ID U3FYS1_MICFL Unreviewed; 847 AA.
AC U3FYS1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS Micrurus fulvius (Eastern coral snake) (Coluber fulvius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX NCBI_TaxID=8637 {ECO:0000313|EMBL:JAB52925.1};
RN [1] {ECO:0000313|EMBL:JAB52925.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Venom gland {ECO:0000313|EMBL:JAB52925.1};
RX PubMed=23915248; DOI=10.1186/1471-2164-14-531;
RA Margres M.J., Aronow K., Loyacano J., Rokyta D.R.;
RT "The venom-gland transcriptome of the eastern coral snake (Micrurus
RT fulvius) reveals high venom complexity in the intragenomic evolution of
RT venoms.";
RL BMC Genomics 14:531-531(2013).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; GAEP01001896; JAB52925.1; -; mRNA.
DR AlphaFoldDB; U3FYS1; -.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF22; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 410..435
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 456..473
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 547..565
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 577..600
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 640..659
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 776..800
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 94..128
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 847 AA; 96992 MW; 541E647069009311 CRC64;
MGSLFRSEAM CLAQLFLQAG SAYECLSALG ERGLAHFRDL NSNTSLFQRK YVGEVKKCEE
MERILGYLVQ EIKKSDIPLP EGNITPSAPP LKQMLEIQEQ LQKLEVELRE VTKNKEKLRK
NLLELTEYTH LLKVTQSFIQ RSTELESCIQ SAYEELPSFD LDPLVEYNCL HRLEAKLGFI
SGLVHRAKVE AFEKMLWRVC RGNTIVSYSE VEECLEDPDT GELTKCFVFL ISYWGEQIGQ
KVKKICDCYH CHLYPYPSTP AERQAVMEGL QVRIQDLHIV LHKTEDYLRQ VLCKASESIY
TWDVQVKKMK AIYHVLNLCS FDVTNKCLIA EVWCPLADLP NMRRTLEESS RRSGASVPSF
MNTIPTKETP PTLIRTNKFT SGFQDIVDVY GIGNYREVNP ALFTIVTFPF LFAVMFGDCG
HGFLMFLFAL VMVLFEKHPK LRRSQDEIMK MIFQGRYIIM LMGLFSIYTG LIYNDCFSKS
LVIFSSGWHV SQMPGMDWSK ADLTNPLVAL NPNATGVFTG PYPFGIDPIW SLAGNRLSFL
NSFKMKMSVI IGMVHMVFGI ALGGFNYMHF RKMYNIYLVF IPQLLFILSI FGYLVFMIIF
KWLAYSAENS SSAPSILLQF INMFLFHDNK NQVLFSGQMV VQKCLLVVAV LSVLVLFFGK
PLYLYWLNNG SQSFGSYRKG YRLVRKESEE EISLLTTCEM EEGTSPLNNR HKAEDKEEFS
FASALMEQAI QTIEYCLGCI SNTASYLRLW ALSLAHAQLS EVLWAMVMKL GLHMDAAYGI
LLLVPLSALF MVLTVFILLV MEGLSAFLHA VRLHWVEFQN KFYTGDGYKF TPFSFQDISL
HLDRYTA
//
