ID U3B2T1_9VIBR Unreviewed; 1548 AA.
AC U3B2T1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
GN ORFNames=VEZ01S_20_00340 {ECO:0000313|EMBL:GAD79762.1};
OS Vibrio ezurae NBRC 102218.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=1219080 {ECO:0000313|EMBL:GAD79762.1, ECO:0000313|Proteomes:UP000016562};
RN [1] {ECO:0000313|EMBL:GAD79762.1, ECO:0000313|Proteomes:UP000016562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 102218 {ECO:0000313|EMBL:GAD79762.1,
RC ECO:0000313|Proteomes:UP000016562};
RA Yoshida I., Hosoyama A., Numata M., Hashimoto M., Hosoyama Y.,
RA Tsuchikane K., Noguchi M., Hirakata S., Ichikawa N., Ohji S., Yamazoe A.,
RA Fujita N.;
RT "Whole genome shotgun sequence of Vibrio ezurae NBRC 102218.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD79762.1}.
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DR EMBL; BATM01000020; GAD79762.1; -; Genomic_DNA.
DR RefSeq; WP_021713471.1; NZ_BATM01000020.1.
DR STRING; 1219080.VEZ01S_20_00340; -.
DR eggNOG; COG2373; Bacteria.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000016562; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000016562};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1548
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004640106"
FT DOMAIN 687..827
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 889..979
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1548 AA; 172943 MW; 54B903A1A4BD702B CRC64;
MRIHRKLFIQ FFTLIYMLAF AGGVFAATVT NVTEGKINGK TSIVVSLKGA LSHPLDLPVV
KDKKRVHRAW VLSEDRTFQS LSIDDFGVGE YSVSLAGFDR EDLRSLETIN IYEASPSVRV
LGQGPFINAT GDRAIPIESV NATGVLASIY RVDDTPKLFA DYFYSQTLSN WSAQRLRKNF
THQTDLSFKL PAAKENASTV TNLKLPDNLA NGWYIIAIKP SNSFDSPDIF HVLLSDIGVQ
AKVFDKKVSL QAVDLATHKP LQSAKVSIVG QDGVRDTAYL KDGFVQFDYG ERSSEDVFVV
QSGASVAVLP MKEVPLDLSD FKVDGQQSKS LNGYIFSNRD LFKPGEEVPL NIVLRKESGE
ITALNSLFME VIAPDGKVIL SRNIEESQKG FFNYRFTIPA SAKLGKWSAV VRSTRQSKAV
IGSFNFNVQE FVPERMDLTV SVPHLVMAGE PIKGQASGRY LFGQVADGNR LTISSTLRSI
ASFPGKYAHY LVGKQKYISS SNAPDDIDLK LDKQGKAHFS LSAISKDALD GPAMLTTNNQ
LFETGGATTT RVNKLLVSNG KSIVGLKPNS EDFGYFTEAK FSLLLLDDKG ENTLSGDVRI
KVERNRGGYY WVFNQSSGWD LRRDDNWRVT ESKVMHVNAQ HNELVVPVEW GDYRITAVAP
SGQETVYSLY AGWEDGDTQI PVKPDQLSMK LDKESYLAGD YINVQVASPR AGLVSLELVA
DKTYLHKTVQ VKGKQNIRLR LPSNIDRHDL YLIGSLVNSD KAYVRRSLAV APVKLFRDHR
KLAVSIQAPE RLEPFTTQTV KVKVDNAANL KDAYVVLTVA DKGIINMSHY KVADIFNWFY
GQKRLGADII DLYSRQFESR PSPFIRHRYG GDEGINSSKP LNNLVESKTF NQVLPAVKLN
QKGEANIQLQ VPDYNGEVQM VAMVFAGAKF GQKVQDVTVS APIVAELSVP RFFATNNHSQ
VMVEASNQTK EMQKVTLSLH ADDGIRLVGQ SAKVLELAPQ QKAHFAVQVD AGNKVTMTNL
TLSVNSRAYQ IERNWRVPVR SPSPYVTKKT TRTLAVGDFV NITRSQWQGV LPKDHGISTV
SFSRVPEIEP TAFVQGLFNY PYGCVEQTTS TGYPWLLDDA SLVPLKKEVL EERSDVDMLQ
KAVLRLADYQ NGKGGFGLWG SYSQEEPWLT SYVASFLFTV NERYPNMVSN SVLDKITRRM
RQYIYGDLNQ EVGINDQAYA AYVLTQAGKL SFSDAKTYLK KVPVFNSLSN AYLGAVFYRL
GDMRSSRDYF RQAGYAIELH DDNYYDSSLS ARAKIVSIVS DLEKQGPINR QMSELRIESA
KAIFKALNKR RYFSTQERYA LAKAGFDLQA LNKKPIQISK NGQLVPSSKA VSMQLGDRFQ
NESHDVAYVT ESIDGYADPN ALQSSVEFKL VSRTYFDSKG KRLNRATLHV GDRIIAKVVV
NLKENIDKAM LVDYLPAGMV LENPDFTDSK ELLKSLDFVS SGAEMEEFRN DRYVTSLDFS
RGYEYTFYYV MRAETQGISE VPNLFIEDMY APERFVYQPG SVSSIQIK
//