GenomeNet

Database: UniProt
Entry: U3IGT6_ANAPL
LinkDB: U3IGT6_ANAPL
Original site: U3IGT6_ANAPL 
ID   U3IGT6_ANAPL            Unreviewed;       817 AA.
AC   U3IGT6;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   07-JUN-2017, entry version 22.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A1 {ECO:0000313|Ensembl:ENSAPLP00000006458};
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anas.
OX   NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000006458, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000006458}
RP   NUCLEOTIDE SEQUENCE.
RA   Li N.;
RT   "The genome sequence and transcriptome of duck provide insight into
RT   the interaction host.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000006458}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23749191; DOI=10.1038/ng.2657;
RA   Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H.,
RA   Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q.,
RA   Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A.,
RA   Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J.,
RA   Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G.,
RA   Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M.,
RA   Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J.,
RA   Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J.,
RA   Li N.;
RT   "The duck genome and transcriptome provide insight into an avian
RT   influenza virus reservoir species.";
RL   Nat. Genet. 45:776-783(2013).
RN   [3] {ECO:0000313|Ensembl:ENSAPLP00000006458}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAPLP00000006458}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; ADON01022369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01022370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAPLT00000007104; ENSAPLP00000006458; ENSAPLG00000006725.
DR   GeneTree; ENSGT00390000004941; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000016666; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0016241; P:regulation of macroautophagy; IEA:Ensembl.
DR   GO; GO:1901998; P:toxin transport; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016666};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    410    434       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    473       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    551    572       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    602       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    643    667       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    786    813       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       96    130       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   817 AA;  93499 MW;  F33F71E3563D038C CRC64;
     MGELFRSEEM TLAQLFLQSQ SEAAYCCVSE LGELGKVQFR DLNPDVNVFQ RKFVNEVRRC
     EEMDRKLRFV EKEIKKANIP IMDTGENPEV PFPRDMIDLE ANFEKIENEL KEINTNQEAL
     KRNFLELTEL KFILRKTQQF FDEAELHHQQ MADPDLLEES SSLLEPSEMG RGAPLRLGFV
     AGVINRERIP MFERMLWRVC RGNVFLRQAE IENPLEDPVT GDYVHKSVFI IFFQGDQLKN
     RVKKICEGFR ASLYPCPETP QERKEMASGV NTRIDDLQMV LNQTEDHRQR VLQAAAKNIR
     VWFIKVRKMK AIYHTLNLCN IDVTQKCLIA EVWCPVADLD SIQFALRRGT EHSGSTVPSI
     LNRMQTNQTP PTYNKTNKFT CGFQNIVDAY GIGTYREINP APYTIITFPF LFAVMFGDFG
     HGILMTLIAV WMVFRESRIL SQKSDNEMFN TVFSGRYIIL LMGLFSTYTG LIYNDCFSKS
     LNMFGSSWSV RPMFTKGNWS DALLETTPLL QLNPAIPGVF GGPYPFGIDP IWNIATNKLA
     FLNSFKMKMS VILGIIHMLF GVTLSLLNHI YFKKPLNIYL GFIPEIIFMS SLFGYLVILI
     FYKWTAYDAH TSKDAPSLLI HFINMFLFSY GDTSNKMLYK GQQGLQCFLV VVALLCVPWM
     LVAKPLVLRH QYLRRKHLGT HNFGGIRVGN GPTEEDAEII QHDQLSTHSE EGEEPTEDEV
     FDFADTVVYQ AIHTIEYCLG CISNTASYLR LWALSLAHAQ LSEVLWTMVI HVGLSVRSLG
     GSFGLFFIFA AFATLTVAIL LVMEGLSAFL HALRLHW
//
DBGET integrated database retrieval system