ID U3BH17_VIBPR Unreviewed; 739 AA.
AC U3BH17;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN Name=relA {ECO:0000313|EMBL:GAD68954.1};
GN ORFNames=VPR01S_21_00390 {ECO:0000313|EMBL:GAD68954.1};
OS Vibrio proteolyticus NBRC 13287.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=1219065 {ECO:0000313|EMBL:GAD68954.1, ECO:0000313|Proteomes:UP000016570};
RN [1] {ECO:0000313|EMBL:GAD68954.1, ECO:0000313|Proteomes:UP000016570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 13287 {ECO:0000313|EMBL:GAD68954.1,
RC ECO:0000313|Proteomes:UP000016570};
RA Isaki S., Hosoyama A., Numata M., Hashimoto M., Hosoyama Y., Tsuchikane K.,
RA Noguchi M., Hirakata S., Ichikawa N., Ohji S., Yamazoe A., Fujita N.;
RT "Whole genome shotgun sequence of Vibrio proteolyticus NBRC 13287.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAD68954.1}.
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DR EMBL; BATJ01000021; GAD68954.1; -; Genomic_DNA.
DR RefSeq; WP_021706922.1; NZ_BATJ01000021.1.
DR AlphaFoldDB; U3BH17; -.
DR STRING; 1219065.VPR01S_21_00390; -.
DR eggNOG; COG0317; Bacteria.
DR Proteomes; UP000016570; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:GAD68954.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016570};
KW Transferase {ECO:0000313|EMBL:GAD68954.1}.
FT DOMAIN 54..159
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 400..461
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 665..739
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 739 AA; 84047 MW; DB056B443C4EBF66 CRC64;
MVAVRSAHLN QDEQFELEKW ISSLKQDKET ANRLSNVYRQ CEELLNGTEQ GPLLLWRGRE
MIEILITLSM DRATLVAAQL FPIVTSGLFE RELLEEHYGK EIIKLIDGVE EMAAIGQLNV
TMSGGAASAQ VDNVRRMLLA MVDDFRCVVI KLAERICNLI EVKKAPDEVR RAAAKECANI
YAPLANRLGI GQLKWEIEDY AFRYQHPDTY KQIAKQLAER RIVREQYIKD FVDDLAEEMA
VCGINAEVSG RPKHIYSIWR KMQKKNLAFD ELFDVRAVRI IADKLQDCYA ALGVVHTKYK
HLPSEFDDYV ANPKPNGYQS IHTVILGPEG KTIEIQIRTK QMHEESELGV AAHWKYKEGS
SARSGYDEKI TWLRKLLDWQ EEMSDSGEML DELRSQVFDD RVYAFTPRGD VVDLPMGATP
LDFAYHIHSE VGHRCIGAKV AGRIVPFTHK LHMGDQVEII TSKEPNPSRD WLNPSLGFVH
SGRARAKINA WFRKQSREKN LEAGREILER ELVKIGATLK DAEQYALKRF NVNTPDELYV
GVGSGDLRIN QIINHINALV NKPTAEEEDL QALEKLQEAE NRAPAQSRPK KDAVVVEGVD
NLLTHLARCC HPIPGDDICG YITQGRGISV HRSDCEQLDE LRHHAPERII DTVWGSGFVG
SYILTVRVEA MERGGLVKDI TTLFANEKIK VTSMKSRIDY RSQLSIMDFD LEVNNLEVLN
RIVKRVEQIR DVMSVKRLG
//