ID U3DQX3_CALJA Unreviewed; 646 AA.
AC U3DQX3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Cell surface glycoprotein MUC18 {ECO:0000313|EMBL:JAB41088.1};
GN Name=MCAM {ECO:0000313|EMBL:JAB41088.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB41088.1};
RN [1] {ECO:0000313|EMBL:JAB41088.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Hippocampus {ECO:0000313|EMBL:JAB20841.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB41088.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAMS01002295; JAB20841.1; -; mRNA.
DR EMBL; GAMS01002294; JAB20842.1; -; mRNA.
DR EMBL; GAMQ01000763; JAB41088.1; -; mRNA.
DR AlphaFoldDB; U3DQX3; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11973:SF18; CELL SURFACE GLYCOPROTEIN MUC18; 1.
DR PANTHER; PTHR11973; CELL SURFACE GLYCOPROTEIN MUC18-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..646
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010152427"
FT TRANSMEM 560..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..129
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 139..242
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 244..321
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 344..424
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 430..510
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 525..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 71560 MW; 9289A69457638CB1 CRC64;
MGLPRLICAF LLYACCCCRR AAGVPGEAEQ PAPELVEVEV GSTALLKCSL FQSQGNFSHV
DWFSVHKEKR VLIFRVRQGQ GQSEPGEYQH RLSLQDRGAT LALTQVTPHD ERIFLCQGKR
PRSQEHRIQL RVYKAPEEPN IQANALGIPV NSKEPSEVAT CVGRNGYPIP QVIWYKNGRP
LKEEKNRVHI QSSQTVESSG LYTLQSILKA QLVKEDKDAQ FYCELNYRLP SGNHMKESRE
VTVPVFYPTE KVWLEVEPVG MLKEGDRVEI RCLADGNPPP HFSISKQNLS TREAEEETTV
DNGVLVLEPA RKEHSGLYEC QGLDLDTMIS LPSEAQELLV NYVSDVQVSP ADPERQEGSS
LTLTCEAESS QALEFQWLRE ETGQVLERGS VLRLHNLKRE AGGGYRCMAS VPSIPGLNRT
QLVNVAIFGP PWMAFKERKL WVKENTVLNL SCEASGHPRP TISWNVNGTA SEQDQDPQRV
LSTLNVLVTP ELLKTGVECT ASNDLGKNTS VLFLELVNLT TLTPDSNTTT GLSTSTASPH
TKANSTSTER KLPEPESQGV VIVAVIVCIL VLAVLGAILY FLYKKGKLPC GRSGKQEITL
PPSRKSEFVV EVKSDKLPEE MGLLQGSSGD KRAPGDQGEK YIDLRH
//
