ID U3FCE7_MICFL Unreviewed; 493 AA.
AC U3FCE7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 22-FEB-2023, entry version 32.
DE SubName: Full=Iroquois protein 2 {ECO:0000313|EMBL:JAB54054.1};
OS Micrurus fulvius (Eastern coral snake) (Coluber fulvius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX NCBI_TaxID=8637 {ECO:0000313|EMBL:JAB54054.1};
RN [1] {ECO:0000313|EMBL:JAB54054.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Venom gland {ECO:0000313|EMBL:JAB54054.1};
RX PubMed=23915248; DOI=10.1186/1471-2164-14-531;
RA Margres M.J., Aronow K., Loyacano J., Rokyta D.R.;
RT "The venom-gland transcriptome of the eastern coral snake (Micrurus
RT fulvius) reveals high venom complexity in the intragenomic evolution of
RT venoms.";
RL BMC Genomics 14:531-531(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC {ECO:0000256|ARBA:ARBA00008446}.
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DR EMBL; GAEP01000767; JAB54054.1; -; mRNA.
DR AlphaFoldDB; U3FCE7; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR PANTHER; PTHR11211:SF15; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-2; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 110..173
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 112..174
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 175..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..283
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..387
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 52370 MW; 85A9AD5217658FE3 CRC64;
MSYPQGYLYQ PPGSLALYSC PAYGASALAA PRSEELARSS SGSAFSPYPG SAAFTAQAAA
TGFSSPLQYS TDPATGFPSY MGSPYDAHTT GMSGAISYHP YGSPAYPYQL NDPAYRKNAT
RDATATLKAW LQEHRKNPYP TKGEKIMLAI ITKMTLTQVS TWFANARRRL KKENKMTWAP
RNKSEDEDED LEGGESGGMR SKEETGSDKG RDSNETSAED EGISLQVDSL TDHSCSAESD
GEKGPCRARE PLSGSECKGD KYEEIEEDDD DEEDEDEDEE DDEAGRGLPA KPVTSSPLTG
VEAPLLGHPH GQDAARNAAK AALDARISPS AASQTAQASK PKLWSLAEIA TSDLKHPPSH
PHGHGHGLGQ SCPPSGPPPP PSAPHNAAYS PPSLLGRHLY YTSPFYGNYT NYGNFNALQG
QGILRYNSAA VASHEGLNQA VLSGGGGGAA LKAGSENSLK AIASHLEQHY KPPSSEGKKD
PTEICTVGVQ PYL
//
