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Database: UniProt
Entry: U2XAE8_9MICO
LinkDB: U2XAE8_9MICO
Original site: U2XAE8_9MICO 
ID   U2XAE8_9MICO            Unreviewed;       459 AA.
AC   U2XAE8;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   05-JUL-2017, entry version 29.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:GAD34556.1};
GN   ORFNames=MTS1_01923 {ECO:0000313|EMBL:GAD34556.1};
OS   Microbacterium sp. TS-1.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae;
OC   Microbacterium.
OX   NCBI_TaxID=1344956 {ECO:0000313|EMBL:GAD34556.1, ECO:0000313|Proteomes:UP000018080};
RN   [1] {ECO:0000313|EMBL:GAD34556.1, ECO:0000313|Proteomes:UP000018080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TS-1 {ECO:0000313|EMBL:GAD34556.1,
RC   ECO:0000313|Proteomes:UP000018080};
RA   Fujinami S., Takeda K., Onodera T., Satoh K., Sano M., Narumi I.,
RA   Ito M.;
RT   "Draft Genome Sequence of Sodium-Independent Alkaliphilic
RT   Microbacterium sp. Strain TS-1.";
RL   Genome Announc. 1:e01043-13(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAD34556.1}.
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DR   EMBL; BASQ01000001; GAD34556.1; -; Genomic_DNA.
DR   EnsemblBacteria; GAD34556; GAD34556; MTS1_01923.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000018080; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018080};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018080}.
FT   DOMAIN      154    282       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      366    435       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     162    169       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   459 AA;  51191 MW;  F95D742EA2A2F28A CRC64;
     MWNAVLDLLA DDDRVTPQMQ GFLSLAVAQG VMGGTLYLDV PNDLTAAQLN KRLRQPIMEA
     LAHVHVEPGA SSYRVVVNPE LADAHLTAPI PVQSAAAPAP LRPAGEEYVE APVSTSRHDT
     RLNPKYTFDN FVIGQSNRFA HAAAVAVAEA PAKAYNPLFI YGDSGLGKTH LLHAIGDYAL
     NLYTGIRVRY VSSEEFTNDF INSIANNRGS AFQARYREVD ILLIDDIQFL QGRAETQEAF
     FHTFNTLHDH DKQVVITSDV PPRHLTGFED RMRSRFEWGL ITDVQAPDLE TRIAILRKKA
     QSERLLVPDD VLEYIATKVS SNIRELEGAL IRVSAFASLN RSNLDISLAQ TVLRDIVDQD
     DANVISPTDI INATAQYFRL SVDDLYGSSR SQAVATARQI AMYLCRERTS LSLPKIGQLF
     GNRDHTTVMY AYKKISELMK ERRSIYNQVS EITSQLGRR
//
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