ID U3EBP4_CALJA Unreviewed; 1174 AA.
AC U3EBP4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Calcium-activated potassium channel subunit alpha-1 {ECO:0000256|ARBA:ARBA00018044};
DE AltName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
DE AltName: Full=BKCA alpha {ECO:0000256|ARBA:ARBA00030518};
DE AltName: Full=Calcium-activated potassium channel, subfamily M subunit alpha-1 {ECO:0000256|ARBA:ARBA00030288};
DE AltName: Full=K(VCA)alpha {ECO:0000256|ARBA:ARBA00031597};
DE AltName: Full=KCa1.1 {ECO:0000256|ARBA:ARBA00030652};
DE AltName: Full=Maxi K channel {ECO:0000256|ARBA:ARBA00031999};
DE AltName: Full=Slo-alpha {ECO:0000256|ARBA:ARBA00029583};
DE AltName: Full=Slo1 {ECO:0000256|ARBA:ARBA00030326};
DE AltName: Full=Slowpoke homolog {ECO:0000256|ARBA:ARBA00033447};
GN Name=KCNMA1 {ECO:0000313|EMBL:JAB39629.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB39629.1};
RN [1] {ECO:0000313|EMBL:JAB39629.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAB39629.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. Calcium-activated
CC (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00008648}.
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DR EMBL; GAMQ01002222; JAB39629.1; -; mRNA.
DR AlphaFoldDB; U3EBP4; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022839; F:monoatomic ion-gated channel activity; IEA:UniProt.
DR GO; GO:0005267; F:potassium channel activity; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF28; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000313|EMBL:JAB39629.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 82..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 177..392
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 542..629
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 994..1114
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 130664 MW; 9B167FF63DD73E27 CRC64;
MANGGGGGGG NSGGGGGGGG SSLRMSSNIH ANHLSLDASS SSSSSSSSSS SSSSSSVHEP
KMDALIIPVT MEVPCDSRGQ RMWWAFLASS MVTFFGGLFI ILLWRTLKYL WTVCCHCGGK
TKEAQKINNG SSQADGTLKP VDEKEEAVAA EVGWMTSVKD WAGVMISAQT LTGRVLVVLV
FALSIGALVI YFIDSSNPIE SCQNFYKDFT LQIDMAFNVF FLLYFGLRFI AANDKLWFWL
EVNSVVDFFT VPPVFVSVYL NRSWLGLRFL RALRLIQFSE ILQFLNILKT SNSIKLVNLL
SIFISTWLTA AGFIHLVENS GDPWENFQNN QALTYWECVY LLMVTMSTVG YGDVYAKTTL
GRLFMVFFIL GGLAMFASYV PEIIELIGNR KKYGGSYSAV SGRKHIVVCG HITLESVSNF
LKDFLHKDRD DVNVEIVFLH NISPNLELEA LFKRHFTQVE FYQGSVLNPH DLARVKIESA
DACLILANKY CADPDAEDAS NIMRVISIKN YHPKIRIITQ MLQYHNKAHL LNIPSWNWKE
GDDAICLAEL KLGFIAQSCL AQGLSTMLAN LFSMRSFIKI EEDTWQKYYL EGVSNEMYTE
YLSSAFVGLS FPTVCELCFV KLKLLMIAIE YKSANRESRI LINPGNHLKI QEGTLGFFIA
SDAKEVKRAF FYCKACHDDI TDPKRIKKCG CKRLEDEQPS TLSPKKKQRN GGMRNSPNTS
PKLMRHDPLL IPGNDQIDNM DSNVKKYDST GMFHWCAPKD IEKVILTRSE AAMTVLSGHV
VVCIFGDVSS ALIGLRNLVM PLRASNFHYH ELKHIVFVGS IEYLKREWET LHNFPKVSIL
PGTPLSRADL RAVNINLCDM CVILSANQNN IDDTSLQDKE CILASLNIKS MQFDDSIGVL
QANSQGFTPP GMDRSSPDNS PVHGMLRQPS ITTGVNIPII TELVNDTNVQ FLDQDDDDDP
DTELYLTQPF ACGTAFAVSV LDSLMSATYF NDNILTLIRT LVTGGATPEL EALIAEENAL
RGGYSTPQTL ANRDRCRVAQ LALLDGPFAD LGDGGCYGDL FCKALKTYNM LCFGIYRLRD
AHLSTPSQCT KRYVITNPPY EFELVPTDLI FCLMQFDHNA GQSRASLSHS SHSSQSSSKK
SSSVHSIPST ANRQNRPKSR ESRDKQKYVQ EERL
//
