ID U3FZH8_MICFL Unreviewed; 564 AA.
AC U3FZH8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 28-JUN-2023, entry version 31.
DE SubName: Full=Fragile X mental retardation protein 1 B {ECO:0000313|EMBL:JAB54210.1};
OS Micrurus fulvius (Eastern coral snake) (Coluber fulvius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX NCBI_TaxID=8637 {ECO:0000313|EMBL:JAB54210.1};
RN [1] {ECO:0000313|EMBL:JAB54210.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Venom gland {ECO:0000313|EMBL:JAB54210.1};
RX PubMed=23915248; DOI=10.1186/1471-2164-14-531;
RA Margres M.J., Aronow K., Loyacano J., Rokyta D.R.;
RT "The venom-gland transcriptome of the eastern coral snake (Micrurus
RT fulvius) reveals high venom complexity in the intragenomic evolution of
RT venoms.";
RL BMC Genomics 14:531-531(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cell projection, axon {ECO:0000256|ARBA:ARBA00004489}. Cell projection,
CC dendrite {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic
CC spine {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium tip
CC {ECO:0000256|ARBA:ARBA00004495}. Cell projection, growth cone
CC {ECO:0000256|ARBA:ARBA00004624}. Cell projection, neuron projection
CC {ECO:0000256|ARBA:ARBA00004487}. Chromosome, centromere
CC {ECO:0000256|ARBA:ARBA00004584}. Cytoplasm, Cytoplasmic
CC ribonucleoprotein granule {ECO:0000256|ARBA:ARBA00004331}. Cytoplasm,
CC Stress granule {ECO:0000256|ARBA:ARBA00004210}. Cytoplasm, perinuclear
CC region {ECO:0000256|ARBA:ARBA00004556}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}. Presynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034111}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034109}.
CC -!- SIMILARITY: Belongs to the FMR1 family.
CC {ECO:0000256|ARBA:ARBA00006633}.
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DR EMBL; GAEP01000611; JAB54210.1; -; mRNA.
DR AlphaFoldDB; U3FZH8; -.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0032433; C:filopodium tip; IEA:UniProtKB-SubCell.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd22506; KH_I_FMR1_rpt1; 1.
DR CDD; cd22509; KH_I_FMR1_rpt2; 1.
DR CDD; cd22512; KH_I_FMR1_rpt3; 1.
DR CDD; cd20471; Tudor_Agenet_FMR1_rpt1; 1.
DR CDD; cd20474; Tudor_Agenet_FMR1_rpt2; 1.
DR Gene3D; 2.30.30.140; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR040148; FMR1.
DR InterPro; IPR022034; FMR1-like_C_core.
DR InterPro; IPR032196; FMR1_C2.
DR InterPro; IPR040472; FMRP_KH0.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047438; KH_I_FMR1_rpt1.
DR InterPro; IPR047440; KH_I_FMR1_rpt2.
DR InterPro; IPR047431; Tudor_Agenet_FMR1_rpt1.
DR InterPro; IPR047436; Tudor_Agenet_FMR1_rpt2.
DR InterPro; IPR041560; Tudor_FRM1.
DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR PANTHER; PTHR10603:SF4; SYNAPTIC FUNCTIONAL REGULATOR FMR1; 1.
DR Pfam; PF05641; Agenet; 1.
DR Pfam; PF16098; FXMR_C2; 1.
DR Pfam; PF12235; FXMRP1_C_core; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF17904; KH_9; 1.
DR Pfam; PF18336; Tudor_FRX1; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR PROSITE; PS51641; AGENET_LIKE; 2.
DR PROSITE; PS50084; KH_TYPE_1; 2.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 4..50
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT DOMAIN 63..115
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT REGION 377..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 63753 MW; E8D53F30CB6F5F9D CRC64;
MEELVVEVRG SNGAFYKAFV KDVHEDSITV AFENNWQPER QIPFHDVRFP PPTGYNKDIN
ESDEVEVYSR ANEKEPCCWW LAKVRMIKGE FYVIEYAACD ATYNEIVTIE RLRSVNPNKP
ATKDTFHKIK LDVPEDLRQM CAKESAHKDF KKAVGAFSVT YDPEAHQLII LSVNEVTTKR
ANMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH EQFVVREDLM GLAIGTHGAN
IQQARKVPGV TAIDLDEDTC TFHIYGEDQD AVKKARSYLE FAEDVIQVPR NLVGKVIGKN
GKLIQEIVDK SGVVRVRIEA ENDKNIPQEE GMVPFVFVGT KDSITNATVL LDYHLNYLKE
VDQLCLERLQ IDEQLRQIGA TSRPPPNRPD KEKVYMSDDG PSLGRGGRPY RNRGHSRRGP
GYASGTNSEA SNASETESDH RDELSDWSLA PAEEERDSYL RRGDGRRRGG GARGQGGRGR
AGFKGNEDQS RTDNRQRKSR DAKGRTDGSL QIRIDCNNER SVHTKTLQNI SSEASRLRTG
KDRNQKKEKS DSGESQQPLV NGVP
//
