ID U3EZ16_CALJA Unreviewed; 722 AA.
AC U3EZ16;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=E3 ubiquitin-protein ligase LRSAM1 isoform 1 {ECO:0000313|EMBL:JAB50117.1};
DE SubName: Full=Leucine rich repeat and sterile alpha motif containing 1 {ECO:0000313|Ensembl:ENSCJAP00000065081.1};
GN Name=LRSAM1 {ECO:0000313|EMBL:JAB50117.1,
GN ECO:0000313|Ensembl:ENSCJAP00000065081.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB50117.1};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000065081.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB50117.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB02565.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB50117.1}, Cerebral cortex
RC {ECO:0000313|EMBL:JAB30037.1}, Hippocampus
RC {ECO:0000313|EMBL:JAB21991.1}, and Skeletal muscle
RC {ECO:0000313|EMBL:JAB37782.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000065081.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; GAMT01009296; JAB02565.1; -; mRNA.
DR EMBL; GAMS01001145; JAB21991.1; -; mRNA.
DR EMBL; GAMR01003895; JAB30037.1; -; mRNA.
DR EMBL; GAMQ01004069; JAB37782.1; -; mRNA.
DR EMBL; GAMP01002638; JAB50117.1; -; mRNA.
DR STRING; 9483.ENSCJAP00000065081; -.
DR Ensembl; ENSCJAT00000078420.3; ENSCJAP00000065081.1; ENSCJAG00000018088.5.
DR GeneTree; ENSGT00930000151044; -.
DR OMA; DFWLLQY; -.
DR OrthoDB; 1043058at2759; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000018088; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0045806; P:negative regulation of endocytosis; IEA:Ensembl.
DR GO; GO:2000786; P:positive regulation of autophagosome assembly; IEA:Ensembl.
DR GO; GO:1904417; P:positive regulation of xenophagy; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR GO; GO:0070086; P:ubiquitin-dependent endocytosis; IEA:Ensembl.
DR GO; GO:0046755; P:viral budding; IEA:Ensembl.
DR CDD; cd16515; RING-HC_LRSAM1; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF46; LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 577..631
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 674..709
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 225..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 306..375
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 510..545
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 722 AA; 83524 MW; 18F7D8D9DAEBBD73 CRC64;
MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LSEIPFGAFA TCKVLQKKVL
IVHTNHLTSL LPKSCSLLSL ATIKVLDLHD NQLTALPDDL GQLTALQVLN VERNQLTQLP
HSIGNLTQLQ TLNVKDNKLK ELPDTLGELR SLRTLNISGN EIQRLPQMLA HVRTLEMLSL
DASTMVYPPP EVCSAGTAAI LQFLCKESGL EYYPPSQYLL PVLEQDGTNS RDSPDGPTDR
VSREEVEWQN RFSDYEKRKE QKMLEKLEFE RRLELGQREH AQLLQQSSSQ KDEILQTVKE
EQFRLEQGLS ERQRHLDAER QRLQEQLKQT ERNISSRIQK LLQENQRQKK SSEILKSLEN
ERIRMEQLMS ITQEETENLR RREVASAMQQ MLTERCKNRL MQMAYESQRQ NLAQQACSSM
AEMDERFQQI LSWQQMDQNK AISQILQESA MQKAAFEALQ VKKDLMHRQI RSQIKLIETE
LLQLTQLELK RKSLDTETLQ EMVSEQRWAL SNLLQQLLKE KQQREEELRE ILTELEAKSE
TRQENYWLIQ YQRLLNQKPL SLKLQEEGME SQLVALLEEL SAEHYLPIFA HHRLSLALLS
QMNPGDLAKL GVSEAGLQHE ILRKVQELLD AARIQPELKP PVGEFLTPTA PQEPPESMRP
SAPPAELEVQ ASECVVCLEQ EAQMIFLNCG HVCCCQQCCQ PLRTCPLCRQ DIVQRLRIYH
SS
//
