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Database: UniProt
Entry: U3B2T1_9VIBR
LinkDB: U3B2T1_9VIBR
Original site: U3B2T1_9VIBR 
ID   U3B2T1_9VIBR            Unreviewed;      1548 AA.
AC   U3B2T1;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
GN   ORFNames=VEZ01S_20_00340 {ECO:0000313|EMBL:GAD79762.1};
OS   Vibrio ezurae NBRC 102218.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=1219080 {ECO:0000313|EMBL:GAD79762.1, ECO:0000313|Proteomes:UP000016562};
RN   [1] {ECO:0000313|EMBL:GAD79762.1, ECO:0000313|Proteomes:UP000016562}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 102218 {ECO:0000313|EMBL:GAD79762.1,
RC   ECO:0000313|Proteomes:UP000016562};
RA   Yoshida I., Hosoyama A., Numata M., Hashimoto M., Hosoyama Y.,
RA   Tsuchikane K., Noguchi M., Hirakata S., Ichikawa N., Ohji S., Yamazoe A.,
RA   Fujita N.;
RT   "Whole genome shotgun sequence of Vibrio ezurae NBRC 102218.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAD79762.1}.
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DR   EMBL; BATM01000020; GAD79762.1; -; Genomic_DNA.
DR   RefSeq; WP_021713471.1; NZ_BATM01000020.1.
DR   STRING; 1219080.VEZ01S_20_00340; -.
DR   eggNOG; COG2373; Bacteria.
DR   OrthoDB; 9767116at2; -.
DR   Proteomes; UP000016562; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd02891; A2M_like; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR041203; Bact_A2M_MG5.
DR   InterPro; IPR041462; Bact_A2M_MG6.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF17972; bMG5; 1.
DR   Pfam; PF17962; bMG6; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016562};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..1548
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004640106"
FT   DOMAIN          687..827
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          889..979
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   1548 AA;  172943 MW;  54B903A1A4BD702B CRC64;
     MRIHRKLFIQ FFTLIYMLAF AGGVFAATVT NVTEGKINGK TSIVVSLKGA LSHPLDLPVV
     KDKKRVHRAW VLSEDRTFQS LSIDDFGVGE YSVSLAGFDR EDLRSLETIN IYEASPSVRV
     LGQGPFINAT GDRAIPIESV NATGVLASIY RVDDTPKLFA DYFYSQTLSN WSAQRLRKNF
     THQTDLSFKL PAAKENASTV TNLKLPDNLA NGWYIIAIKP SNSFDSPDIF HVLLSDIGVQ
     AKVFDKKVSL QAVDLATHKP LQSAKVSIVG QDGVRDTAYL KDGFVQFDYG ERSSEDVFVV
     QSGASVAVLP MKEVPLDLSD FKVDGQQSKS LNGYIFSNRD LFKPGEEVPL NIVLRKESGE
     ITALNSLFME VIAPDGKVIL SRNIEESQKG FFNYRFTIPA SAKLGKWSAV VRSTRQSKAV
     IGSFNFNVQE FVPERMDLTV SVPHLVMAGE PIKGQASGRY LFGQVADGNR LTISSTLRSI
     ASFPGKYAHY LVGKQKYISS SNAPDDIDLK LDKQGKAHFS LSAISKDALD GPAMLTTNNQ
     LFETGGATTT RVNKLLVSNG KSIVGLKPNS EDFGYFTEAK FSLLLLDDKG ENTLSGDVRI
     KVERNRGGYY WVFNQSSGWD LRRDDNWRVT ESKVMHVNAQ HNELVVPVEW GDYRITAVAP
     SGQETVYSLY AGWEDGDTQI PVKPDQLSMK LDKESYLAGD YINVQVASPR AGLVSLELVA
     DKTYLHKTVQ VKGKQNIRLR LPSNIDRHDL YLIGSLVNSD KAYVRRSLAV APVKLFRDHR
     KLAVSIQAPE RLEPFTTQTV KVKVDNAANL KDAYVVLTVA DKGIINMSHY KVADIFNWFY
     GQKRLGADII DLYSRQFESR PSPFIRHRYG GDEGINSSKP LNNLVESKTF NQVLPAVKLN
     QKGEANIQLQ VPDYNGEVQM VAMVFAGAKF GQKVQDVTVS APIVAELSVP RFFATNNHSQ
     VMVEASNQTK EMQKVTLSLH ADDGIRLVGQ SAKVLELAPQ QKAHFAVQVD AGNKVTMTNL
     TLSVNSRAYQ IERNWRVPVR SPSPYVTKKT TRTLAVGDFV NITRSQWQGV LPKDHGISTV
     SFSRVPEIEP TAFVQGLFNY PYGCVEQTTS TGYPWLLDDA SLVPLKKEVL EERSDVDMLQ
     KAVLRLADYQ NGKGGFGLWG SYSQEEPWLT SYVASFLFTV NERYPNMVSN SVLDKITRRM
     RQYIYGDLNQ EVGINDQAYA AYVLTQAGKL SFSDAKTYLK KVPVFNSLSN AYLGAVFYRL
     GDMRSSRDYF RQAGYAIELH DDNYYDSSLS ARAKIVSIVS DLEKQGPINR QMSELRIESA
     KAIFKALNKR RYFSTQERYA LAKAGFDLQA LNKKPIQISK NGQLVPSSKA VSMQLGDRFQ
     NESHDVAYVT ESIDGYADPN ALQSSVEFKL VSRTYFDSKG KRLNRATLHV GDRIIAKVVV
     NLKENIDKAM LVDYLPAGMV LENPDFTDSK ELLKSLDFVS SGAEMEEFRN DRYVTSLDFS
     RGYEYTFYYV MRAETQGISE VPNLFIEDMY APERFVYQPG SVSSIQIK
//
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