ID U3EVJ2_CALJA Unreviewed; 977 AA.
AC U3EVJ2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=NACHT, LRR and PYD domains-containing protein 3 {ECO:0000256|ARBA:ARBA00040040};
GN Name=NLRP3 {ECO:0000313|EMBL:JAB25900.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB25900.1};
RN [1] {ECO:0000313|EMBL:JAB25900.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebral cortex {ECO:0000313|EMBL:JAB25900.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center {ECO:0000256|ARBA:ARBA00004267}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004394}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; GAMR01008032; JAB25900.1; -; mRNA.
DR RefSeq; XP_017822139.1; XM_017966650.1.
DR AlphaFoldDB; U3EVJ2; -.
DR OrthoDB; 55870at2759; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd00116; LRR_RI; 1.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF19; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 3; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF13516; LRR_6; 4.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 7.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..93
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 218..534
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 977 AA; 111621 MW; 85D997FD2B2CC569 CRC64;
MKMASTRCKL ARYLEDLEDV DFKKFKMHLE DYPPQKGCIP LPRGQTEKAD HVDLATLMID
FNGEEKAWAM AVWIFAAINR RDLYEKAKRD EPKWDNACAS NHTVICQQDS IEEEWMGLLG
YLSRISICKK KKDYGKKYRR HVRSRFQCIE DRNARLGESV SLNKRYTPLR LIKEHRSQQE
REQELLTIGR TKAGDSPVSP IKMESLFEPD AEHAEPVHTV VFQGAAGIGK TILARKIMLD
WASGTLYQDR FDYLFYIHCR ELSLVTQRSL GDLIMSCCPD PNPPIHRIVR KPSRILFLMD
GFDELQGAFD EHIGPLCTDW RKAERGDILL SSLIRKKLLP EAFLLITTRP VALEKLQHLL
DHPRHVEILG FSETKRKEYF FKYFSDEAQA RAAFSLIQEN EVLFTMCFIP LVCWIVCTGL
KQQMESGKSL AQTSKTTTAV YIFFLSSLLQ PRGGSQEHTL SAHLWGLCSL AADGIWNQKI
LFEESDLRNH GLQKAEVSAF LRMNLFQKEV DCEKLYSFIH MTFQEFFAAM YYLLEEEKEG
GMQNVPGSCL TLPSRDVTVL LENYGKFEKG YLIFVVRFLF GLVNQERTSY LEKKLSCKVS
QQIRLELLKW IEVKAKAKKL QIQPSQLELF YCLYEMQEED FVQRAMDHFP KIEINLSTRM
DHVVSSFCIE NCHRVESLSL GFLHNMPKEE EEEEKEGRHL DVAQCVPPGS LTACSLGLVN
SHFTSSFCRG LFSVLSTNQS LTELDLSDNS LGDPGMRVLC ETLQHPGCNI RRLWLGRCGL
SHECCLDLSL VLSSSQKLVE LDLSDNALGD FGIRLLCVGL KHLLCNLKKL WLVNSGLTSA
CCSALSSVLS TNGNLTHLYL RGNTLGDKGI KLLCEGLLHP DCKLQVLELD SCSLTSHCCW
DLSTLLTSSR SLRKLSLGNN DLGDLGVMMF CEVLRQQSCL LQNLGLCEMF FNYETKRALE
TLQEEKPELT IVFEPSW
//
