ID U3JKI2_FICAL Unreviewed; 418 AA.
AC U3JKI2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 60.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000003286.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000003286.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000003286.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR AlphaFoldDB; U3JKI2; -.
DR STRING; 59894.ENSFALP00000003286; -.
DR Ensembl; ENSFALT00000003299.2; ENSFALP00000003286.2; ENSFALG00000003135.2.
DR eggNOG; KOG1339; Eukaryota.
DR GeneTree; ENSGT00940000163644; -.
DR HOGENOM; CLU_013253_3_0_1; -.
DR Proteomes; UP000016665; Chromosome 26.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1960; -; 1.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF70; PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 103..415
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 121
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 307
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 134..139
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 418 AA; 46060 MW; D522705CFE432F67 CRC64;
MESSSWDMES SSWDRRAAGH GAQRTEPLKM PNYSYSPLCA VVFCLSLCRI SLKKGLSIRD
KMRTAGVLDD FLKHIKYDPV KKYQPSQGSV VRQPITNHLD SSYFGEISIG EPPQKFLVLF
DTGSSNLWVP SMDCKSPACF NHAKFQPNDS VTFSPSDRSH TVSYGSGSVT IALGYDTLRI
QSITVTNQEF GLSQDEPTQP FYFADFDGIL GMAYPSLAVG GMATALEGML EQDQLAEPIF
SFYFSRQPTY EYGGELILGG IDPRLFQGDI TWAPVAQKLY WQVALEEFAI GQSVTSWCSQ
GCQAIVDTGT FLLTVPQEYI ESILQAVGAQ ETSYGFAVDC NDTQSLPPIT FGIGGAQLPL
SPSTYVLNSN GYCTLGIEVT YLPSEDGQPL WILGDVFLKE YYTIFDMANN RVGFALSV
//
