ID   U2YJ58_9SPHN            Unreviewed;       734 AA.
AC   U2YJ58;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE            EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN   ORFNames=NT2_02_02940 {ECO:0000313|EMBL:GAD48212.1};
OS   Caenibius tardaugens NBRC 16725.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Erythrobacteraceae; Caenibius.
OX   NCBI_TaxID=1219035 {ECO:0000313|EMBL:GAD48212.1, ECO:0000313|Proteomes:UP000016568};
RN   [1] {ECO:0000313|EMBL:GAD48212.1, ECO:0000313|Proteomes:UP000016568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 16725 {ECO:0000313|EMBL:GAD48212.1,
RC   ECO:0000313|Proteomes:UP000016568};
RA   Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Ando Y., Yamazaki S.,
RA   Fujita N.;
RT   "Whole genome shotgun sequence of Novosphingobium tardaugens NBRC 16725.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC         EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAD48212.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BASZ01000002; GAD48212.1; -; Genomic_DNA.
DR   AlphaFoldDB; U2YJ58; -.
DR   eggNOG; COG1505; Bacteria.
DR   Proteomes; UP000016568; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016568};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..734
FT                   /note="prolyl oligopeptidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004636310"
FT   DOMAIN          48..453
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          515..727
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   734 AA;  81111 MW;  542BCC1C0345BFA8 CRC64;
     MRSLTRPVAG ALVLSLATVQ LAIAADMANP VSAGAAPVPA TNPAITYPQT RRDNVNDVLF
     GETIADPYRW LENDVRNTPE VADWVARENV VTDAYLRTLP GRAWFSEKIG QLMNYERFSI
     PVKAGGQYFY ERNEGLQNQP QLFVRKGLNG KPRLLLDPVQ WSKDGTSALD AWKPSPDGRY
     VLYSVQEDGS DWRRLEVLDV RTGKRLSDTV RWAKFTSLAW VGEEGFLYSR FPEPEGGQDF
     QALNYNQAVY FHRLGTDQSV DERVFATPDH KERSHTAEVT YDGRWAVITS AIGTDSKYEV
     HAIDLAKRAQ KGWFARPLIT GFDNAWNLIE GTGGVLWFTT NEDAPRFRIV AIDLDAGAPR
     WYEVVRQSPE TINAASLVGN RLVVSYLKDA ASRALIFELG GTRVDEIRLN GLGTANGFTG
     KPGDPETFYS FASFNRPAGI YRMDLATGRM QPFALPKLTF DPDAYAVEQR FFTSKDGTNV
     PMFVVRKRSV AEAGKAVPTM LYGYGGFDVS VTPGFSAVRM AWLEAGGAFA LANIRGGGEY
     GKAWHDAGRL ANKQNVFDDF IAAGEYLKRE GITSPDGLAI EGRSNGGLLM GAVTNQRPDL
     FNAVHAAVGV MDMLRFDRWT AGRYWVDDYG HPDRKEDFTI LRSYSPYHNI RAGVDYPAII
     VTTADTDDRV VPGHSFKYAA ALQAAPIGNK PHLIRIETGA GHGSGKPTDK QIAEGADVLA
     FLARWTGLDV RSEK
//