ID U3JBV3_FICAL Unreviewed; 832 AA.
AC U3JBV3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN Name=LOC101821431 {ECO:0000313|Ensembl:ENSFALP00000000257.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000000257.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000000257.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000000257.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004451}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; U3JBV3; -.
DR STRING; 59894.ENSFALP00000000257; -.
DR Ensembl; ENSFALT00000000260.2; ENSFALP00000000257.2; ENSFALG00000000248.2.
DR eggNOG; KOG1023; Eukaryota.
DR GeneTree; ENSGT00940000163785; -.
DR HOGENOM; CLU_001072_9_0_1; -.
DR Proteomes; UP000016665; Chromosome Z.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF458; GUANYLATE CYCLASE; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Vision {ECO:0000256|ARBA:ARBA00023305}.
FT DOMAIN 286..553
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 618..748
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 804..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 92376 MW; 966CB3A4D8B8DDA1 CRC64;
MLVEGWHDLD NKDYDCWPLE KPDEYNMLDC GGLEMTWVQR PPEKAVSGES FNVTYSVFAS
DSFYQYAVQN GILSHSNVTA AKEFCEEHEC PVRWKDANGD NCCVYHANIH SCPLAFMAKG
GICGPWIPDD GQIFTHTLST AGKMSQRNWT AKVVLVHVGV TSLIAHIRVG RIQAALEAKT
TVLPAVVCGD GFCEEEEGCS ICPADCGECP LSLDVRIAIA LPICLVCTGF ILTVIWFQYQ
KQKMLWDESW IIDFTSIKQD CVIQTATGSM MSAPPAPSDS SVSCVTALSS CTAAANMSRR
KYFTQTGRYD GRTVAIKKIV KKAFTLSKTI RKEVKQVREL DHPNLCKFIG GCVEVPNVAI
VTEYCPKGSL SDVLLNEDIP LNWGFRFSFA TDIAQGMAYL HHHKMYHGRL KSNNCVIDDR
WVCKIADYGL QSYRKEDSSD GSSSSQQHLI YTAPEIHTLS DFEPNSMSDV YSYATILLEI
ATRSDPLAKD DVHSAEYSWC PSLAELISGK AGNSCPCPTD YIELIERCRR YNPSQRPTFE
QVKKMLYKMN PVSPVDMMMT LMEKYNKHLE ILVAERTQDL MHEKQKTDRL LYSMLPKQVA
DDLRQGKPAQ AQSYSSATIF FSDIVGFTEL SSSSTPYQVV DLLNKLYTTF DEIIDNYDVY
KVETIGDAYM VVSGVPKENG ILHAGEIASM ALDLLDVCKT FKIPHKPSTL LKIRAGIHSG
AVVAGVVGTK MPRYCLFGDT VNTASRMEST SEALKIQCSS SAYQLLEQIG EYVLVYRGNL
QVKGKGDMVT YWLEGKKASV TQQAVTSTPG TPQDANRLSY SPIPGVLPSG PL
//