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Database: UniProt
Entry: U3IC48_ANAPL
LinkDB: U3IC48_ANAPL
Original site: U3IC48_ANAPL 
ID   U3IC48_ANAPL            Unreviewed;      4872 AA.
AC   U3IC48;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   25-OCT-2017, entry version 30.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSAPLP00000004820};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSAPLP00000004820};
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anas.
OX   NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000004820, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000004820}
RP   NUCLEOTIDE SEQUENCE.
RA   Li N.;
RT   "The genome sequence and transcriptome of duck provide insight into
RT   the interaction host.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000004820}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23749191; DOI=10.1038/ng.2657;
RA   Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H.,
RA   Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q.,
RA   Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A.,
RA   Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J.,
RA   Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G.,
RA   Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M.,
RA   Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J.,
RA   Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J.,
RA   Li N.;
RT   "The duck genome and transcriptome provide insight into an avian
RT   influenza virus reservoir species.";
RL   Nat. Genet. 45:776-783(2013).
RN   [3] {ECO:0000313|Ensembl:ENSAPLP00000004820}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAPLP00000004820}.
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DR   EMBL; ADON01006024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01006025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01006026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01006027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01006028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01006029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01006030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01006031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01006032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAPLT00000005441; ENSAPLP00000004820; ENSAPLG00000005134.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000016666; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 8.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016666};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4185   4209       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4412   4432       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4476   4498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4673   4694       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4753   4776       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    154       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      161    206       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      214    268       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      274    331       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      342    399       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      584    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1207       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1253   1467       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3929   3957       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4872 AA;  553145 MW;  A7261F236A5B1EE3 CRC64;
