ID   U3DYY0_CALJA            Unreviewed;       963 AA.
AC   U3DYY0; F7ITD9;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=SH3 domain-binding protein 4 {ECO:0000313|EMBL:JAB18556.1, ECO:0000313|Ensembl:ENSCJAP00000026249.3};
GN   Name=SH3BP4 {ECO:0000313|EMBL:JAB18556.1,
GN   ECO:0000313|Ensembl:ENSCJAP00000026249.3};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB18556.1};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000026249.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:JAB18556.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Bladder {ECO:0000313|EMBL:JAB05999.1}, and Hippocampus
RC   {ECO:0000313|EMBL:JAB18556.1};
RX   PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA   Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA   Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT   "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT   sequences.";
RL   Gigascience 3:14-14(2014).
RN   [3] {ECO:0000313|Ensembl:ENSCJAP00000026249.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC       {ECO:0000256|ARBA:ARBA00004132}. Membrane, clathrin-coated pit
CC       {ECO:0000256|ARBA:ARBA00004600}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GAMT01005862; JAB05999.1; -; mRNA.
DR   EMBL; GAMS01004580; JAB18556.1; -; mRNA.
DR   STRING; 9483.ENSCJAP00000026249; -.
DR   Ensembl; ENSCJAT00000027738.5; ENSCJAP00000026249.3; ENSCJAG00000014272.5.
DR   eggNOG; ENOG502QTUW; Eukaryota.
DR   GeneTree; ENSGT00390000013151; -.
DR   HOGENOM; CLU_013080_2_0_1; -.
DR   OMA; HRIRANN; -.
DR   OrthoDB; 4019548at2759; -.
DR   TreeFam; TF105572; -.
DR   Proteomes; UP000008225; Chromosome 6.
DR   Bgee; ENSCJAG00000014272; Expressed in testis and 6 other cell types or tissues.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:Ensembl.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   GO; GO:0061462; P:protein localization to lysosome; IEA:Ensembl.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR15603:SF3; SH3 DOMAIN-BINDING PROTEIN 4; 1.
DR   PANTHER; PTHR15603; SH3 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   2: Evidence at transcript level;
KW   Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW   Membrane {ECO:0000256|ARBA:ARBA00023176};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          55..114
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          317..454
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
FT   DOMAIN          654..724
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
SQ   SEQUENCE   963 AA;  107495 MW;  29A242EDE869351A CRC64;
     MAAQRIRAAN SSGLPRCKSE GTLIDLSEGF SETSFNDVKV PSPSALLVDN PTPFGNAKEV
     IAIKDYCPTN FTTLKFSKGD HLYVLDTSGG EWWYAHNTTE IGYIPSSYVQ PLNYRNSTLS
     DSGMIDNLPD SPDEVAKELD LLGGWTDDKK VPARRYSNNP FWNGAQTNPF LNGNAPVMPS
     VDEPNPKSTV DLLLFDTGTA SFTESSSATT NSTGNIFDEL PVTNGLHTEP PVKRDNPFFR
     SKRSYSLSEL SVLQAKSDTP TSPSFFTGLK SPAPEQFQSR EDFRAAWLNH RKLARSCHDL
     DLLGQSPGWG QTQAVETNIV CKLDSSGGTV QLPDTGISIH VPEGHVTPGE MQQISLRALL
     DPPLELNSDR SCSISPVLEV KLSNLEVKTS IILEMKVSAE IKNDLFSKST VGLQCLRSDS
     KEGPYASVPL SYGCGDTVQA QLHNLEPCMY VAIVAHGPSI LYPSTVWDFI HKKVTVGLYG
     PKHIHPSFKT VVTIFGHDCA PKTLLVSEVT RQAPSPAPVA LQLWGKHQFI LPRPQDLKVC
     MFSNMMNYEV RASEQAKVVR GFQLKLGKVS RLIFPIASQN ANELSDFTLR VQVKDDQEAI
     LTQFCVQTPQ PPPKSAIKPS GQRRFLKKNE VGKIILSPFA TTTKYPTFQD RPVSSLKFGK
     LLKTVVRQNK NHYLLEYKKG DGIALLSEER VRLRGQLWTK EWYIGYYQGR VGLVHAKNVL
     VVGRARPSLC SGPELSTSVL LEQILRPCKF LTYIYASVRT LLMENISSWR SFADALGYVN
     LPLTFFCRAE LDSEPERVAC VLEKLKEDCN NMESKERKSF QKELVMALLK MDCQGLVVRL
     IQDFVLLTTA VEVAHRWREL AEKLAKVSKQ QMDAYESPHR DRNGVVDSEA MWKPAYDFLL
     TWSHQIGDSY RDVIQELHLG LDKMKNPITK RWKHLTGTLI LVNSLDILRA AAFSPADQDD
     FVI
//