ID U3JN95_FICAL Unreviewed; 573 AA.
AC U3JN95;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
GN Name=NPRL3 {ECO:0000313|Ensembl:ENSFALP00000004249.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000004249.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000004249.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000004249.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC {ECO:0000256|RuleBase:RU368069}.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC ECO:0000256|RuleBase:RU368069}.
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DR AlphaFoldDB; U3JN95; -.
DR STRING; 59894.ENSFALP00000004249; -.
DR Ensembl; ENSFALT00000004270.2; ENSFALP00000004249.2; ENSFALG00000004078.2.
DR eggNOG; KOG3830; Eukaryota.
DR GeneTree; ENSGT00390000015916; -.
DR HOGENOM; CLU_014030_1_0_1; -.
DR Proteomes; UP000016665; Chromosome 14.
DR GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR InterPro; IPR005365; Npr3.
DR PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR Pfam; PF03666; NPR3; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|RuleBase:RU368069};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Signal {ECO:0000256|RuleBase:RU368069}.
FT REGION 32..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 63422 MW; D85DEA6051BF0017 CRC64;
MGESTSPISV ILVSSGSRGN KLLFRFPFQR GAEHPAAQDN KPRSRYAVNG SGDTTEDQDG
DSRDQCPLTD EQLVSGFSDV ILATILATKS DMCGKKFELK IDNVRFVGHP TLLQHALGQV
SKTDPSPKRE MPTMILFNVV FALRANADPS VISCLHNLSR RIAIVLQHEE RRCQYLTREA
KLILAIQDEV SAMAETTEGP QSPFHHILPK CKLARDLKET YDSLCTTGVV RLHINNWLEV
SFCLPHKIHY VATNFIPPEA IERSLKSIRP YHALLLLNDE KSLLNELPLD CSPALVRVIK
TTSAVKNLQQ LAQDADLALL QVFQLAAHLV YWGKAIIIYP LCENNVYMLS PNASVCLYSP
LADAFSCQFR GHNLPSMLAK FSLPVSLSEF KNPLAPPVQE TQLIQMVIWM LQHRLLIQLH
TYVCLMVPPN EEELRAQEED VPFTARVGGR SLSTPNALSF GSPTSSDDMT LTSPSMDNSS
AELIPGGDSP LNKRMTENLL ASLLEHEREA ILNVPAAQNP EDLRMFASER TMVELPEGAD
LPHCPPAGCC TTSEAGTTWR RSCTTRTCGA RSC
//
