteomes:UP000016638}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0195 {ECO:0000313|EMBL:ERL05978.1,
RC   ECO:0000313|Proteomes:UP000016638};
RA   Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M.,
RA   Haft D.H., Methe B., Sutton G., Nelson K.E.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ERL05978.1}.
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DR   EMBL; AWEZ01000073; ERL05978.1; -; Genomic_DNA.
DR   RefSeq; WP_021727363.1; NZ_AWEZ01000073.1.
DR   EnsemblBacteria; ERL05978; ERL05978; HMPREF1316_0803.
DR   PATRIC; fig|1125712.3.peg.2475; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000016638; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016638};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016638}.
FT   DOMAIN      168    311       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      401    470       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   495 AA;  55030 MW;  903DB1E354352FBD CRC64;
     MAKEDGQLLW ADALTLIEAT NMQPATIAML KSCEVEDFSG DTLTISTGLG FARMRIQRES
     DTIERLLEEA AFQPVHLVVE LTARAREPKA SISNEITQAE AQHLQTSAVT ATSGAAAATP
     MAPNLSTLLD DPAAVRESKL TFERFVAGEE NMLAFEAAKQ VANGENKGYN PLFIFGKSGL
     GKTHLLRAIQ NYIVLNDSSR ACSYRTAAEF VEDYRIAWND KETSARSALS TNYQSVDVLI
     IDDVQNMSTA AGSIRFFFET FNALMARGKQ IVLAADRSPL QLGMGESKFD ERETSRMDSG
     VTVSIQVPDY ELKLNLINTF YERMRQDAEC EHIGGMSGTI SKEMRRLMAE RAGTNIRTME
     GFVQTCIINA TRLGEKGQDL GRDDIIRIAA AKWPSAQRTI SIEQIQKAVE SYYDVSHDDL
     VGAKRNKEVV EPRHVCIWLV RELTDNTLAD IGKRFGGRSH ATVKHSIKWV ETTRKEDRIF
     LDHLESIKDS IIAKS
//
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