GenomeNet

Database: UniProt
Entry: U3JA71_DANRE
LinkDB: U3JA71_DANRE
Original site: U3JA71_DANRE 
ID   U3JA71_DANRE            Unreviewed;      1660 AA.
AC   U3JA71;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   25-OCT-2017, entry version 30.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
DE   Flags: Fragment;
GN   Name=cacna1g {ECO:0000313|Ensembl:ENSDARP00000127136,
GN   ECO:0000313|ZFIN:ZDB-GENE-090514-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000127136, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000127136, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127136,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000127136}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127136};
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000127136}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AL929109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX005134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01027640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01027641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01027642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT573007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7955.ENSDARP00000106730; -.
DR   PaxDb; U3JA71; -.
DR   Ensembl; ENSDART00000153256; ENSDARP00000127136; ENSDARG00000089913.
DR   ZFIN; ZDB-GENE-090514-2; cacna1g.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; FWRLICD; -.
DR   OrthoDB; EOG091G02L1; -.
DR   Proteomes; UP000000437; Chromosome 12.
DR   Bgee; ENSDARG00000089913; -.
DR   ExpressionAtlas; U3JA71; baseline.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    142    162       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    233    256       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    358    379       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    385    410       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    767    785       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    797    818       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    888    907       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    964    987       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1312   1330       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1350   1371       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1447   1469       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1548   1572       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1629   1647       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    421       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      766    993       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1310   1582       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1575   1602       {ECO:0000256|SAM:Coils}.
FT   NON_TER    1660   1660       {ECO:0000313|Ensembl:ENSDARP00000127136}.
SQ   SEQUENCE   1660 AA;  186558 MW;  8CE85B4745D29159 CRC64;
     MMAEDGGIIS EDNQLNEAEG SSSLPRTFIP LNDLSGGGVR SELESDGGER RESAAGGAAE
     ETSASDGEAL PYPSLAPVVF FYLKQTTRPR SWCLKMVCNP WFERASMLVI LLNCVTLGMF
     HPCEDSHCDS ERCKILEDFD DFIFAFFAVE MVIKMVALGI FGKKCYLGDT WNRLDFFIVL
     AGMLEYSLNL QNVSFSAVRT VRVLRPLRAI NRVPSMRILV TLLLDTLPML GNVLLLCFFV
     FFIFGIVGVQ LWAGLLRNRC FLPENFSLPT SLELRKYYHT ENDDENPFIC SQPRENGMRL
     CTSVPTLHEE GRQCQLDMAS YNSTDNTTCV NWNKYYTNCS AGEANPFKGA INFDNIGYAW
     IAIFQVITLE GWVDIMYFVM DAHSFYNFIY FILLIIVGSF FMINLCLVVI ATQFSETKQR
     ESQLMKEQRV RFRSNASTLN SYSEPGSCYD ELLKYLVHVI RKGTRQIAHL IRAAGRRAGL
     RICASPPLEA PPTKRRRQKQ RQGSIRHIMH HHHHHLHHHY HLGNGSVRSD GGREVDNPSQ
     SGIVNKSGNV NLMLPVIVPQ QDAFSGSFGH SSAESVHSVY QVSGHLEPLR CGPSPSPTVL
     HAYKRNSVPF AAPVHKNYPT LQSSLALEQL RQRILDPASV LTSLNIPPNP INTSQCLVET
     QGPPGKVISK DALMNCSSTN IDTALTYDPE TCPYCAKSMA NDSEGIDGNE TADSDSEGVY
     ETQVAHYRDS RGPKKKKKFA LGARATKVID FWRLVCGTFR KIVDSKYFGQ GIMIAILINT
     LSMGIEYHEQ PDELTNALEI SNIVFTSLFV LEMLLKLLVY GPFGYIKNPY NIFDGIIVVI
     SVWEIVGQQG GGLSVLRTFR LMRVLKLVRF MPALQRQLVV LMKTMDNVAT FCMLLMLFIF
     IFSILGMHLF GCKFGSERDG DTLPDRKNFD SLLWAIVTVF QILTQEDWNK VLYNGMASTS
     PVAALYFIAL MTFGNYVLFN LLVAILVEGF QTEEITKRDD LHGQLSCIQL PIDSGGDASK
     SDSEADIYAR SLEDVSGHKK DMSASSVVPI NGHVDLKSSL TPPLITHTAA TPMPIPKISG
     GGDSALSQES RRGSSVSMEP NGQDKSPSSA RSSPNAPLSS ASSWNSRRSS WNSLGRAPSL
     KRQKHQSGER RSLLSGDGQS SSDEGDAGES MGGMSEGDDA SLARTDSLGQ RPRHRRMESL
     ETRSSFDLHP DTLQVPYPHR SGSIHSARPP NFLSNGKTSP SAATTQLSLD EHHSEDDNAD
     EEGNLSRRAR LYRWLEHKQP EWCRQRVTWS LYLFPPESRF RVTCNKIITH KMFDHVVLVI
     IFLNCITIAM ERPRIDPSSA ERIFLTLSNY IFTAIFVTEM TIKVVALGFC FGEKTYLKSS
     WNILDGMLVM ISVIDILVSL ISNSGTKILG MLRVLRLLRT LRPLRVISRA PGLKLVVETL
     MSSLKPIGNI VVICCAFFII FGILGVQLFK GKFFVCHGDD TRNITNKSDC LLANYKWVRH
     KYNFDNLGQA LMSLFVLASK DGWVDIMYDG LDAVGVDQQP VMNYNPWMLL YFISFLLIVA
     FFVLNMFVGV VVENFHKCRR NQEEEEAKRR EAKRQKRRDK KRRKAQSKPF YSDYCPTRRL
     IYNMCKSQYL DLFITIVIAL NVITMSMEHY HQPKVLSDSL
//
DBGET integrated database retrieval system