ID U2V6U9_9ACTN Unreviewed; 272 AA.
AC U2V6U9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN Name=thyA {ECO:0000313|EMBL:ERL08351.1};
GN ORFNames=HMPREF1316_0173 {ECO:0000313|EMBL:ERL08351.1};
OS Olsenella profusa F0195.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC Olsenella.
OX NCBI_TaxID=1125712 {ECO:0000313|EMBL:ERL08351.1, ECO:0000313|Proteomes:UP000016638};
RN [1] {ECO:0000313|EMBL:ERL08351.1, ECO:0000313|Proteomes:UP000016638}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0195 {ECO:0000313|EMBL:ERL08351.1,
RC ECO:0000313|Proteomes:UP000016638};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERL08351.1}.
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DR EMBL; AWEZ01000045; ERL08351.1; -; Genomic_DNA.
DR AlphaFoldDB; U2V6U9; -.
DR STRING; 1125712.HMPREF1316_0173; -.
DR PATRIC; fig|1125712.3.peg.1299; -.
DR eggNOG; COG0207; Bacteria.
DR Proteomes; UP000016638; Unassembled WGS sequence.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ERL08351.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016638};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ERL08351.1}.
FT DOMAIN 1..266
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 272 AA; 31431 MW; AD86D94C6A5F30D5 CRC64;
MCTDIIEHGV TTEGQRVRPH WPDGTPAYTI KRFGICNRYD LREEFPALTL RRTALKSAMD
EILWIYQRKS NDIHDLNSHI WDEWADETGS IGKAYGYQVG QVSHYPDGDF DQMDRVLKDL
RENPYSRRIM TNLYTFSDLS EMHLYPCAYN AIYNVTQEPG VEKPTLNMLL VQRSQDVLAA
NNWNVCQYAL LLMMVAQSVD MVAGELVHMI ADAHIYDRHV DIVRELVRRP HHPAPHVALN
PLVTNFYDFT TDDLIVEGYE HGPQVRDIPI AI
//
