ID U3C4X3_CALJA Unreviewed; 1862 AA.
AC U3C4X3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Ankyrin-2 isoform 3 {ECO:0000313|EMBL:JAB20453.1};
GN Name=ANK2 {ECO:0000313|EMBL:JAB20453.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB20453.1};
RN [1] {ECO:0000313|EMBL:JAB20453.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Hippocampus {ECO:0000313|EMBL:JAB20453.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAMS01002683; JAB20453.1; -; mRNA.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 3.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 3.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 42..74
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 75..107
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 108..140
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 211..243
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 244..276
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 277..309
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 310..342
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 343..375
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 376..408
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 409..441
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 442..474
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 475..507
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 508..540
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 541..573
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 574..606
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 607..639
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 640..672
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 673..705
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 706..738
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 739..771
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 959..1147
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1149..1295
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1475..1559
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1449..1473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1628..1659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1681..1753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1642..1659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1681..1705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1714..1728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1734..1748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1862 AA; 204610 MW; 1917722D31802D77 CRC64;
MTTMLQKSDS NASFLRAARA GNLDKVVEYL KGGIDINTCN QNGLNALHLA AKEGHVGLVQ
ELLGRGSSVD SATKKGNTAL HIASLAGQAE VVKVLVKEGA NINAQSQNGF TPLYMAAQEN
HIDVVKYLLE NGANQSTATE DGFTPLAVAL QQGHNQAVAI LLENDTKGKV RLPALHIAAR
KDDTKSAALL LQNDHNADVQ SKMMVNRTTE SGFTPLHIAA HYGNVNVATL LLNRGAAVDF
TARNGITPLH VASKRGNTNM VKLLLDRGGQ IDAKTRDGLT PLHCAARSGH DQVVELLLER
GAPLLARTKN GLSPLHMAAQ GDHVECVKHL LQHKAPVDDV TLDYLTALHV AAHCGHYRVT
KLLLDKRANP NARALNGFTP LHIACKKNRI KVMELLVKYG ASIQAITESG LTPIHVAAFM
GHLNIVLLLL QNGASPDVTN IRGETALHMA ARAGQVEVVR CLLRNGALVD ARAREEQTPL
HIASRLGKTE IVQLLLQHMA HPDAATTNGY TPLHISAREG QVDVASVLLE AGAAHSLATK
KGFTPLHVAA KYGSLDVAKL LLQRRAAADS AGKNGLTPLH VAAHYDNQKV ALLLLEKGAS
PHATAKNGYT PLHIAAKKNQ MQIASTLLNY GAETNIVTKQ GVTPLHLASQ EGHTDMVTLL
LDKGANIHMS TKSGLTSLHL AAQEDKVNVA DILTKHGADQ DAHTKLGYTP LIVACHYGNV
KMVNFLLKQG ANVNAKTKNG YTPLHQAAQQ GHTHIINVLL QHGAKPNATT ANGNTALAIA
KRLGYISVVD TLKVVTEEVT TTTTTITEKH KLNVPETMTE VLDVSDEEGD DTMTGDGGEY
LRPEDLKELG DDSLPSSQFL DGMNYLRYSL EGGRSDSLRS FSSDRSHTLS HASYLRDSAV
MDDSVVIPSH QVSALAKEAE RNSYRLSWGT ENLDNVALSS SPIHSGRASP CLDRDNSSFL
VSFMVDARGG AMRGCRHNGL RIIIPPRKCT APTRVTCRLV KRHRLATMPP MVEGEGLASR
LIEVGPSGAQ FLGKLHLPTA PPPLNEGESL VSRILQLGPP GTKFLGPVIV EIPHFAALRG
KERELVVLRS ENGDSWKEHF CDYTEDELNE ILNGMDEVLD SPEDLEKKRI CRIITRDFPQ
YFAVVSRIKQ DSNLIGPEGG VLSSTVVPQV QAVFPEGALT KRIRVGLQAQ PMHSELVKKI
LGNKATFSPI VTLEPRRRKF HKPITMTIPV PKASSDVMLN GFGGDAPTLR LLCSITGGTT
PAQWEDITGT TPLTFVNECV SFTTNVSARF WLIDCRQIQE SVTFASQVYR EIICVPYMAK
FVVFAKSHDP IEARLRCFCM TDDKVDKTLE QQENFAEVAR SRDVEVLEGK PIYVDCFGNL
VPLTKSGQHH IFSFFAFKEN RLPLFVKVRD TTQEPCGRLS FMKEPKSTRG LVHQAICNLN
ITLPIYTKES ESDQEQEEEI DMTSEKNPQD EQERIEERLA YIADHLGFSW TELARELDFT
EEQIHQIRIE NPNSLQDQSH ALLKYWLERD GKHATDTNLI ECLTKINRMD IVHLMETNTE
PLQERISHSY AEIEQTITLD HSEGFSVLQE ELCTAQHKQK EEQAVSKESE TCHPPIVSEE
DISVGYSTFQ DGIPKTEGDS PATALFPQTH KEQVQQDFSG KMQDLPEESS LEYQQEYFVT
SPGTEASETQ KPTAVPDSPS KTPEEVSTPP EEERLYLQTP TSSERGGSPI IQEPDEPSEH
REESSPRKTS LVIVESADNQ LETCERVDED AAFEKGDDMP EIPPETVTEE EYIDEHGHTV
VKKVTRKIIR RYVSSEGTEK EEIMVQGMPQ EPVNIEEGDG YSKVIKRVVL KSDTKQSEDN
NE
//