     MAEGGEGGED EIQFLRTDDE VVLQCVASVH KEQRKFCLAA EGLGNRLCFL EPTSEAKYVP
     PDLCICNFVL EQSLSVRALQ EMLANTGDNA GEGAAQGGHR TLLYGHAILL RHSFSEMYLT
     CLTSSRSQTD KLAFDVGLRE NAAGEACWWT IHPASKQRSE GEKVRIGDDL ILVSVSSERY
     LHLSMSNGSI QVDASFMQTL WNVHPTCSGS SITEGYLLGG HVVRFFHGHD ECLTIPSTDQ
     NDSQQKKVLY ETGGAGVRAR SLWRVEPLRI SWSGSNIKWG QPFRLRHITT GMYLALNDDE
     GLVMLDREKS DTTSSAFCFR ASKELKEKQD STLKRDIDGM GVPEIKYGDS VCFVQHVASA
     LWLTYKAQDA KSARLGPLKR KVILHQEGHM DDGLTLQRCQ HEESQAARII RNTTSLFSQF
     ISGNNRTLSP IALPVEEMAQ TLQDLITYFQ PPEEDLEHED KQSKLRSLKN RQNLFKEEGM
     LALVLNCIDR LNDYNSAAHF AEIAREENGT TWKEILNLLY KLLAALIRGN RNNCTQFSSN
     LDWLISKLDR LESSSGILEV LHCILIESPE ALNIIAEEHI KSIISLLDKH GRNYKVLDVL
     CSLCVCNGVA VRANQNLICD NLLPRRDLLL QTRLINDVTS IRPNIFLGVA EGSAQYKKWY
     FELIIDQVDP FLTAEPTHLR VGWASTSGYA PYPGGGEGWG GNGVGDDLYS YGFDGLHLWS
     GRVPRAVASV NQHLLSSDDV VSCCLDLGVP SISFRINGQP VQGMFENFCT EGFFFPVVSL
     SAGVKARFLL GGRHGEFKFL PPAGYAPCYE ALLPKEKMKL EPVKEYKRDS DGVRDLLGTT
     QFLSQASFIP CPIDTSQIAL PFHLEKIRDK LAENIHELWG MNKIELGWTY GKIRDDNKRH
     HPCLVEFSKL PETEKNYNLQ MSTETLKTLL ALGCHIVHAN PAAEEDLKKV KLPKNYMMSN
     GYKPAPLDLS EVKLLPSQEF LVDKLAENAH NVWAKDRIKQ GWTYGIQQDL KNKRNPRLVP
     YALLDERTKK SNRDSLREAV RTFAGYGYSV EPPDQEIADQ TTEKVSIDKI RFFRVEQSYA
     VKSGKWYFEF EAVTGGDMRV GWARPGCRPD IELGADDQAF VFEGSKGQRW HQGSGFFGRS
     WQPGDVVGCM INLDDKSIIF TLNGELLITS KGSELAFADF GIESGFVPIC ALGLSQIGRM
     NLGMDASTFK YYTMCGLQEG FEPFAVNMNR DVAMWFSKRL PTFVNVPKNH PHIEIWRIDG
     TIESPPRLKV THKTFGTQNS NSDMIYCRLS MPIEFRSSFN FGMGVENASS DIFQKRKHSQ
     EISVPSTTYF YSLRIFAGQD PSCVWVGWVT PDYHFYSENF DLNKNCTVTV TLGDERGRVH
     ESVKRSNCYM VWGGDITSNS QRSGRSNVDL EIGCFVDLAT GMLSFTANGK ELGTCYQVEP
     NTKLFPATFV QPTSTNLVQF ELGKLKNTMP LSAAIFKSEE RNPIPQCPPR LDVQTITPVL
     WSRMPNSFLK VETERVSERH GWVVQCLEPL QMMALHIPEE NRCVDILELC EQEDLMKFHY
     HTLKLYSSVC ALGNTRVAYA LCSHVDVSQL FYTIDNQYLP GLLRSGFYDL LISIHLEHAK
     QAKLMMNNEF IIPVTEETRT IRLYPDETKK HGLPGVGLST CLKPSFHFST PCFIVTSEEH
     QTSSPEIPLD TLKSKAISML TEAVQCSGTH IRDPVGGHIT FQFVPVLKLI ATLLIMGVFD
     DDDVKQVLIL IDPNVFGDHK EETEEGTEKE EVTQVEEKAV EAGEKAIKET KAPTTGLLQT
     RLPESVKLQM CHLLNYFCDC ELQHRVEAIV SFADRYVSKL QYNQKYRYNE LMQALNMSAA
     LTAKKTKEFR SPPQEQINML LNFQLGEDCP CPEEIRDELY DFHDDLLIHC GIPLEEEEEE
     EEDSTLTGKL RSLIYKIKGP PKAEKVEPRE EEEKSPTTLK ELISQTMVRW SQEDQIQDPE
     LVRIMYTLLR RQYDSIGELL QALRKAYTIS AVSVKDTINL LAALGQIRSL LSVRMGKEEE
     LLMINGLGDI MNNKVFYQHP NLMRVLGMHE TVMDVMVNVL GGDKSQIAFP KMVASCCRFL
     CYFCRISRQN QKAMFEHLSY LLENSSVGLA FPSMRGSTPL DVAAASVMDN NELALALEEP
     DLDKVSVVTY LAGCGLQSCP VLLAKGYPDI GWNPIEGERY LSFLRFAVFV NSESVEENAS
     VVVKLLIRRP ECFGPDLRGE GGNGLLAAMQ EAIRISENPS RDLPSQGYKR EGDEEEEEEE
