ID U3ESQ6_MICFL Unreviewed; 657 AA.
AC U3ESQ6;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Katanin p80 WD40 repeat-containing subunit B1 {ECO:0000256|HAMAP-Rule:MF_03022};
DE Short=Katanin p80 subunit B1 {ECO:0000256|HAMAP-Rule:MF_03022};
DE AltName: Full=p80 katanin {ECO:0000256|HAMAP-Rule:MF_03022};
GN Name=KATNB1 {ECO:0000256|HAMAP-Rule:MF_03022};
OS Micrurus fulvius (Eastern coral snake) (Coluber fulvius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX NCBI_TaxID=8637 {ECO:0000313|EMBL:JAB54043.1};
RN [1] {ECO:0000313|EMBL:JAB54043.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Venom gland {ECO:0000313|EMBL:JAB54043.1};
RX PubMed=23915248; DOI=10.1186/1471-2164-14-531;
RA Margres M.J., Aronow K., Loyacano J., Rokyta D.R.;
RT "The venom-gland transcriptome of the eastern coral snake (Micrurus
RT fulvius) reveals high venom complexity in the intragenomic evolution of
RT venoms.";
RL BMC Genomics 14:531-531(2013).
CC -!- FUNCTION: Participates in a complex which severs microtubules in an
CC ATP-dependent manner. May act to target the enzymatic subunit of this
CC complex to sites of action such as the centrosome. Microtubule severing
CC may promote rapid reorganization of cellular microtubule arrays and the
CC release of microtubules from the centrosome following nucleation.
CC {ECO:0000256|HAMAP-Rule:MF_03022}.
CC -!- SUBUNIT: Interacts with KATNA1. This interaction enhances the
CC microtubule binding and severing activity of KATNA1 and also targets
CC this activity to the centrosome. {ECO:0000256|HAMAP-Rule:MF_03022}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03022}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000256|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle
CC pole {ECO:0000256|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton
CC {ECO:0000256|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|HAMAP-Rule:MF_03022}. Note=Predominantly cytoplasmic.
CC Localized to the interphase centrosome and mitotic spindle poles.
CC {ECO:0000256|HAMAP-Rule:MF_03022}.
CC -!- SIMILARITY: Belongs to the WD repeat KATNB1 family. {ECO:0000256|HAMAP-
CC Rule:MF_03022}.
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DR EMBL; GAEP01000778; JAB54043.1; -; mRNA.
DR AlphaFoldDB; U3ESQ6; -.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008352; C:katanin complex; IEA:InterPro.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051013; P:microtubule severing; IEA:UniProtKB-UniRule.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR HAMAP; MF_03022; Katanin_p80_B1; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR028021; Katanin_C-terminal.
DR InterPro; IPR026962; KTNB1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19845; KATANIN P80 SUBUNIT; 1.
DR PANTHER; PTHR19845:SF0; KATANIN P80 WD40 REPEAT-CONTAINING SUBUNIT B1; 1.
DR Pfam; PF13925; Katanin_con80; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_03022};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_03022};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03022};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212, ECO:0000256|HAMAP-
KW Rule:MF_03022}; Microtubule {ECO:0000256|HAMAP-Rule:MF_03022};
KW Mitosis {ECO:0000256|HAMAP-Rule:MF_03022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 16..58
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 59..100
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 101..142
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 143..184
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 185..226
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 495..653
FT /note="Katanin p80 subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13925"
FT REGION 316..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 72165 MW; BB1E763AF628DFE0 CRC64;
MAGAVATKTA WKLQEIIAHS SNVSSLVLGK SSGRLLATGG DDCRVNIWSV NKPNCIMSLT
GHTTPVESVK INTNEELIVA GSQSGSIRIW DLEAAKILRT LMGHKANICS LDFHPYGGFV
ASGSMDTNIK LWDVRKKSCV FRYKGHSGAV RCLRFSPDGK WLASSSDDHT VKLWDLAAGK
IMFEFTGHTG PVNVIEFHPN EYLLASGSSD RTVRFWDLEK FQTVSCIEEE ATPVRCVLFN
PDGCCLYAGS QDALRVYGWE PERCFEVVLV NWGKVADLSI CNNQLIGVSF TQSTVSSYVV
DLSRITKCGS GLHGLIRDDK PLSPPPSLGS SLRRIYERPT TTCSKPQRVK HNSESERRSP
SSEDDKEERE STAEIQNLED YKEIFQPKNS ITRTPPSNSE PFPAPPEDEA APAKEASRAG
QAADAASPLP GQERAEPVQR QPIAASTPIT RVEPSVIPAA RNEPIGLKAS DFLPAVKNQG
LAEVADEEAM SQIRKGHETM CVVLTSRHKN LDTVRAVWST GDIKTSVDSA VAINDLSVVV
DLLNIVNQKP SLWKLDLCTV VLPQIEKLLQ SKYESYVQTG CASLKLILQR FLPLITDILA
APPSVGVDIS REERLQKCHM CYKQLKTINA FIKNRSGLSG RHGSAFRELH LLMAVLE
//
