ID U2YAN7_GEOKU Unreviewed; 360 AA.
AC U2YAN7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Aldose 1-epimerase {ECO:0000256|ARBA:ARBA00014165, ECO:0000256|PIRNR:PIRNR005096};
DE EC=5.1.3.3 {ECO:0000256|ARBA:ARBA00013185, ECO:0000256|PIRNR:PIRNR005096};
GN ORFNames=GBL_2150 {ECO:0000313|EMBL:GAD13933.1};
OS Geobacillus kaustophilus GBlys.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC Geobacillus thermoleovorans group.
OX NCBI_TaxID=1337888 {ECO:0000313|EMBL:GAD13933.1, ECO:0000313|Proteomes:UP000016424};
RN [1] {ECO:0000313|Proteomes:UP000016424}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GBlys {ECO:0000313|Proteomes:UP000016424};
RA Doi K., Mori K., Martono H., Nagayoshi Y., Fujino Y., Tashiro K.,
RA Kuhara S., Ohshima T.;
RT "Draft Genome Sequence of Geobacillus kaustophilus GBlys, a Lysogenic
RT Strain with Bacteriophage phiOH2.";
RL Genome Announc.1:e00634-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose = beta-D-glucose; Xref=Rhea:RHEA:10264,
CC ChEBI:CHEBI:15903, ChEBI:CHEBI:17925; EC=5.1.3.3;
CC Evidence={ECO:0000256|ARBA:ARBA00001614,
CC ECO:0000256|PIRNR:PIRNR005096};
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028, ECO:0000256|PIRNR:PIRNR005096}.
CC -!- SIMILARITY: Belongs to the aldose epimerase family.
CC {ECO:0000256|ARBA:ARBA00006206, ECO:0000256|PIRNR:PIRNR005096}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD13933.1}.
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DR EMBL; BASG01000020; GAD13933.1; -; Genomic_DNA.
DR AlphaFoldDB; U2YAN7; -.
DR UniPathway; UPA00242; -.
DR Proteomes; UP000016424; Unassembled WGS sequence.
DR GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR018052; Ald1_epimerase_CS.
DR InterPro; IPR015443; Aldose_1-epimerase.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR PANTHER; PTHR10091:SF50; ALDOSE 1-EPIMERASE; 1.
DR PANTHER; PTHR10091; ALDOSE-1-EPIMERASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR PIRSF; PIRSF005096; GALM; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR PROSITE; PS00545; ALDOSE_1_EPIMERASE; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|PIRNR:PIRNR005096};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|PIRNR:PIRNR005096}.
FT ACT_SITE 189
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT ACT_SITE 323
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
FT BINDING 189..191
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-3"
FT BINDING 262
FT /ligand="beta-D-galactose"
FT /ligand_id="ChEBI:CHEBI:27667"
FT /evidence="ECO:0000256|PIRSR:PIRSR005096-2"
SQ SEQUENCE 360 AA; 40449 MW; 25DBCBA78089DD9E CRC64;
MYGYEGRRIE MNITYEKWSE WNGNDVFLFT LTNDRGMGLS ATNYGCIVTD LRVPDRNGNI
ENVVLGFGRF ELYLTNAPYF GAVIGRVAGR IRGASFELEG VTYRLAKNEH NNHLHGGPNG
FHRVLWQAEP VQRDDAVGVV FSYTSPDGEE GYQGTVHVQV EYWLNNDNEW IVTHRARSDK
TTLVNLTNHT YFNLSGNGKR DILDHTLTIQ SSRVLELNEE LIPTGRVLDV AGTPFDLRQG
KMIREAVESG HPQIELVGGG YDHPFWLDRH HDKEIVLSDQ ESGRTLTVET DEVGVVVYTS
NQLPEGMDLG GVPSRKYLGV CLETQGLPDA IHHPQFPSII LPADKERVST TVYRFGGRTS
//
