GenomeNet

Database: UniProt
Entry: U3J0B1_ANAPL
LinkDB: U3J0B1_ANAPL
Original site: U3J0B1_ANAPL 
ID   U3J0B1_ANAPL            Unreviewed;       626 AA.
AC   U3J0B1;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   25-OCT-2017, entry version 21.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=TCIRG1 {ECO:0000313|Ensembl:ENSAPLP00000012938};
OS   Anas platyrhynchos (Mallard) (Anas boschas).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anas.
OX   NCBI_TaxID=8839 {ECO:0000313|Ensembl:ENSAPLP00000012938, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000012938}
RP   NUCLEOTIDE SEQUENCE.
RA   Li N.;
RT   "The genome sequence and transcriptome of duck provide insight into
RT   the interaction host.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000012938}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23749191; DOI=10.1038/ng.2657;
RA   Huang Y., Li Y., Burt D.W., Chen H., Zhang Y., Qian W., Kim H.,
RA   Gan S., Zhao Y., Li J., Yi K., Feng H., Zhu P., Li B., Liu Q.,
RA   Fairley S., Magor K.E., Du Z., Hu X., Goodman L., Tafer H., Vignal A.,
RA   Lee T., Kim K.W., Sheng Z., An Y., Searle S., Herrero J.,
RA   Groenen M.A., Crooijmans R.P., Faraut T., Cai Q., Webster R.G.,
RA   Aldridge J.R., Warren W.C., Bartschat S., Kehr S., Marz M.,
RA   Stadler P.F., Smith J., Kraus R.H., Zhao Y., Ren L., Fei J.,
RA   Morisson M., Kaiser P., Griffin D.K., Rao M., Pitel F., Wang J.,
RA   Li N.;
RT   "The duck genome and transcriptome provide insight into an avian
RT   influenza virus reservoir species.";
RL   Nat. Genet. 45:776-783(2013).
RN   [3] {ECO:0000313|Ensembl:ENSAPLP00000012938}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAPLP00000012938}.
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DR   EMBL; ADON01134684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01134685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01134686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01134687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01134688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01134689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01134690; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADON01134691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAPLT00000013685; ENSAPLP00000012938; ENSAPLG00000013129.
DR   GeneTree; ENSGT00390000004941; -.
DR   OMA; WRACRGF; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000016666; Unassembled WGS sequence.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0016236; P:macroautophagy; IEA:Ensembl.
DR   GO; GO:0007039; P:protein catabolic process in the vacuole; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 3.
DR   Pfam; PF01496; V_ATPase_I; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000016666};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    243    261       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    338    358       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    370    390       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    402    420       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    432    455       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   626 AA;  68637 MW;  FB7739EF39409327 CRC64;
     XLLWRACRGY LVASFVEMPE PLEDPDTGES VTWVIFLISY WGEQIGQKIR KISDCFHCQV
     YPYPESEASR AETLNGLLSQ IQDLSVVLEE SEQYLAQVLD KVVQALPTWR VQVQKMKAIY
     LVLNQCSLDV TEKCLIAEVW CPVRDLTQVQ DALRQGSVGA RCGGGCLGAP PRDCVVAPCP
     RGKACLVALC PCARNSLVAP CPHALGPHCL CARVTCPVLG RVMGRGQGAT FCPPQIWQMF
     FEGRYLILLM GAFSIYTGFI YNECFSKPTV IFPSAWSVAT MANRXAPSDY LATHPSLTLD
     PNITGVFQGP YPFGIDPIWS LATNHLNFLN SFKMKMSVVL GIVHMAFGVL LGVFNHALQA
     AAPHQLVLEL LPEVVFLLAL FGYLVFLIFY KWIKFGPADS RVAPSILIHF IDMFLFTSNA
     DNLPLYEGQV PVQMVLVVLA LASVPVLLLG TPLYLCCQRR RRKTGHPPPA AEQEPLLEGQ
     EAGNSVNATK EDVESGGHGP DSEHLDFSDV FMHQAIHTIE YCLGCISNTA SYLRLWALSL
     AHARXSEVLW SMVMRKGFVR LSYAGGAVLV PVLAAXGGGG GRTGPPTGPT GSHRAPSFLG
     RVEFQNKFYV GAGYKLCPFA FAPDSW
//
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