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Database: UniProt
Entry: U3IRD7_ANAPL
LinkDB: U3IRD7_ANAPL
Original site: U3IRD7_ANAPL 
ID   U3IRD7_ANAPL            Unreviewed;      1976 AA.
AC   U3IRD7;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=LOC101799248 {ECO:0000313|Ensembl:ENSAPLP00000009810};
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anas.
OX   NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000009810, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000009810}
RP   NUCLEOTIDE SEQUENCE.
RA   Li N.;
RT   "The genome sequence and transcriptome of duck provide insight into
RT   the interaction host.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000009810}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23749191; DOI=10.1038/ng.2657;
RA   Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H.,
RA   Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q.,
RA   Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A.,
RA   Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J.,
RA   Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G.,
RA   Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M.,
RA   Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J.,
RA   Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J.,
RA   Li N.;
RT   "The duck genome and transcriptome provide insight into an avian
RT   influenza virus reservoir species.";
RL   Nat. Genet. 45:776-783(2013).
RN   [3] {ECO:0000313|Ensembl:ENSAPLP00000009810}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAPLP00000009810}.
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DR   EMBL; ADON01070231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01070232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01070233; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAPLT00000010509; ENSAPLP00000009810; ENSAPLG00000009789.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; WNIFDCI; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000016666; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016666};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    121    143       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    155    174       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    194    214       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    226    243       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    249    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    382    410       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    709    727       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    739    760       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    838    860       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    880    897       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    917    940       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1200   1218       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1239   1258       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1311   1337       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1432   1458       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1508   1531       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1551   1569       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1581   1600       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1636   1664       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1736   1759       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      124    416       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      472    658       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      709    944       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      954   1194       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1198   1467       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1516   1769       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1976 AA;  224659 MW;  5BF5151A16ECAE89 CRC64;
     MAEFILSDTN NFRKFTYESL AAIEKRIAAK KDRQKNAIDQ KPEEKPRPQL DLKAFQKLPA
     LYGSPPPELI GEPLEDLDPY YKDRKIFIVL NKQKTIFRFT ATRALWILSP FHPIRRTAIK
     ILIHSLFTWF IMCTILTNCV FMAQNESTSS SWNKYVEFTF TGIYTFESLI KILARGFCLN
     EFTFLRDPWN WLDFSVIVMA YVGAFSSLGS VSVLRTFRVL RALKTISVVP GLKIIVGALI
     QSVKKLTNVM ILTVFCLSVF ALIGLQLFKG NLRRKCMRNY TDSSIRESIE NQTWDSYETF
     DNYTVEHFAK KADSSDILVC GPGAGSRTCP PDYICLKIGP NPDYGFTSFD TFGWAFLSLF
     RLMTQDYWER LYQQTLRTSG KVYILFFMLV IFLGSFYLVN LILAVVTMAY EDQNKATIAE
     TEAKERKFRE AMELLQKEQE SLAAKGIDIL SISSFEASPL STKEIKERSN RKKRNKSLGV
     EDYEEQQFPK LQRTDSQRKL ALLGLVYGPN ANQVKRRLSH GSVFNFQIPS LEIDSKADFG
     DEETRSAGEN EIQGRSLSVP QVGRRCSLQS QASHGSHPAT PSSGQGGKWT NMDDCNGMIS
     VMGGGNGKVH GLDPASTEGV PLPPVMEDPG KGDLVSKSCC LEYFNEAFQR QRAASAVSII
     TSVLEELEES QRRCPPCLKD FALKYLIWDC CPLWLRIKKK VAAFIKDPFI DLTITLCIVM
     NTLFMALEHN NMSENFKSML NVGNLVFTGI FTAEMILKII ALDPYYYFQQ PWNIFDSIIV
     TLSLIELSLP KHRGKKERRK GGTLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSLGALS
     NLTLVLAIIV FIFAIVGVQL FGSNYRENKF KINKSGKPRW HMMDFFHSFL VIFRILCGEW
     IETMWDCMVV AEKPLCLLVF LLVMVIGNLV VLNLFIALLL NSFSTDCLQT AEDDGEMNNL
     RIAFARINKG FHLVKSVTWD TCCGKLRHLK KAHRKKNKLT AQNPLGLGKE RKNCKENYNN
     EWGEKNWEYC AGLEDFITNP NVFVCVPIAE AENTSDGFED DDKLSTFTDT EHSKQEENHL
     RQRGERGKNS GSWSKGSGLS SEEFSVLYLG KDRKAEPSSP EQKEIDSASS SEGSTVDLTN
     PEDLLRQIPE FAEDMKTPEK CFPEGCGRYF RCYKGSALNF GGQTWWNLRK TCYQIVEHSW
     FESFIIFMIL LSSGSLAFED IHIYKRKHIK DMLSFLDKMF TFIFVLEMLL KWVAYGFKKY
     FTNAWCWLDF FIVDVSLINL LGSSLDAVKS LRTLRALRPL RALSRFEGMR VVVNALIGAI
     PSIMNVLLVC LIFWLIFSIM GVNLFAGKFG KCVNMTEENS VLNASINDFT DCTTYNNTGK
     IFWVNVKVNF DNVGSGYLAL LQVATFKGWM DIMYAAVDSR EKNEQPKMEH SLFMYLYFVN
     FIIFGSFFTL NLFVGVIIDN FNQQKKKLGG EDIFMTEEQK KYYNAMKKLG SKKPQKPIPR
     PLNRYQGFLF DIVTRQAFDV VIMILICLNM ITMMVETYEQ SAMKTNILNK INILFVTIFT
     AECVVKLVAL RQYYFSNAWN IFDIVVVIMS LLALLLSGIG EALEHFLPPT LFRVIRLARI
     GRILRLIRAA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI YAIFGMANFA FVKMEDGIDD
     MFNFQTFANS MLCLFQITTS AGWDGLLSPI LNTGPPFCDP NVTGEVGECG KPAIGIIYFV
     SYIIISFLIV VNMYIAVILE NFNAATEEST EPLGEDDFDI FYEIWEKFDP EATQFITFSA
     LSDFADALAE PLRVPKPNKI ELIAMDLPMV SGDRIHCLDI LFAFTKRVLG DSGEMDALKV
     QMEEKFMSVN PSKKSYEPIS TTLRHRQEEA SATVIQRAYR SHLLQRSIKH ASYLYHHRTY
     SGDTLGDAAP EKEGLIASMM SENYGRNLEK SETSSSTSFP PSYDSVTRAS SGNLIV
//
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