ID U3B8P4_CALJA Unreviewed; 1117 AA.
AC U3B8P4; F7I558;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Cytospin-A {ECO:0000256|ARBA:ARBA00015657, ECO:0000256|RuleBase:RU367063};
GN Name=SPECC1L {ECO:0000313|EMBL:JAB02502.1,
GN ECO:0000313|Ensembl:ENSCJAP00000093948.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB02502.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000093948.1, ECO:0000313|Proteomes:UP000008225}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB02502.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB02502.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB51856.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB28261.1}, Hippocampus
RC {ECO:0000313|EMBL:JAB19027.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB36927.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000093948.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in cytokinesis and spindle organization. May play a
CC role in actin cytoskeleton organization and microtubule stabilization
CC and hence required for proper cell adhesion and migration.
CC {ECO:0000256|ARBA:ARBA00025131, ECO:0000256|RuleBase:RU367063}.
CC -!- SUBUNIT: May interact with both microtubules and actin cytoskeleton.
CC {ECO:0000256|ARBA:ARBA00011235, ECO:0000256|RuleBase:RU367063}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186, ECO:0000256|RuleBase:RU367063}.
CC Cytoplasm, cytoskeleton {ECO:0000256|RuleBase:RU367063}. Cell junction,
CC gap junction {ECO:0000256|RuleBase:RU367063}.
CC -!- SIMILARITY: Belongs to the cytospin-A family.
CC {ECO:0000256|ARBA:ARBA00009452, ECO:0000256|RuleBase:RU367063}.
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DR EMBL; GAMT01009359; JAB02502.1; -; mRNA.
DR EMBL; GAMS01004109; JAB19027.1; -; mRNA.
DR EMBL; GAMR01005671; JAB28261.1; -; mRNA.
DR EMBL; GAMQ01004924; JAB36927.1; -; mRNA.
DR EMBL; GAMP01000899; JAB51856.1; -; mRNA.
DR STRING; 9483.ENSCJAP00000017790; -.
DR Ensembl; ENSCJAT00000118013.1; ENSCJAP00000093948.1; ENSCJAG00000009691.5.
DR GeneTree; ENSGT00940000153592; -.
DR OrthoDB; 5393863at2759; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000009691; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR CDD; cd21199; CH_CYTS; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR PANTHER; PTHR23167; CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED; 1.
DR PANTHER; PTHR23167:SF18; CYTOSPIN-A; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|RuleBase:RU367063};
KW Cell division {ECO:0000256|RuleBase:RU367063};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949,
KW ECO:0000256|RuleBase:RU367063}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU367063};
KW Cytoskeleton {ECO:0000256|RuleBase:RU367063};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW ECO:0000256|RuleBase:RU367063};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 1011..1116
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 243..270
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 400..441
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 488..805
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 11..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..990
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1117 AA; 124515 MW; F33445AE500A70A6 CRC64;
MRKASRSVGS VPKVSGISKT QTAEKIKPEN SSSASTGGKP VKPGTAASLS KTKSSDDLLA
GMAGGVTVTN GVKGKKSTCP SAAPSASAPA MTTVENKSKI STGTASSTKR STSTGNKESS
STRERLRERT RLNQSKKLPS AGQGANDVAL AKRSRSRTAT ECDVRMSKSK SDNQISDKAA
LEAKVKDLLT LAKTKDVEIL HLRNELRDMR AQLGISEEHS EGDEKSEKET IIAHQPTDVE
STLLQLQEQN TAIREELNQL KNENRMLKDR LNALGFSLEQ RLDNSEKLFG YQSLSPEITP
GNQSDGGGTL TSSVEGSAPG SVEDLLSQDE NTLMDHQHSN SMDNLDSECS EVYQPLTSSD
DALDAPSSSE SEGIPSIERS RKGSSGNASE VSVACLTERI HQMEENQHST SEELQATLQE
LADLQQITQE LNSENERLGE EKVILMESLC QQSDKLEHFS RQIEYFRSLL DEHHISYVID
EDVKSGRYME LEQRYMDLAE NARFEREQLL GVQQHLSNTL KMAEQDNKEA QEMIGALKER
SHHMERIIES EQKGKAALAA TLEEYKATVA SDQIEMNRLK AQLENEKQKV TELYSIHNSG
DKSDIQDLLE SVRLDKEKAE TLASSLQEDL AHTQNDANRL QDALAKVEDE YRAFQEDAKK
QIEDLNMTLE KLRSELDEKE TERSDMKETI FELEDEVEQH RAVKLHDNLI ISDLENTVKK
LQDQKHDMER EIKTLHRRLR EESAEWRQFQ ADLQTAVVIA NDIKSEAQEE IGDLKRRLHE
AQEKNEKLTK ELEEIKSRKQ EEERGRVYNY MNAVERDLAA LRQGMGLSRR SSTSSEPTPT
VKTLIKSFDS ASQVPNPAAA AIPRTPLSPS PMKTPPAAAV SPMQRHSISG PISTSKPLTA
LSDKRPNYGE IPVQEHLLRT SSTSRPASLP RVPAMESAKT LSVSRRSSEE MKRDISAQEG
ASPASLMAMG TTSPQLSLSS SPTASVTPTT RSRIREERKD PLSALAREYG GSKRNALLKW
CQKKTEGYQN IDITNFSSSW NDGLAFCALL HTYLPAHIPY QELNSQDKRR NFMLAFQAAE
SVGIKSTLDI NEMVRTERPD WQNVMLYVTA IYKYFET
//
