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Database: UniProt
Entry: U3IFQ1_ANAPL
LinkDB: U3IFQ1_ANAPL
Original site: U3IFQ1_ANAPL 
ID   U3IFQ1_ANAPL            Unreviewed;      2248 AA.
AC   U3IFQ1;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   25-OCT-2017, entry version 30.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1B {ECO:0000313|Ensembl:ENSAPLP00000006073};
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anas.
OX   NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000006073, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000006073}
RP   NUCLEOTIDE SEQUENCE.
RA   Li N.;
RT   "The genome sequence and transcriptome of duck provide insight into
RT   the interaction host.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000006073}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23749191; DOI=10.1038/ng.2657;
RA   Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H.,
RA   Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q.,
RA   Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A.,
RA   Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J.,
RA   Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G.,
RA   Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M.,
RA   Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J.,
RA   Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J.,
RA   Li N.;
RT   "The duck genome and transcriptome provide insight into an avian
RT   influenza virus reservoir species.";
RL   Nat. Genet. 45:776-783(2013).
RN   [3] {ECO:0000313|Ensembl:ENSAPLP00000006073}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAPLP00000006073}.
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DR   EMBL; ADON01124516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01124517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01124518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01124519; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01124520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01124521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01124522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01124523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01124524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01124525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAPLT00000006711; ENSAPLP00000006073; ENSAPLG00000005963.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; DSPRNNA; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000016666; Unassembled WGS sequence.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0048265; P:response to pain; IEA:Ensembl.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016666};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     74     91       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    112    133       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    145    165       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    200    222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    276    297       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    309    331       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    487    507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    513    530       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    612    634       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    690    712       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1157   1176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1196   1217       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1229   1247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1290   1312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1402   1427       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1483   1501       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1513   1539       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1606   1624       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1694   1718       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1856   1890       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      721    748       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2248 AA;  254960 MW;  4E4C27D4211D4D09 CRC64;
     MARFGDDLPT RYGGGGPAGA GRGSSQEGGA HYNPIPVKQN CFTVNRSLFI FSEDNVIRKY
     AKRITEWPYP FSPFEYMILA TIIANCIVLA LEQHLPDGDK TPMSERLDDT EPYFIGIFCF
     EAGIKIIALG FVFHKGSYLR NGWNVMDFVV VLTGILATAG TDFDLRTLRA VRVLRPLKLV
     SGIPSLQVVL KSIMKAMVPL LQIGLLLFFA IVMFAIIGLE FYMGKFHKTC FSNETGDEVG
     DFPCGEEPPA RQCEVGTTCR EYWQGPNYGI TNFDNILFAV LTVFQCITME GWTDILYNTN
     DAAGNTWNWL YFIPLIIIGS FFMLNLVLGV LSGEFAKERE RVENRRAFLK LRRQQQIERE
     LNGYLEWIFK AEEVMLAEED KNAEEKSPLD VSGRAASEGP IQQGTAPAET SSGSSYNMLK
     RAAIKKSKND LIHAEEGEDH FTDICSVGSP FARASLKSGK NESSSYFRRK EKMFRFFIRR
     MVKAQSFYWI VLCVVALNTL CVAMVHYDQP EKLTTALYFA EFVFLGLFLT EMSLKMYGLG
     PRNYFHSSFN CFDFGVIVGS IFEVIWAAVK PGTSFGISVL RALRLLRIFK VTKYWNSLRN
     LVVSLLNSMK SIISLLFLLF LFIVVFALLG MQLFGGQFNF QDETPTTNFD TFPAAILTVF
     QILTGEDWNA VMYHGIESQG GVHSGMFSSI YFIVLTLFGN YTLLNVFLAI AVDNLANAQE
     LTKDEEEMEE ATNQKLALQK AKEVAEVSPM SAANISIAAK QQNSSKSKSV WEQRTSQIRM
     HNFRASCEAL YNELDPEERV RYATTLHIRP DMKTHLDRPL VVEPRGEGRN NISKLSPGDV
     QEVEQSKVSS ADGAEAPRKH HRHRDKDKLG EQEKCDVTKE ENGESGTNSK EERHRQHRSR
     SKEVEGCSKE GKSDRTRGQE GGKRHHRRGS VEEGAEKEHR RHRTHRHSAE RQGKEGNGTI
     NGARGERRSR HRGGSRSGNR EGEPCSKGEN GEEPHRRHRF RNRALSTYDC KALPCRKQSS
     KTYQELQHMF SEPLENQCEI EASGSVSVPV HTLPSTYLQK VPEQPEDADN QKNVTRMIQP
     PLDKTTTVNI PVTITAPPGE TTVIPMNNVE FESKTEEKKD VDDLTKNGPK PILPYSSMFI
     LSPTNPIRRL FHYIVNLRYF EMVILIVIAL SSIALAAEDP VQAESPRNDA LKYLDYIFTG
     VFTFEMVIKM IDLGLLLHPG SYFRDLWNIL DFIVVSGALV AFAFSGTKGK DINTIKSLRV
     LRVLRPLKTI KRLPKLKAVF DCVVNSLKNV LNILIVYMLF MFIFAVIAVQ LFKGRFFYCT
     DESKELEKDC RGQYLDYEKN EVEAQPREWK KYEFHYDNVL WALLTLFTVS TGEGWPTVLK
     HSVDATYEEQ GPSPGYRMEM SIFYVVYFVV FPFFFVNIFV ALIIITFQEQ GDKVMSECSL
     EKNERACIDF AISAKPLTRY MPQNKQSFQY KMWKFVVSPP FEYFIMVMIA LNTIVLMMKF
     YDAPEAYEEM LKCLNIVFTS MFSMECVLKI IAFGVLNYFR DAWNVFDFVT VLGSITDILV
     TEIADTDNFI NLSFLRLFRA ARLIKLLRQG YTIRILLWTF VQSFKALPYV CLLIAMLFFI
     YAIIGMQVFG NIALDDETSI NRHNNFRTFL QALMLLFRSA TGEAWHEIML SCLSNRACDP
     LSGLTKNECG SDFAYFYFVS FIFLCSFLML NLFVAVIMDN FEYLTRDSSI LGPHHLDEFV
     RVWAEYDPAA CCRIHYKDMY NLLRVIAPPL GLGKKCPHRV AYKRLVRMNM PISPEDLTVH
     FTSTLMALIR TALEIKLATG GVKQHQCDAE LRKEISLVWP NLSQKTLDLL VPPHKPDEMT
     VGKVYAALMI FDFYKQNKNS REQVHQPPGG LCQPGPVSLF HPLKATLEQT QPAAFSNAKA
     FLRQKSSASL NNGGTLPPPE GGIKESSSWG TQRTQDVFYE TRTPAFERGH SEEIPIERVV
     EMREISPTLT NGEHQPGLES QGRAASMPRL AAETQRSKAR SPGSYLAPIP DTSPMKRSIS
     TLTPQRPHAM HLYEYSLERM PTDQGRKEKK QKSLDRSPHQ LADGEAVAQH GESSSKDKKH
     ERGRSQERKQ HSSSSSEKQR FYSCDRYGSR DRSQPKSADQ SRPTSPNGGP EQGPHRQGSG
     SVNGSPLLST SGASTPCRGR RQLPQTPLTP RPSITYKTAN SSPVHFTTXT SYVSSLTSQS
     HQARRVPNGY HYTXGRSYYH EADEDDWC
//
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