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Database: UniProt
Entry: U3BH17_VIBPR
LinkDB: U3BH17_VIBPR
Original site: U3BH17_VIBPR 
ID   U3BH17_VIBPR            Unreviewed;       739 AA.
AC   U3BH17;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE   AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE   AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE   AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN   Name=relA {ECO:0000313|EMBL:GAD68954.1};
GN   ORFNames=VPR01S_21_00390 {ECO:0000313|EMBL:GAD68954.1};
OS   Vibrio proteolyticus NBRC 13287.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=1219065 {ECO:0000313|EMBL:GAD68954.1, ECO:0000313|Proteomes:UP000016570};
RN   [1] {ECO:0000313|EMBL:GAD68954.1, ECO:0000313|Proteomes:UP000016570}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 13287 {ECO:0000313|EMBL:GAD68954.1,
RC   ECO:0000313|Proteomes:UP000016570};
RA   Isaki S., Hosoyama A., Numata M., Hashimoto M., Hosoyama Y., Tsuchikane K.,
RA   Noguchi M., Hirakata S., Ichikawa N., Ohji S., Yamazoe A., Fujita N.;
RT   "Whole genome shotgun sequence of Vibrio proteolyticus NBRC 13287.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC       is a mediator of the stringent response that coordinates a variety of
CC       cellular activities in response to changes in nutritional abundance.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAD68954.1}.
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DR   EMBL; BATJ01000021; GAD68954.1; -; Genomic_DNA.
DR   RefSeq; WP_021706922.1; NZ_BATJ01000021.1.
DR   AlphaFoldDB; U3BH17; -.
DR   STRING; 1219065.VPR01S_21_00390; -.
DR   eggNOG; COG0317; Bacteria.
DR   Proteomes; UP000016570; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd04876; ACT_RelA-SpoT; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RSH; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA/SpoT.
DR   NCBIfam; TIGR00691; spoT_relA; 1.
DR   PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF19296; RelA_AH_RIS; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81271; TGS-like; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:GAD68954.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016570};
KW   Transferase {ECO:0000313|EMBL:GAD68954.1}.
FT   DOMAIN          54..159
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   DOMAIN          400..461
FT                   /note="TGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51880"
FT   DOMAIN          665..739
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   739 AA;  84047 MW;  DB056B443C4EBF66 CRC64;
     MVAVRSAHLN QDEQFELEKW ISSLKQDKET ANRLSNVYRQ CEELLNGTEQ GPLLLWRGRE
     MIEILITLSM DRATLVAAQL FPIVTSGLFE RELLEEHYGK EIIKLIDGVE EMAAIGQLNV
     TMSGGAASAQ VDNVRRMLLA MVDDFRCVVI KLAERICNLI EVKKAPDEVR RAAAKECANI
     YAPLANRLGI GQLKWEIEDY AFRYQHPDTY KQIAKQLAER RIVREQYIKD FVDDLAEEMA
     VCGINAEVSG RPKHIYSIWR KMQKKNLAFD ELFDVRAVRI IADKLQDCYA ALGVVHTKYK
     HLPSEFDDYV ANPKPNGYQS IHTVILGPEG KTIEIQIRTK QMHEESELGV AAHWKYKEGS
     SARSGYDEKI TWLRKLLDWQ EEMSDSGEML DELRSQVFDD RVYAFTPRGD VVDLPMGATP
     LDFAYHIHSE VGHRCIGAKV AGRIVPFTHK LHMGDQVEII TSKEPNPSRD WLNPSLGFVH
     SGRARAKINA WFRKQSREKN LEAGREILER ELVKIGATLK DAEQYALKRF NVNTPDELYV
     GVGSGDLRIN QIINHINALV NKPTAEEEDL QALEKLQEAE NRAPAQSRPK KDAVVVEGVD
     NLLTHLARCC HPIPGDDICG YITQGRGISV HRSDCEQLDE LRHHAPERII DTVWGSGFVG
     SYILTVRVEA MERGGLVKDI TTLFANEKIK VTSMKSRIDY RSQLSIMDFD LEVNNLEVLN
     RIVKRVEQIR DVMSVKRLG
//
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