ID U3JKD2_FICAL Unreviewed; 411 AA.
AC U3JKD2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Even-skipped homeobox 2 {ECO:0000313|Ensembl:ENSFALP00000003236.2};
GN Name=EVX2 {ECO:0000313|Ensembl:ENSFALP00000003236.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000003236.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000003236.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000003236.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the even-skipped homeobox family.
CC {ECO:0000256|ARBA:ARBA00038449}.
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DR AlphaFoldDB; U3JKD2; -.
DR STRING; 59894.ENSFALP00000003236; -.
DR Ensembl; ENSFALT00000003249.2; ENSFALP00000003236.2; ENSFALG00000003109.2.
DR eggNOG; KOG0844; Eukaryota.
DR GeneTree; ENSGT00940000161025; -.
DR HOGENOM; CLU_045075_1_0_1; -.
DR Proteomes; UP000016665; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0035108; P:limb morphogenesis; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR46294:SF1; HOMEOBOX EVEN-SKIPPED HOMOLOG PROTEIN 2; 1.
DR PANTHER; PTHR46294; SEGMENTATION PROTEIN EVEN-SKIPPED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 210..270
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 212..271
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 345..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 411 AA; 38662 MW; 910B478969BBCB93 CRC64;
MMERIRKEMI LMERGLHSPT AGKRLSNLSD SAGNAVLEAL ENSPHSGRLS PRLTAASLHS
AIGDISAKGK FEIDTLFNLQ HPSSESTVSS EIPPSESRKK ISLYSEVAQE ADMNSDVEVG
CSAAPAAAAA PGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG
GGGGGGGGGG GGGGGGGGGG GGGGGGAGAD QVRRYRTAFT REQIARLEKE FYRENYVSRP
RRCELAAALN LPETTIKVWF QNRRMKDKRQ RLAMSWPHPA DPSFYTYMMT HAAATGTAAA
PFATSIRPLD TFRALSHPYS RPELLCSFRH PGLYQTPPCP VCPTLSTPTS RCTTTRTSGS
GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG GGGGGGGGGG G
//
