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Database: UniProt
Entry: U3FWE5_MICFL
LinkDB: U3FWE5_MICFL
Original site: U3FWE5_MICFL 
ID   U3FWE5_MICFL            Unreviewed;       723 AA.
AC   U3FWE5;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   22-FEB-2023, entry version 31.
DE   RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha {ECO:0000256|ARBA:ARBA00013911};
DE   AltName: Full=Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha {ECO:0000256|ARBA:ARBA00031433};
OS   Micrurus fulvius (Eastern coral snake) (Coluber fulvius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX   NCBI_TaxID=8637 {ECO:0000313|EMBL:JAB53701.1};
RN   [1] {ECO:0000313|EMBL:JAB53701.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Venom gland {ECO:0000313|EMBL:JAB53701.1};
RX   PubMed=23915248; DOI=10.1186/1471-2164-14-531;
RA   Margres M.J., Aronow K., Loyacano J., Rokyta D.R.;
RT   "The venom-gland transcriptome of the eastern coral snake (Micrurus
RT   fulvius) reveals high venom complexity in the intragenomic evolution of
RT   venoms.";
RL   BMC Genomics 14:531-531(2013).
CC   -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC       {ECO:0000256|ARBA:ARBA00009442}.
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DR   EMBL; GAEP01001120; JAB53701.1; -; mRNA.
DR   AlphaFoldDB; U3FWE5; -.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd12924; iSH2_PIK3R1; 1.
DR   CDD; cd04388; RhoGAP_p85; 1.
DR   CDD; cd09930; SH2_cSH2_p85_like; 1.
DR   CDD; cd09942; SH2_nSH2_p85_like; 1.
DR   CDD; cd11910; SH3_PI3K_p85alpha; 1.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 2.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR044124; ISH2_PIK3R1.
DR   InterPro; IPR032498; PI3K_P85_iSH2.
DR   InterPro; IPR035591; PI3K_p85alpha_SH3.
DR   InterPro; IPR035020; PI3kinase_P85_cSH2.
DR   InterPro; IPR035022; PI3kinase_P85_nSH2.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR   Pfam; PF16454; PI3K_P85_iSH2; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00017; SH2; 2.
DR   PRINTS; PR00678; PI3KINASEP85.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00252; SH2; 2.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF55550; SH2 domain; 2.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50001; SH2; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:JAB53701.1};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:JAB53701.1}.
FT   DOMAIN          3..79
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          113..300
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          332..427
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          623..717
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   COILED          513..561
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   723 AA;  83616 MW;  8337F0FA4007AAE3 CRC64;
     MSAEGYQYKA LYDYKKEREE DIDLRLGDIL TVNKGTLVAL GFSDGEEGKP EEIGWLNGYN
     EMTGERGDFP GTYVEYIGRK KISPPTPKPR PVRPLPMAPS PARVGTETDQ PVFTLSDLCE
     QFSPPENAPP LLMKLVEAIE RKGLECSSLY KSQGSSSSVE LRQIIECEVS SVDFEGIELH
     ILTDALKRYF LDLPNPVIPA SVYNEMISVA QEVQNSKEYA QALKRLIRSP NIPQQYWLTL
     QYLLKHLSRL CQVSTKNSLN AKSLAEIFSL LLFRSPVASS DSEQHIKILE VLITSELNER
     QPAPALPPKP PKPNTVTNNG MNNNMSLQDA EWYWGDISRE EVNEKLRDTA DGTFLVRDAS
     TKMHGDYTLT LRKGGNNKLI KIFHRDGKYG FSDPLTFNSV VELINHYRNE SLAQYNPKLD
     VKLLYPVSKY QQDQVVKEDS IEAVGKKLHE YNIQFQEKNR EYDRLYEDYT RTSQEIQMKR
     TAIEAFNETI KIFEEQCQTQ ERYSKEYIEK FKREGNEKEI QRIMHNYEKL KSRISEIVDS
     RHRLEEDLKK QAAEYREIDK RMNSIKPDLI QLRKTRDQYL MWLTQKGVRQ KKLNEWLGNE
     NSEDQYSIVE DDEDLPHHDE RSWNVGNINR SQAENLLRGK RDGTFLVRES SKQGCYACSV
     VVDSEVKHCV INKTPTGYGF AEPYNLYNTL KELVLHYQHT SLVQHNDSLN VTLAYPVYAQ
     QRR
//
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