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Database: UniProt
Entry: U3IU66_ANAPL
LinkDB: U3IU66_ANAPL
Original site: U3IU66_ANAPL 
ID   U3IU66_ANAPL            Unreviewed;      1992 AA.
AC   U3IU66;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   07-JUN-2017, entry version 30.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN8A {ECO:0000313|Ensembl:ENSAPLP00000010789};
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anas.
OX   NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000010789, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000010789}
RP   NUCLEOTIDE SEQUENCE.
RA   Li N.;
RT   "The genome sequence and transcriptome of duck provide insight into
RT   the interaction host.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000010789}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23749191; DOI=10.1038/ng.2657;
RA   Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H.,
RA   Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q.,
RA   Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A.,
RA   Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J.,
RA   Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G.,
RA   Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M.,
RA   Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J.,
RA   Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J.,
RA   Li N.;
RT   "The duck genome and transcriptome provide insight into an avian
RT   influenza virus reservoir species.";
RL   Nat. Genet. 45:776-783(2013).
RN   [3] {ECO:0000313|Ensembl:ENSAPLP00000010789}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAPLP00000010789}.
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DR   EMBL; ADON01096539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01096540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01096541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAPLT00000011507; ENSAPLP00000010789; ENSAPLG00000010964.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; YMIDEDH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000016666; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01667; NACHANNEL8.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016666};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    199    219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    254    274       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    387    414       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    766    784       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    796    814       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    876    904       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    963    989       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1211   1229       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1250   1269       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1281   1304       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1325   1353       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1450   1476       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1535   1553       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1565   1583       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1595   1615       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1652   1680       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1755   1778       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      131    421       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      498    709       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      766    993       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1003   1204       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1209   1484       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1534   1788       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      411    449       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1992 AA;  226641 MW;  9E225A50EB5D8EEC CRC64;
     MAARLLAPPG PDSFKPFTPE SLANIEKRIA EEKKKKRPKQ DSSHRDDDED SKPKPNSDLE
     AGKNLPFIYG DIPKGLVAVP LEDFDPYYMT QKTFVVLNRG KTLFRFSATP ALYILSPFNL
     FRRIAIKILI HSLFSMIIMC TILTNCVFMT FSNPPEWSKN VEYTFTGIYT FESLVKIIAR
     GFCIDGFTFL RDPWNWLDFS VIMMAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI
     VGALIQSVKK LSDVMILTVF CLSVFALIGL QLFMGNLRNK CVIWPINVNE TFLDNGSRGF
     DWEEYTNNMS NFYIIPGAPD PLLCGNSSDA GQCPEGYTCM KAGRNPNYGY TSFDTFSWAF
     LALFRLMTQD FWENLYQLTL RAAGKTYMIF FVLVIFVGSF YLVNLILAVV AMAYEEQNQA
     TLEEAEQKEA EFKAMLEQLK KQQEEAQAAA MVTSAGTVSE DAVEDDGGGR MSRSSSEISK
     VSSKSAKERR NRRKKRKDKE LSEGEEKGDA EKVFKSESED GMRRKAFRLP DNRIGRKFSI
     MNQSLLSIPG SPFLSRHNSK SSIFSYKGRF RDPGSENEFA DDEHSTVEES EGRRDSLFIP
     IRGRDRRSSY SGYSGYSQGS RSSRIFPNLR RNVKRNSTVD CNGVVSLIGG PPSSMPGGRL
     LPEVKIDKAA PDDSGTTEIE IKKKPGGSLL VSMDQVNVSY GRKDRTNSVM TGLTNTLVEV
     TVELEESQRK CPPCWYRFAN TFLIWECHPY WIKLKEIVNL IVMDPFVDLA ITICIVLNTL
     FMAMEHHPMT PEFEHVLSVG NLVFTGIFTA EMFLKLIAMD PYYYFQEGWN IFDGFIVSLS
     LMELGLANVE GLSVLRSFRL LRVFKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI
     FAVVGMQLFG KSYKECVCKI NPECELPRWH MHDFFHSFLI VFRVLCGEWI ETMWDCMEVA
     GQAMCLIVFM MVMVIGNLVV LNLFLALLLS SFSADNLAAT DDDGEMNNLQ ISVIRIKKGI
     AWIKAKVREF MHTHFKQRGG DEVKPLDELY DKKVNCIANH TGADINRDID YQKNGNGTTS
     GIGSSVEKYI IDEDHMSFIN NPNLTVRVPI AVGESDFENL NTEDFSSDTD PDGSKEKLDD
     TSSSEGSTID IKPEVEEVPV EAPEEYLDPD ACFTEGCMQR CKCCQVNIEE GLGKSWWTLR
     KTCFLIVEHN WFETFIIFMI LLSSGALAFE DIYIEQRKTI RTILEYADKV FTYIFILEML
     LKWCAYGFVK FFTNAWCWLD FLIVAVSLVS LVANALGYSE LGAIKSLRTL RALRPLRALS
     RFEGMRVVVN ALVGAIPSIM NVLLVCLIFW LIFSIMGVNL FAGKYHYCFN ETSEERFEID
     IVNNKTDCEA LMPPNSTEIR WKNVKINFDN VGAGYLALLQ VATFKGWMDI MYAAVDSRKQ
     EEQPKYEDNI YMYIYFVIFI IFGSFFTLNL FIGVIIDNFN QQKKKFGGQD IFMTEEQKKY
     YNAMKKLGSK KPQKPIPRPL NRIQGAVFDF VTQQAFDIVI MMLICLNMVT MMVETDTQSK
     QMEDILYWIN LVFVIFFTCE CVLKMFALRH YYFTIGWNIF DFVVVILSIV GMFLAEIIEK
     YFVSPTLFRV IRLARIGRIL RLIKGAKGIR TLLFALMMSL PALFNIGLLL FLVMFIFSIF
     GMSNFAYVKH EAGIDDMFNF ETFGNSMICL FQITTSAGWD GLLLPILNRP PDCDLDKEHP
     GSGFKGDCGN PSVGIFFFVS YIIISFLIVV NMYIAIILEN FSVATEESAD PLSEDDFETF
     YEIWEKFDPD ATQFIEYSKL ADFADALEHP LRVPKPNTIE LIAMDLPMVS GDRIHCLDIL
     FAFTKRVLGD SGELDILRQQ MEERFVASNP SKVSYEPITT TLRRKQEEVS AVVMQRAYRA
     RLARRGFVSR RPVPTKLENG GTNREKKEGT PSTASLPSYD SVTKPEKEKQ QRAEEGRREK
     AKRQKDVRES KC
//
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