     IVHMGNAIMS FYSALIDLLG RCAPEMHLIQ SGKGEAIRIR SILRSLVPTE DLVGIISIPL
     KLSTVNKDGT VNEPDMSANF CPDHKAPMVL FLDRVYGIKD QTFLLHLLEV GFLPDLRASA
     SLDTVSLSTT EAALALNRYI CSAVFPLLKR CAPLFSGTEH HASLVDSMLH TIYRLSKGRS
     LTKAQRDTIE ECLLAICHHL RPSMLQQLLR RLVFDVPLLN EYCKMPLKLL TNHYEQCWKY
     YCLPSGMGSY GIAAEEELHL TEKLFWGIFD SLSHKKYDPE LFRMALPCLS AIAGALPPDY
     LDTRIRSTLE KQTSVDPEGN FDPKPVSTAN LVLPEKLEYI VSKYAEHSHD KWAFDKTNNG
     WKYGVSLDEN TKTHPLIRPF KTLTEKEKEI YRWPARESLK TMLAMGWSLE RTKEGGETIL
     HQRENEKLRS ISQSSQGNGY SPAPLDLSNV VLSRELQGMV EVMAENYHNI WAKKKKMELE
     SKGGGSHPLL VPYDTLTAKE KSRDREKAQE LFKFLQVNGI IISRGLNDMD LDASSMEKRF
     AFKFLKKILK YVDSAQEFIA HLEAIVTSGK TEKSPHDQEI NILQMVLLPL VDQYFTNHCL
     YFLSSPTKTL SSSGYASNKE KEMVASLFCK LAALVRHRIS IFGSDSTTMV NCLHILAQSL
     DTRTVMKSGS ELVKAGLRAF FENAAEDLEK TSENLKLGKF THSRTQIKGV SQNINYTTVA
     LLPVLTSIFE HISQYQFGDF VMGDVQVSCY RILCSLYSLG TGKNIYVERQ RPALGECLAS
     LAAAIPVAFL EPSLNHYNPL SVFNTKSARE RAILGMPDTV EEMCPEIPQL DGLIKEINDL
     AESGARYTEM PHVIEVILPM LCNYLSYWWE RGSESVPESA GPFCTMITSE HLSIILGNIL
     KIINNNLGID EASWMKRIAV YAQPIISKAR PDLLKTHFIP TLEKLKKKAI KIVMEEEQLK
     ADSKTDTQEA ELLILDEFAV LCRDLYAFYP MLIRYVDNNR ANWLKKPDAD SDELFRMVAE
     VFILWCKSHN FKREEQNFVI QNEINNLAFL TGDTKSKMSK IFLLQSGGQD QERKKSKRRG
     DLYSIQTSLI VAALKKMLPI GLNMCTPGDQ ELISLAKTRY SHRDTDEEVK EHLRNNLHLQ
     EKSDDPAVKW QLNLYKDILK NDEPSDPEKN VERVQRISAA LYHLEQVEQP LRSKKAVWHK
     LLSKQRKRAV VACFRMAPLY NLPRHRSINL FLHGYQNYWI ETEEYSFEEK LVQDLATPPK
     KDEEEEEDTE KKQPDPLHQI ILYFSRNALT ERSKLEDDPL YIAYSAMMAK VNTEFQSVIC
     SHFCSQTQEK EMEKQRTLYQ QARLHDRGAA EMVLQMISAS KGHTGPMVVE TLKLGIAILN
     GGNTIVQQKM LDYLKEKKDA GFFQSLSGLM QSCSVLDLNA FERQNKAEGL GMVTEEGTLI
     VRERGEKVLQ HDEFTRDLFR FLQLLCEGHN NDFQNYLRTQ MGNTTTVNII ISTVDYLLRL
     QESISDFYWY YSGKDVIDES GQRNFSKALA VTKQIFNSLT EYIQGPCIGN QQSLAHSRLW
     DAVVGFLHVF ANMQMKLSQD SAQIELLKEL LDLLKDMVVM LLSLLEGNVV NGTIGKQMVD
     TLVESSSNVE LILKFFDMFL KLKDLTNSDA FKEHDPDGKG IISKKEFQKS MEAQKQYIQS
     EIEFLLSCAE ADENDMFNYL DFVERFHEPA KDIGFNVAVL LTNLSEHMPN DSRLQSLLEP
     AESVLNYFEP YLGRIEIMGG AKKIERVYFE ISESSRMQWE KPQVKESKRQ FIFDVVNEGG
     EQEKMELFVN FCEDTIFEMQ LASQISETDS AERPEEEEEE ESCYVVDIGD DEEEEKSLES
     PSAFAMACAA VKKNVTNFFK MVTVKNLRKQ YRKVRKMTVK EMVKVFFSFF WILFVGMFQL
     FFTIVWGIFQ ILWSTVFGGG LVEGAKNIKV TKILGDMPDP TQFGIHDDVT EAEKAEGAEH
     GIRAELVQFV KGEKAETDII SDIFGIPTKK EGGSKHGHDA GLGDIAEMLG SDIQSSLENT
     VRKKKGLQLS EIAKEAEAER KVEAEKADME DGEKEDKAKE VQSEQLEEGK VKKKKRRHGQ
     KIEKPEAVMA NFFKALEIYQ TKMLHYLARN FYNLRFLALF VAFAINFILL FYKVTEEPLD
     EVEEDSNLWN TFDEEEEEEG MVFFVLEEST GYMAPALRAL AVIHTIISFV CVIGYYCLKA
     KVPLVVFKRE KEVARKLEFD GLYITEQPSE DDIKGQWDRL VINTPSFPNN YWDKFVKRKV
     INKYGDLYGA ERIAELLGLD KNALDFSPVE ESEPEEASLL SWLSSIDTKY HIWKLGVVFT
     DNSFLYLAWY TTMSILGHYN NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK QLVLTVGLLA
     VVVYLYTVVA FNFFRKFYNK SEDEDEPDMK CDDMMTCYLF HMYVGVRAGG GIGDEIEDPA
     GDPYEMYRIV FDITFFFFVI VILLAIIQGL IIDAFGELRD QQEQVREDME TKCFICGIGN
     DYFDTTPHGF ETHTLQEHNL ANYLFFLMYL INKDETEHTG QESFVWKMYQ ERCWDFFPAG
     DCFRKQYEDQ LG
//
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