ID U3JCH7_FICAL Unreviewed; 403 AA.
AC U3JCH7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=Runt-related transcription factor {ECO:0000256|PIRNR:PIRNR009374};
GN Name=RUNX3 {ECO:0000313|Ensembl:ENSFALP00000000481.1};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000000481.1, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000000481.1, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000000481.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR009374}.
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DR RefSeq; XP_005058223.1; XM_005058166.1.
DR AlphaFoldDB; U3JCH7; -.
DR STRING; 59894.ENSFALP00000000481; -.
DR Ensembl; ENSFALT00000000484.2; ENSFALP00000000481.1; ENSFALG00000000470.2.
DR GeneID; 101821754; -.
DR KEGG; fab:101821754; -.
DR CTD; 864; -.
DR eggNOG; KOG3982; Eukaryota.
DR GeneTree; ENSGT00940000156598; -.
DR HOGENOM; CLU_032910_0_0_1; -.
DR OMA; TQGLWPE; -.
DR OrthoDB; 2881451at2759; -.
DR Proteomes; UP000016665; Chromosome 23.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0001222; F:transcription corepressor binding; IEA:Ensembl.
DR GO; GO:0051094; P:positive regulation of developmental process; IEA:UniProt.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR GO; GO:0071559; P:response to transforming growth factor beta; IEA:Ensembl.
DR Gene3D; 2.60.40.720; -; 1.
DR InterPro; IPR000040; AML1_Runt.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
DR InterPro; IPR013524; Runt_dom.
DR InterPro; IPR027384; Runx_central_dom_sf.
DR InterPro; IPR013711; RunxI_C_dom.
DR InterPro; IPR016554; TF_Runt-rel_RUNX.
DR PANTHER; PTHR11950; RUNT RELATED; 1.
DR PANTHER; PTHR11950:SF43; RUNT-RELATED TRANSCRIPTION FACTOR 3; 1.
DR Pfam; PF00853; Runt; 1.
DR Pfam; PF08504; RunxI; 1.
DR PIRSF; PIRSF009374; TF_Runt-rel_RUNX; 2.
DR PRINTS; PR00967; ONCOGENEAML1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS51062; RUNT; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR009374};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR009374};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR009374}.
FT DOMAIN 47..175
FT /note="Runt"
FT /evidence="ECO:0000259|PROSITE:PS51062"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 109
FT /ligand="chloride"
FT /ligand_id="ChEBI:CHEBI:17996"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
FT BINDING 113
FT /ligand="chloride"
FT /ligand_id="ChEBI:CHEBI:17996"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
FT BINDING 136
FT /ligand="chloride"
FT /ligand_id="ChEBI:CHEBI:17996"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
FT BINDING 167
FT /ligand="chloride"
FT /ligand_id="ChEBI:CHEBI:17996"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR009374-1"
SQ SEQUENCE 403 AA; 43401 MW; B70383B58DB12D26 CRC64;
MRIPVDPSTS RRFTPPSTAF PCGKMGENSG ALGAPAPGAR ARPEVRSVVD VLADHAGELV
RTDSPNFLCS VLPSHWRCNK TLPVAFKVVA LGDVPDGTVV TVMAGNDENY SAELRNASAV
MKNQVARFND LRFVGRSGRG KSFTLTITVF TNPTQVATYH RAIKVTVDGP REPRRHRQKL
EDQAKPFTDR YGDLERLRQS MRVTPTTPNP RGSLSTPGHF GSQAQTPIQG TSELSPFSDP
RQFERSFPAL PALTETRFSD PRMHYPGAMS AAFPYTATPS ATGIGGISMS GMPTATRFHH
TYLPPPYPSS TQNQSGPFQA NPSPYHLYYG TSSGSYQFSM VAGGERSPTR MLSSCSSASA
GNSLMNAGLG AQSDGVDADG SHSNSPTAMS TTGRMDESVW RPY
//
