ID U3CHB6_CALJA Unreviewed; 310 AA.
AC U3CHB6; F7DIU3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=GPN-loop GTPase 2 {ECO:0000256|ARBA:ARBA00014588, ECO:0000256|RuleBase:RU365059};
GN Name=GPN2 {ECO:0000313|EMBL:JAB17749.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB17749.1};
RN [1] {ECO:0000313|EMBL:JAB17749.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB01618.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB42337.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB31223.1}, Hippocampus
RC {ECO:0000313|EMBL:JAB17749.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB35330.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
CC -!- FUNCTION: Small GTPase required for proper localization of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|ARBA:ARBA00003181,
CC ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; GAMT01010243; JAB01618.1; -; mRNA.
DR EMBL; GAMS01005387; JAB17749.1; -; mRNA.
DR EMBL; GAMR01002709; JAB31223.1; -; mRNA.
DR EMBL; GAMQ01006521; JAB35330.1; -; mRNA.
DR EMBL; GAMP01010418; JAB42337.1; -; mRNA.
DR AlphaFoldDB; U3CHB6; -.
DR STRING; 9483.ENSCJAP00000018357; -.
DR InParanoid; U3CHB6; -.
DR Bgee; ENSCJAG00000009981; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17871; GPN2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030231; Gpn2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF3; GPN-LOOP GTPASE 2; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 2: Evidence at transcript level;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059}.
SQ SEQUENCE 310 AA; 34395 MW; E2F16E2A8C168B68 CRC64;
MAGAAPTTAF GQAVIGPPGS GKTTYCLGMS EFLRALGRRV AVVNLDPANE GLPYECAVDV
GELVGLGDVM DALRLGPNGG LLYCMEYLEA NLDWLRAKLD PLRGHYFLFD CPGQVELCTH
HGALRSIFSQ MAQWDLRLTA VHLVDSHYCT DPAKFISVLC TSLATMLHVE LPHVNLLSKM
DLIEHYGKLA FNLDYYTEVL DLSYLLDHLA SDPFFCHYRQ LNEKLVQLIE DYSLVSFIPL
NIQDKESIQR VLQAVDKANG YCFGAQEQRS LEAMMSAAMG ADFHFSSTLG IQEKYLAPSD
QSVEQEAMQL
//
