ID   U3FKL8_CALJA            Unreviewed;      1318 AA.
AC   U3FKL8;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   22-FEB-2023, entry version 47.
DE   RecName: Full=Clustered mitochondria protein homolog {ECO:0000256|HAMAP-Rule:MF_03013};
GN   Name=CLUH {ECO:0000313|EMBL:JAB40495.1};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB40495.1};
RN   [1] {ECO:0000313|EMBL:JAB40495.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAB40495.1};
RX   PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA   Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA   Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT   "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT   sequences.";
RL   Gigascience 3:14-14(2014).
CC   -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC       distribution of mitochondria. Specifically binds mRNAs of nuclear-
CC       encoded mitochondrial proteins in the cytoplasm and regulates transport
CC       or translation of these transcripts close to mitochondria, playing a
CC       role in mitochondrial biogenesis. {ECO:0000256|HAMAP-Rule:MF_03013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03013}.
CC       Cytoplasmic granule {ECO:0000256|HAMAP-Rule:MF_03013}.
CC   -!- SIMILARITY: Belongs to the CLU family. {ECO:0000256|HAMAP-
CC       Rule:MF_03013}.
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DR   EMBL; GAMQ01001356; JAB40495.1; -; mRNA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR   CDD; cd15466; CLU-central; 1.
DR   Gene3D; 3.30.2280.10; Hypothetical protein (hspc210); 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   HAMAP; MF_03013; CLU; 1.
DR   InterPro; IPR033646; CLU-central.
DR   InterPro; IPR025697; CLU_dom.
DR   InterPro; IPR028275; CLU_N.
DR   InterPro; IPR027523; CLU_prot.
DR   InterPro; IPR023231; GSKIP_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12601:SF6; CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG; 1.
DR   PANTHER; PTHR12601; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3; 1.
DR   Pfam; PF13236; CLU; 1.
DR   Pfam; PF15044; CLU_N; 1.
DR   Pfam; PF12807; eIF3_p135; 1.
DR   Pfam; PF13424; TPR_12; 2.
DR   SUPFAM; SSF103107; Hypothetical protein c14orf129, hspc210; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS51823; CLU; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03013};
KW   RNA-binding {ECO:0000256|HAMAP-Rule:MF_03013}.
FT   DOMAIN          339..581
FT                   /note="Clu"
FT                   /evidence="ECO:0000259|PROSITE:PS51823"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          640..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1269..1318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1269..1287
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1318 AA;  148157 MW;  78432681AE4B2BA0 CRC64;
     MLLNGDCPES LEKEGVAEPP RENGLEEAEP GDETTGQEVI VIQDTGFSVK ILVPGIEPFS
     LQVSPQEMVQ EIHQVLMDRE DTCHRTCFSL HLDGNMLDHF SELRSVEGLQ EGSVLRVVEE
     PYTVREARIH VRHVRDLLKS LDPSDAFNGV DCNSLSFLSV FTDGDLGALG PSDSGKRKKG
     LEMDPIDCTP PEYILPGSRE RPLCPLQPQN RDWKPLQCLK VLTMSGWNPP PGNRKMHGDL
     MYLFVITAED RQVSITASTR GFYLNQSTAY HFNPKPASPR FLSHSLVELL NQISPTFKKN
     FAVLQKKRVQ RHPFERIATP FQVYSWTAPQ AEHAMDCVRA EDAYTSRLGY EEHIPGQTRD
     WNEELQTTRE LPRKNLPERL LRERAIFKVH SDFTAAATRG AMAVIDGNVM AINPSEETKM
     QMFIWNNIFF SLGFDVRDHY KDFGGDVAAY VAPTNDLNGV RTYNVVDVEG LYTLGTVVVD
     YRGYRVTAQS IIPGILERDQ EQSVIYGSID FGKTVVSHPR YLELLERTSR PLKILRHRVL
     NDRDEEVELC SSVECKGIIG NDGRHYILDL LRTFPPDLNF LPVPGEELPE ECTRAGFPRT
     HRHKLCCLRQ ELVDAFVEHR YLLFMKLAAL QLMQQKASQL QTPSSLENGG PSSMESKPED
     PPRMEAGSEE EGSSASGLAK VKELAETIAA DDGTADPRSR EVIRNACKAV GSISSTAFDI
     RFNPDIFSPG VRFPESCQDE VRDQKQLLKD AAAFLLSCQI PGLVKDCTEH AVLPMDGATL
     AEVMRQRGIN MRYLGKVLEL VLRSPARQQL DHIYKIGIGE LITRSAKHIF KTYLQGVELS
     GLSAAISHFL NCFLSSYPNP VAHLPADELV SKKRSKRRKN RPPGASDNTA WAVMTPQELW
     RNICQEAKNY FDFSLECETV DQAVETYGLQ KITLLREISL KTGIQVLLKE YSFDSRHKPT
     FTEEDVLNIF PVVKHVNPKA SDAFHFFQSG QAKVQQGFLK EGCELINEAL NLFNNVYGAM
     HVETCACLRL LARLHYIMGD YAEALSNQQK AVLMSERVMG IEHPNTIQEY MHLALYCFAS
     SQLSTSLSLL YRARYLMLLV FGEDHPEMAL LDNNIGLVLH GVMEYDLSLR FLENALAVST
     KYHGPKALKV ALSHHLVARV YESKAEFRSA LQHEKEGYTI YKTQLGEDHE KTKESSEYLK
     CLTQQAVALQ RTMNEIYRNG SSANIPPLKF TAPSLASVLE QLNVINGILF IPLSQKDLEN
     LKAEVARRHQ LQEASRNRDK AEEPMATEPE PEPEPSGGPE DLGSEPQAAK DPSPSVQG
//