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Database: UniProt
Entry: U3JBV3_FICAL
LinkDB: U3JBV3_FICAL
Original site: U3JBV3_FICAL 
ID   U3JBV3_FICAL            Unreviewed;       832 AA.
AC   U3JBV3;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 59.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN   Name=LOC101821431 {ECO:0000313|Ensembl:ENSFALP00000000257.2};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000000257.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000000257.2, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000000257.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU003431};
CC   -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC       {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004451}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   AlphaFoldDB; U3JBV3; -.
DR   STRING; 59894.ENSFALP00000000257; -.
DR   Ensembl; ENSFALT00000000260.2; ENSFALP00000000257.2; ENSFALG00000000248.2.
DR   eggNOG; KOG1023; Eukaryota.
DR   GeneTree; ENSGT00940000163785; -.
DR   HOGENOM; CLU_001072_9_0_1; -.
DR   Proteomes; UP000016665; Chromosome Z.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR011645; HNOB_dom_associated.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920:SF458; GUANYLATE CYCLASE; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07701; HNOBA; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Vision {ECO:0000256|ARBA:ARBA00023305}.
FT   DOMAIN          286..553
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          618..748
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          804..832
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        804..818
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   832 AA;  92376 MW;  966CB3A4D8B8DDA1 CRC64;
     MLVEGWHDLD NKDYDCWPLE KPDEYNMLDC GGLEMTWVQR PPEKAVSGES FNVTYSVFAS
     DSFYQYAVQN GILSHSNVTA AKEFCEEHEC PVRWKDANGD NCCVYHANIH SCPLAFMAKG
     GICGPWIPDD GQIFTHTLST AGKMSQRNWT AKVVLVHVGV TSLIAHIRVG RIQAALEAKT
     TVLPAVVCGD GFCEEEEGCS ICPADCGECP LSLDVRIAIA LPICLVCTGF ILTVIWFQYQ
     KQKMLWDESW IIDFTSIKQD CVIQTATGSM MSAPPAPSDS SVSCVTALSS CTAAANMSRR
     KYFTQTGRYD GRTVAIKKIV KKAFTLSKTI RKEVKQVREL DHPNLCKFIG GCVEVPNVAI
     VTEYCPKGSL SDVLLNEDIP LNWGFRFSFA TDIAQGMAYL HHHKMYHGRL KSNNCVIDDR
     WVCKIADYGL QSYRKEDSSD GSSSSQQHLI YTAPEIHTLS DFEPNSMSDV YSYATILLEI
     ATRSDPLAKD DVHSAEYSWC PSLAELISGK AGNSCPCPTD YIELIERCRR YNPSQRPTFE
     QVKKMLYKMN PVSPVDMMMT LMEKYNKHLE ILVAERTQDL MHEKQKTDRL LYSMLPKQVA
     DDLRQGKPAQ AQSYSSATIF FSDIVGFTEL SSSSTPYQVV DLLNKLYTTF DEIIDNYDVY
     KVETIGDAYM VVSGVPKENG ILHAGEIASM ALDLLDVCKT FKIPHKPSTL LKIRAGIHSG
     AVVAGVVGTK MPRYCLFGDT VNTASRMEST SEALKIQCSS SAYQLLEQIG EYVLVYRGNL
     QVKGKGDMVT YWLEGKKASV TQQAVTSTPG TPQDANRLSY SPIPGVLPSG PL
//
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